Navigation Links
Abnormal DNA maintenance related to cancer
Date:12/10/2012

DNA, like houses and cars, needs ongoing maintenance. Rays of ultraviolet sunlight, chemical pollutants and normal biochemical processes in the cell can damage it. Cells routinely repair this damage before making proteins or copying DNA for cell division. The repairs are remarkably accurate in normal cells but cancer cells make far more mistakes in fixing their DNA. Alan Tomkinson, PhD, University of New Mexico Professor of Internal Medicine and Associate Director of Basic Research at the UNM Cancer Center, wants to understand why and how these repair mechanisms go awry in cancer cells. This understanding could lead to new targets for cancer drugs. Dr. Tomkinson recently won a 4-year $1 million grant renewal to continue his 18-year research investigation on DNA ligases, the enzymes that repair DNA strands.

DNA ligases fuse the backbone of a DNA strand. The strand is a long string of nucleotides that structurally resembles one half of a ladder sliced lengthwise through the rungs. Each nucleotide consists of a deoxyribose molecule with a phosphate molecule on one side and a base molecule on another. The phosphate of one nucleotide attaches to the deoxyribose of the adjacent nucleotide, forming the alternating phosphate-deoxyribose DNA strand backbonethe side of the ladder. In a DNA moleculea full laddereach base attaches to a complementary base on the mirror strand to form the rung-like structures that encode genes.

Products of normal cellular chemical reactions and DNA repair proteins that replace damaged bases can break the phosphate-deoxyribose backbone. If only one strand is broken, the overall DNA structure remains intact because the bases of the broken strand still attach to those of the second, unbroken strand. It is relatively simple for DNA ligases to fuse such single-strand breaks. The DNA molecule falls apart, however, if both strands are broken at the same time and in the same place. In this situation, the cell has several differen
'/>"/>

Contact: Michele Sequeira
MSequeira@salud.unm.edu
505-925-0486
University of New Mexico Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Documenting womens experiences with chromosome abnormalities found in new prenatal test
2. Abnormal carotid arteries found in children with kidney disease
3. Double drug combo could shut down abnormal blood vessel growth that feeds disease
4. Brain Scans of Hoarders Show Unique Abnormalities
5. Gene Mutation Linked to Facial, Skull Abnormalities
6. Myelodysplastic Syndrome Linked to Abnormal Stem Cells
7. Genome-wide analysis shows previously undetected abnormalities in parents of affected children
8. Abnormal gene product associated with prostate cancer generated by unusual mechanism
9. Treatment of childhood OSA reverses brain abnormalities
10. Genetic abnormalities in benign or malignant tissues predict relapse of prostate cancer
11. Insecticide Linked to Brain Abnormalities in Kids
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/27/2014)... New York (PRWEB) November 27, 2014 ... ) have been filed in a consolidated litigation ... LLP reports. , Documents recently updated in ... records included in the state proceeding, all of ... bipolar disorder and other psychiatric conditions. Many of ...
(Date:11/27/2014)... Nov. 26, 2014 (HealthDay News) -- Most babies and ... cold, the U.S. Food and Drug Administration says. ... given to children younger than 2 because they could ... warned. American adults average about three colds a ... get a cold, parents might want to give them ...
(Date:11/27/2014)... Thanksgiving meals can pose a challenge for people who ... Many traditional Thanksgiving dishes -- such as turkey, ... but "when it comes to pies, stuffing, gravy, etc., ... Safta, director of the Gluten and Allergic Digestive Disorders ... Carolina, said in a center news release. "For ...
(Date:11/27/2014)... The founders of VIM & VIGR, a ... functioning compression socks, are proud to announce the debut of ... Gradient Pressure (TM) knitting technology that is designed to increase ... commitment to adding flair and style to a product that ... the eye of a writer at The New York ...
(Date:11/27/2014)... 2014 Now that Thanksgiving is finally ... launched, Emassagechair.com has announced its eagerly awaited, ... , Negotiating on behalf of their customers, and ... brands, Emassagechair.com has generated significant buzz in the industry ... discounts yet. , Shoppers are excited for significant savings ...
Breaking Medicine News(10 mins):Health News:New Risperdal Lawsuits Added to Philadelphia Litigation, Bernstein Liebhard LLP Reports 2Health News:New Risperdal Lawsuits Added to Philadelphia Litigation, Bernstein Liebhard LLP Reports 3Health News:New Risperdal Lawsuits Added to Philadelphia Litigation, Bernstein Liebhard LLP Reports 4Health News:Steer Clear of Cold Meds for Babies, FDA Advises 2Health News:Expert Shares Gluten-Free Thanksgiving Tips 2Health News:VIM & VIGR Announces Launch of Men’s Line of Compression Socks 2Health News:Emassagechair.com is Excited to Announce Their Biggest Discount Event of the Year, Starting the Day After Thanksgiving and Lasting Through The Holiday Weekend. 2Health News:Emassagechair.com is Excited to Announce Their Biggest Discount Event of the Year, Starting the Day After Thanksgiving and Lasting Through The Holiday Weekend. 3Health News:Emassagechair.com is Excited to Announce Their Biggest Discount Event of the Year, Starting the Day After Thanksgiving and Lasting Through The Holiday Weekend. 4
... N.C., July 29 DiaLog, Inc., a ... joint agreement with DeliverMed,Holdings, LLC, an Illinois-based, ... the DiaLog System, promotes compliance,and adherence to ... and their,physicians better manage their disease. DeliverMed ...
... of people world-wide who have contracted a highly resistant ... new drug to treat the infection. , Research ... National Centre in HIV Epidemiology and Clinical Research (NCHECR) ... responded to traditional treatments have had good results from ...
... researchers note risk dissipates quickly once smoking spouse quits , , ... to smokers run a significantly higher risk for experiencing a ... ex-smokers married to men and women who still smoke carry ... former smokers do not appear to bear any higher risk ...
... ASHEVILLE, N.C., July 29 DoctorDirectory.com, ... DAVA Pharmaceuticals, Inc. to,co-market VoSpire ER(R) ... virtual marketing solution. IncreaseRx utilizes,web-based educational ... of thousands of,interested prescribers with targeted ...
... The,Hospitalist Company, Inc. (Nasdaq: IPCM ), a leading ... will report,results for its second quarter 2008 ended June ... close., A conference call to review the results ... August 12, 2008 and will be hosted by Adam ...
... of Patients in National Survey Showed Reduction in Fall ... Strides,the pioneering home balance therapy program from Gentiva Health ... pain and,increasing sensation for thousands of older Americans, according ... released today by the Company., The year-long survey ...
Cached Medicine News:Health News:DiaLog Signs Agreement with DeliverMed to Improve Diabetic Patient Management 2Health News:New therapy for HIV treatment 2Health News:Secondhand Smoke Raises Stroke Risk for Spouses 2Health News:Secondhand Smoke Raises Stroke Risk for Spouses 3Health News:DoctorDirectory to Co-market VoSpire ER(R) with DAVA Pharmaceuticals, Inc. 2Health News:IPC The Hospitalist Company, Inc. to Report Second Quarter 2008 Financial Results 2Health News:Gentiva Safe Strides(R) Home Balance Therapy Program is Reducing Risk of Dangerous Falls and Relieving Pain for Thousands of Older Americans 2Health News:Gentiva Safe Strides(R) Home Balance Therapy Program is Reducing Risk of Dangerous Falls and Relieving Pain for Thousands of Older Americans 3Health News:Gentiva Safe Strides(R) Home Balance Therapy Program is Reducing Risk of Dangerous Falls and Relieving Pain for Thousands of Older Americans 4Health News:Gentiva Safe Strides(R) Home Balance Therapy Program is Reducing Risk of Dangerous Falls and Relieving Pain for Thousands of Older Americans 5
(Date:11/26/2014)... -- According to the new research ... Battery, Pneumatic), by Product (Drill, Saw, Stapler, Reamer, ... (Orthopedic, ENT, Oral, Thoracic, Neurology) - Global Forecasts ... Instruments Market is estimated to be worth around ... expected to grow at a moderate CAGR during ...
(Date:11/26/2014)... , Nov. 25, 2014  Medtronic,s ... has been widely discussed in the media ... also creating a stronger leading player in one ... Kalorama Information.  The healthcare market research firm said ... will feature a diverse set of solutions spanning ...
(Date:11/26/2014)... , Nov. 25, 2014  Array BioPharma ... announced that its Chief Executive Officer, ... following upcoming conferences.  The public is welcome ... on the Array BioPharma website:  www.arraybiopharma.com ... 2014Time:1:30 p.m.  Eastern Time Location: Palace Hotel, ...
Breaking Medicine Technology:Powered Surgical Instruments Market Worth $2.1 Billion by 2019 2Powered Surgical Instruments Market Worth $2.1 Billion by 2019 3Powered Surgical Instruments Market Worth $2.1 Billion by 2019 4Medtronic - Covidien: Beyond Taxes, Deal Will Create Patient Monitoring Power, according to Kalorama Information 2Medtronic - Covidien: Beyond Taxes, Deal Will Create Patient Monitoring Power, according to Kalorama Information 3
... 2011 UCB, a leading biopharmaceutical company at the forefront ... College of Gastroenterology (ACG) meeting in Washington, D.C. by reinforcing ... disease. At this year,s ACG meeting, a large body of ... in treatment of moderate to severe Crohn,s disease. ...
... Natrix Separations, Inc. announced today new members of its leadership ... Officer and Molly S. McGlaughlin as Vice President of Business ... of Directors since mid-2010, and will continue to hold a ... C. Howie Honeyman, Ph.D. will continue as Senior Vice ...
Cached Medicine Technology:UCB Proudly Reinforces Long-Standing Commitment to Patients and Physicians at American College of Gastroenterology 2011 Annual Scientific Meeting 2UCB Proudly Reinforces Long-Standing Commitment to Patients and Physicians at American College of Gastroenterology 2011 Annual Scientific Meeting 3Natrix Separations Introduces New Leadership Team 2Natrix Separations Introduces New Leadership Team 3
Modular hip abduction system designed to provide superior fit, adjustability and functionality for optimum patient stability, comfort and compliance...
... Harness™ A Pavlik-type harness with greatly ... treatment of congenital hip dysplasia. Color-coded ... and antislip foot pieces.,Color-coded anterior straps ... can be made while the child ...
... in walker design in years. A real step forward! ... surfaces of the foot rest on adaptive areas of ... strike. The footbed in the sole conforms to the ... stability. , ,No leg length discrepancy; Heel height ...
... This low cost walker features a ... innersole. The low profile design minimizes leg ... with D-rings makes strapping quick and easy. ... to accomodate swollen ankles and extra bandaging. ...
Medicine Products: