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Abilify Has Made Strong Gains in Patient Share Across All Lines of Therapy Since Last Year's Analysis of Prescribing Trends in Schizophrenia
Date:7/23/2009

WALTHAM, Mass., July 23 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms focusing on pharmaceutical and healthcare issues, finds that the patient share of Bristol-Myers Squibb/Otsuka's Abilify has grown in the first three lines of therapy since the 2008 analysis of prescribing trends in newly diagnosed schizophrenia patients. Abilify is second to risperidone (Janssen's Risperdal, generics) in first and second lines of therapy and leads other atypicals in the third line.

"Abilify's first-line patient share grew from 4.2 percent in our 2008 analysis to 14.6 percent in the current dataset. Pfizer's Geodon also grew substantially compared with our 2008 analysis whereas both Eli Lilly's Zyprexa and AstraZeneca's Seroquel lost first-line patient share," stated Nicole Westphal, Ph.D., analyst at Decision Resources. "These data suggest that Abilify and Geodon's better penetration of first-line therapy came at the expense of others in the class and we attribute Zyprexa's and Seroquel's declining use across early lines of therapy to concerns about their metabolic side effects."

The new Treatment Algorithms in Schizophrenia report also finds that surveyed psychiatrists will remain focused on an agent's metabolic or weight gain side effects when treating current and newly diagnosed patients. The majority of surveyed psychiatrists will switch patients from atypicals with unfavorable metabolic side-effect profiles to those with more favorable profiles or increasingly consider weight gain and metabolic side-effect profiles when choosing an antipsychotic in the first-line.

By combining patient-level claims data with physician survey data, this report can be used to build patient-flow models and analyze the assumptions driving these models.

Patient-flow analysis for Janssen's Invega shows that only three perce
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SOURCE Decision Resources
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