Navigation Links
Abbreviated Trials Yield Misleading Results: Study
Date:3/23/2010

Researchers must resist pressure for early halt, expert says

TUESDAY, March 23 (HealthDay News) -- Many positive treatment effects are exaggerated in clinical trials that are stopped early due to encouraging results, a new study has found.

In a comparison of 91 truncated trials with 424 comparable full-length trials, researchers found that the trials that ended early -- in particular, smaller studies -- reported exaggerated or misleading treatment effects.

"Our research shows that in most cases, early stopping of clinical trials resulted in misleading estimates of treatment effects. These misleading estimates are likely to result in misguided decisions about the trade-off between risks and benefits of a therapy," study corresponding author Dr. Victor Montori, a Mayo Clinic endocrinologist, said in a news release.

"On average, treatments with no effect would show a reduction in relative risk of almost 30 percent in stopped early trials. Treatments with a true relative risk reduction of 20 percent would show a reduction of over 40 percent," Montori said.

Almost everyone -- doctors, researchers, funding sources, drug makers, medical journals -- benefits from a clinical trial ending early, Montori noted. But patients don't benefit because they may end up receiving a therapy on the basis of misleading information about its benefits.

Montori and colleagues said that researchers must resist pressure to end clinical trials early and continue trials until they're nearly completed before even considering an early halt.

The study was published March 23 in the Journal of the American Medical Association.

More information

The U.S. National Institutes of Health has more about clinical trials.



-- Robert Preidt


<
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. FDA Issues Guidance to Help Streamline Medical Device Clinical Trials
2. European Cancer Organization supports a revision of the EU Clinical Trials Directive
3. Human guinea pigs wary of high-paying medical trials
4. Clinical trials launched for treating most aggressive brain tumor with personalized cell vaccines
5. ePRO on Netbooks (NetPRO) - The BEST ePRO Solution for Clinical Trials in 15 Years
6. Almac Launches New STEMS System to Transform Temperature Controlled Shipment Monitoring in Clinical Trials
7. Mesothelioma Clinical Trials List Offered by IQ Mesothelioma: Search Current Mesothelioma Treatment Options
8. State payer mandates to cover cancer trials offer heterogeneous protection for patients
9. LSUHSC research yields promising stroke treatment
10. Compulsive Dogs Yield Clues to Human OCD, Autism
11. Battlefield camaraderie yields long-term dividends for veterans, study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... Scientists have identified the first genetic variant specifically ... sub-type accounting for around 10-15 per cent of ... study of the breast cancer sub-type, called invasive ... genetic causes of this particular kind of breast ... The research, published today (Thursday) in the journal ...
(Date:4/17/2014)... in PLOS Pathogens , children who live in ... mount an immune response to infection with malaria parasites ... high fever and illness and partially control the growth ... help researchers develop future interventions that prevent or mitigate ... year, approximately 200 million cases of malaria occur worldwide, ...
(Date:4/17/2014)... Colo. (April 17, 2014) Two recent papers ... researcher and colleagues may help scientists develop treatments ... Yellow fever, Japanese encephalitis and other disease-causing flaviviruses. ... biochemistry and molecular genetics at the School of ... Howard Hughes Medical Institute, and colleagues recently published ...
(Date:4/17/2014)... A Northwestern University synthetic biology team has created ... create programmable therapeutics that could travel the body ... disease. , Engineering cell-based, biological devices that monitor ... in clinical synthetic biology. However, no existing technology ... a patient,s physiological state and respond in a ...
(Date:4/17/2014)... that as many as 10 million older Americans suffer ... and isolation. , However, new research a project ... Americans for six years found that Internet use ... by more than 30 percent. , "That,s a very ... professor of telecommunication, information studies and media who led ...
Breaking Medicine News(10 mins):Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 3Health News:Study sheds light on how the immune system protects children from malaria 2Health News:CU researchers discover target for treating dengue fever 2Health News:Building 'smart' cell-based therapies 2Health News:Internet use can help ward off depression among elderly 2
... ... Awards Ceremony Reminded Everyone of the Importance of One Simple Thing: Good Posture. ... (PRWEB) March 11, ... poor posture of some presenters than on the Vera Wang dresses or breakout performances ...
... ... of $25 or more for all hand and body lotions as well as facial serums. ... Southfield, Mich. (PRWEB) March ... lotions with an emphasis on the key ingredient African Shea butter. The products are highly ...
... ... few weeks, thousands of college students across the U.S. will travel abroad ... abusive drinking. Kathleen Quartaro, a Choose Responsibility volunteer and mother of a ... drinking during her freshman year, urges parents and students to discuss the ...
... ... put an end to decades of unethical and disinterested leadership in Northern Manhattan by supporting ... ... 2010 -- After decades of serving the men and women of New York City through ...
... ... Houston and will soon be expanding nationwide. Local IT Companies connects businesses with up to ... , ... It seems most business owners are entrenched in their own day to day business building ...
... ... company that takes pride in providing accurate information on sexuality and toys for grown-ups, ... , ... March 11, 2010 -- Good Vibrations , the legendary San Francisco-based company that takes ...
Cached Medicine News:Health News:Slouching Stars at the Oscars: Could the PostureNOW Posture Brace Have Helped Miley? 2Health News:Free Shipping On Hand and Body Lotions Made with African Shea Butter 2Health News:Mother of Binge Drinking Victim Urges Students and Parents to Discuss Signs of Alcohol Poisoning, Emphasize Peer Responsibility Prior to Spring Break 2Health News:Rev. Michel Faulkner Seeks to Retire Charlie Rangel from New York's 15th Congressional Seat 2Health News:Rev. Michel Faulkner Seeks to Retire Charlie Rangel from New York's 15th Congressional Seat 3Health News:LocalITCompanies.com now Helping Chicago, Dallas and Houston Businesses Find Pre-Screened IT Companies 2Health News:LocalITCompanies.com now Helping Chicago, Dallas and Houston Businesses Find Pre-Screened IT Companies 3Health News:Good Vibrations' Pleasure-Ed Series Brings High Quality Erotic Education to the Classroom and the Bedroom 2
(Date:1/15/2014)... , Jan. 15, 2014  Zafgen, Inc., a ... needs of severely obese patients, today announced initial ... a selective inhibitor of methionine aminopeptidase 2 (MetAP2), ... form of genetic obesity.  These results showed improvements ...
(Date:1/14/2014)... InformEx, North America,s leading business partnering ... the 30 th edition of its annual conference at ... January 21-24. (Logo: http://photos.prnewswire.com/prnh/20131028/NY05330LOGO-a ) ... and specialty chemical companies will take part in the conference, ...
(Date:1/14/2014)... 2014 Animal Emergency Critical Care, a LifeCentre partner practice, located ... is the first in Loudoun County ... Dr. Susan M. Barnes , Medical Director, is a well-seasoned ... Cole Taylor , are avid scuba divers. "As altitude skiers ...
Breaking Medicine Technology:Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 2Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 3Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 4Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2
... OncoSec Medical Incorporated (OTCBB: ONCS), which is ... solid tumor cancers, announced today clinical study results ... Future of Ablation Therapies conference in Las Vegas, ... titled, "OMS ElectroChemotherapy: Targeted Ablation of Solid Tumors ...
... Nonin Medical, Inc., the inventor of finger pulse ... announced the launch of the Onyx® Vantage 9590 professional ... 2011 Annual Congress in The Netherlands. The Onyx® Vantage ... the presence of low perfusion. The new device features ...
Cached Medicine Technology:Update: OncoSec Announces Positive Results From Head & Neck and Breast Cancer Trials 2Update: OncoSec Announces Positive Results From Head & Neck and Breast Cancer Trials 3Update: OncoSec Announces Positive Results From Head & Neck and Breast Cancer Trials 4Nonin Medical Launches Onyx® Vantage 9590 Professional Finger Pulse Oximeter at ERS Annual Congress 2
... Healthcare is known as ... analysis programs for every ... device. With advanced programs ... and ACI-TIPI, GE can ...
For use in vitreo-retinal procedures with a non contact system, and compatible with the Oculus BIOM system, this lens delivers the highest image clarity available in a non contact surgical lens....
... Affinity pacemaker family offers ... truly automatic devices. Featuring ... of advanced technologies ever ... pacemaker incorporates the exclusive ...
... family features St. Jude Medical's ... lead is available in both ... silicone (IsoFlex S lead) models, ... and multiple lead lengths, providing ...
Medicine Products: