Navigation Links
Abbreviated Trials Yield Misleading Results: Study
Date:3/23/2010

Researchers must resist pressure for early halt, expert says

TUESDAY, March 23 (HealthDay News) -- Many positive treatment effects are exaggerated in clinical trials that are stopped early due to encouraging results, a new study has found.

In a comparison of 91 truncated trials with 424 comparable full-length trials, researchers found that the trials that ended early -- in particular, smaller studies -- reported exaggerated or misleading treatment effects.

"Our research shows that in most cases, early stopping of clinical trials resulted in misleading estimates of treatment effects. These misleading estimates are likely to result in misguided decisions about the trade-off between risks and benefits of a therapy," study corresponding author Dr. Victor Montori, a Mayo Clinic endocrinologist, said in a news release.

"On average, treatments with no effect would show a reduction in relative risk of almost 30 percent in stopped early trials. Treatments with a true relative risk reduction of 20 percent would show a reduction of over 40 percent," Montori said.

Almost everyone -- doctors, researchers, funding sources, drug makers, medical journals -- benefits from a clinical trial ending early, Montori noted. But patients don't benefit because they may end up receiving a therapy on the basis of misleading information about its benefits.

Montori and colleagues said that researchers must resist pressure to end clinical trials early and continue trials until they're nearly completed before even considering an early halt.

The study was published March 23 in the Journal of the American Medical Association.

More information

The U.S. National Institutes of Health has more about clinical trials.



-- Robert Preidt



SOURCE: Mayo Clinic, news release, March 23, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. FDA Issues Guidance to Help Streamline Medical Device Clinical Trials
2. European Cancer Organization supports a revision of the EU Clinical Trials Directive
3. Human guinea pigs wary of high-paying medical trials
4. Clinical trials launched for treating most aggressive brain tumor with personalized cell vaccines
5. ePRO on Netbooks (NetPRO) - The BEST ePRO Solution for Clinical Trials in 15 Years
6. Almac Launches New STEMS System to Transform Temperature Controlled Shipment Monitoring in Clinical Trials
7. Mesothelioma Clinical Trials List Offered by IQ Mesothelioma: Search Current Mesothelioma Treatment Options
8. State payer mandates to cover cancer trials offer heterogeneous protection for patients
9. LSUHSC research yields promising stroke treatment
10. Compulsive Dogs Yield Clues to Human OCD, Autism
11. Battlefield camaraderie yields long-term dividends for veterans, study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/17/2017)... ... August 17, 2017 , ... Dr. Charles ... Through Forgiveness ($15.99, paperback, 9781498497626; $7.99, eBook, 9781498497633) focuses on the treatment ... of memories and achieve forgiveness, through a progressive journey toward healing. This book ...
(Date:8/17/2017)... , ... August 17, 2017 , ... Momkus McCluskey ... newest Partner. Ms. Parks is a member of the firm’s Commercial Litigation and Employment ... and provides a wealth of knowledge in matters of employment litigation, commercial litigation and ...
(Date:8/17/2017)... ... , ... A recent report indicates that circa 79 percent of 483 warning ... data integrity. The FDA outlines their expectations for quality critical instrumentation in the GMP ... the Beckman Coulter Life Sciences Virtual Trade Show Virtual Event, this webinar ...
(Date:8/16/2017)... ... August 16, 2017 , ... Blue Health Intelligence (BHI) ... President, Chief Medical Officer. Dr. Spiro brings over 30 years of clinical, healthcare IT, ... for BHI’s cutting-edge analytics solutions. , “I am thrilled to welcome Dr. Spiro ...
(Date:8/16/2017)... ... August 16, 2017 , ... The Data Council, ... that it was acquired by Advantage Solutions. The Data Council’s IX-ONE platform ... include the industry’s leading suppliers, brokers, distributors and retailers. The Data Council will ...
Breaking Medicine News(10 mins):
(Date:8/17/2017)... -- Bio-Ess Laboratories, LLC Chief Science Officer, Dr. Adam Elhofy , ... on Cell-Ess® Universal Titer Boost at the 9 th ... August 21-25.  The Bioprocessing Summit convenes more than 1,000 international bioprocess professionals ... ... Cell-Ess is ...
(Date:8/15/2017)... -- AccuGenomics, Inc., a diagnostic company based in ... company has provided an AccuKit to the HIV Cure ... Hill and to Qura Therapeutics for evaluation in HIV ... reservoir and viral expression in human CD4+ T cells ... is a joint initiative between the University of North ...
(Date:8/10/2017)... -- Physical Rehabilitation Network (PRN), acquired the long-standing outpatient rehabilitation clinic, ... . The reputable clinic will continue to be co-owned and ... staff of four clinicians. Lipkin received his doctorate in physical ... years of experience with a strong background in manual therapy. ... 10th PRN clinic in and around the Denver ...
Breaking Medicine Technology: