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Abbott's TRILIPIX(R) (Fenofibric Acid) in Combination With Rosuvastatin Calcium Helps Patients With Mixed Dyslipidemia and Type 2 Diabetes Meet American Diabetes Association Lipid Targets
Date:6/8/2009

ved TRILIPIX in combination with rosuvastatin to those who received the corresponding dose of rosuvastatin alone, the pre-determined monotherapy. The ADA lipid targets included LDL less than 100 mg/dL, triglycerides less than 150 mg/dL and HDL greater than 40 mg/dL for men and greater than 50 mg/dL for women.

About the Study Results

More patients simultaneously achieved all three ADA lipid targets for HDL, triglycerides and LDL when receiving TRILIPIX in combination with rosuvastatin 10 mg (28.3 percent vs. 8.3 percent; p=0.012) or 20 mg (19.1 percent vs. 5.9 percent; p= 0.045) compared to rosuvastatin 10 mg or 20 mg alone, respectively. Additionally, TRILIPIX in combination with rosuvastatin 5 mg resulted in 21.7 percent of patients achieving all three ADA lipid targets simultaneously compared to 12.1 percent of patients receiving rosuvastatin 5 mg alone (p=0.137). TRILIPIX monotherapy resulted in 4.3 percent of patients obtaining simultaneous achievement of these goals.

"The clinical program continues to generate important data supporting the use of TRILIPIX in combination with rosuvastatin therapy in high risk patient populations," said Eugene Sun, M.D., vice president, Global Pharmaceutical Clinical Development, Abbott.

TRILIPIX Clinical Development Program

The TRILIPIX clinical program studied 3,458 patients with mixed dyslipidemia in four 12-week controlled studies where patients received TRILIPIX alone, TRILIPIX in combination with one of the three most commonly prescribed statins (atorvastatin, simvastatin or rosuvastatin) or statin alone. The clinical program also included a 52-week, long-term, open-label extension study.

Important Safety Information About TRILIPIX

TRILIPIX should not be taken by people with liver, gallbladder, or severe kidney disease, nursing mothers, or those allergic to any product ingredient. Unexplained muscle pain,
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SOURCE Abbott
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