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Abbott Study Examines Rates of Uveitis (Inflammation of the Eye) in Ankylosing Spondylitis Patients Treated with HUMIRA(R) (adalimumab)
Date:11/8/2007

ammation of the spine. Ankylosing means "stiff or rigid" and spondylitis means "inflammation of the spine." Advanced AS can lead to new bone formation on the spine causing the spine to fuse in a fixed position. Typically, the first symptoms of AS are gradual and can include frequent pain and stiffness in the lower back and buttocks. In addition to back pain, other symptoms can include inflammation of joints or tendons, weight loss, fatigue, and eye inflammation (uveitis).

AS affects an estimated 129 out of 100,000 people in the United States and commonly develops between the ages of 15 and 40. Men are three times more likely than women to develop AS. Although the course and severity of AS varies from person to person, some patients with progressive AS can develop spinal deformities leading to significant disability.

The cause of AS is not known, though genetics may play a role: 90 percent of people with AS share a common genetic marker, but having this genetic marker does not mean a person will develop the disease.

Important Safety Information

Serious infections, sepsis, tuberculosis (TB) and opportunistic infections, including fatalities, have been reported with the use of TNF-blocking agents, including HUMIRA. Many of these serious infections have occurred in patients also taking other immunosuppressive agents that in addition to their underlying disease could predispose them to infections. Infections have also been reported in patients receiving HUMIRA alone. Treatment with HUMIRA should not be initiated in patients with active infections. TNF-blocking agents, including HUMIRA, have been associated with reactivation of hepatitis B (HBV) in patients who are chronic carriers of this virus. Some cases have been fatal. Patients at risk for HBV infections should be evaluated for prior evidence of HBV infections before initiating HUMIRA. The combination of HUMIRA and anakinra is not recommended and patients using HUMIRA should not receive live v
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