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Abbott Study Examines Rates of Uveitis (Inflammation of the Eye) in Ankylosing Spondylitis Patients Treated with HUMIRA(R) (adalimumab)
Date:11/8/2007

er 100-patient-years (100-PYs), which represent the number of flares that would occur in 100 patients observed or treated for one year. The rate of uveitis flares was reduced by approximately half during treatment with HUMIRA compared with the rate prior to the trial (15 flares/100-PY to 7.4 flares/100-PY in the entire trial population, 68.4 flares/100-PY to 28.9 flares/100-PY in the subset with a history of uveitis).

Overall, 27 adverse events of uveitis were reported for 25/1,250 patients. Two of the 25 patients experienced an attack of uveitis for the first time. In both patients, the general AS disease activity was high at time of the anterior uveitis episode.

"Uveitis is a fairly common and potentially serious complication of ankylosing spondylitis," said Martin Rudwaleit, M.D., of the Charite University Hospital in Germany and lead author of the trial. "This study is an example of the research needed to better understand this condition and the impact it has on these patients."

About RHAPSODY

RHAPSODY (Review of safety and effectiveness witH Adalimumab in Patients with active ankylosing SpOnDYlitis) is a prospective, multi-national, open-label trial designed to examine the effectiveness of HUMIRA in treating the signs and symptoms of the disease in a large number of patients (n=1,250) with active AS despite previous standard treatment, including patients with uveitis (n=274), in real-life clinical practices.

About Uveitis

There are three different types of uveitis based on the part of the eye involved, including anterior, posterior or intermediate. Acute anterior uveitis occurs in up to 40 percent of patients with AS. Symptoms include pain, light sensitivity, blurry vision or reduced vision; severe complications may include high eye pressure, cataracts, or glaucoma, which can lead to permanent loss of vision.

About Ankylosing Spondylitis

Ankylosing spondylitis (AS) is a type of arthritis that primarily causes infl
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