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Abbott Researchers Target Neuronal Nicotinic Receptors for Treatment of Pain and Cognition
Date:11/1/2007

utics:

Alpha 4 Beta 2 NNR Agonist Program

ABT-089 is a partial and selective NNR agonist, which targets the Alpha 4 Beta 2 NNR subtype. It has demonstrated efficacy in preclinical models of attention, learning and memory deficits. It also has demonstrated efficacy in improving the core symptoms of attention-deficit hyperactivity disorder in adults. ABT-089 is currently in Phase II clinical trials for adult attention-deficit hyperactivity disorder and is being studied for other cognitive diseases.

ABT-894 is an NNR agonist, which targets the Alpha 4 Beta 2 NNR subtype. It has demonstrated efficacy in multiple preclinical animal models of neuropathic pain and nociceptive pain with and without an inflammatory component. ABT-894 exhibits high affinity for and full functional efficacy at the Alpha 4 Beta 2 NNR subtype. Similar to other NNR agonists, it also has demonstrated a cognitive enhancing profile in pre-clinical models of cognition. ABT-894 is currently in Phase II clinical trials for adult attention-deficit hyperactivity disorder and diabetic neuropathic pain. This compound was discovered in collaboration with NeuroSearch.

Alpha 7 NNR Agonist Program

ABT-107 promises to be a potent and selective NNR agonist, which targets the Alpha 7 NNR subtype. It has demonstrated efficacy in in vivo studies that model memory consolidation, social recognition memory, working memory, and sensory gating deficits, which are domains of cognition negatively impacted in Alzheimer's disease and schizophrenia. ABT-107 is currently in Phase I clinical trials for a variety of central nervous system disorders. This compound was discovered in collaboration with NeuroSearch.

D3 Receptor Antagonist Program

In addition to the focus on NNR research, Abbott has an aggressive pre-clinical and clinical program evaluating selective D3 receptor antagonists. D3 receptors are expressed in brain regions associated with schizophrenia, and most current antipsych
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