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Abbott Researchers Target Neuronal Nicotinic Receptors for Treatment of Pain and Cognition
Date:11/1/2007

cal nAChR Pharmacology

Michael W. Decker, Abbott (Friday, Nov. 2, 10 a.m.)

Clinical Studies with nAChR Ligands in ADHD

Timothy E. Wilens, Harvard Medical School (Friday, Nov. 2, 10 a.m.)

"While many advances have been made in the treatment of neurobehavioral disorders, considerable unmet medical need still exists," said Timothy Wilens, M.D., associate professor of Psychiatry, Harvard Medical School. "NNR agonist compounds have the tremendous potential of improving the core and associated symptoms of attention-deficit hyperactivity disorder without apparently producing cardiovascular effects and other more common side effects such as insomnia and appetite suppression observed with current treatments."

"Preclinical and clinical data support the potential of NNR agonists to alleviate the cognitive deficits associated with a variety of disorders, as well as pain," said James Sullivan, Ph.D., divisional vice president, Neuroscience Discovery, Abbott. "Abbott has significant experience in this area and has been among the leaders in advancing the understanding of the therapeutic potential of NNRs for more than a decade. Our scientists have been at the forefront of identifying selective NNR agonists and have published more than 75 research studies in this area."

Abbott Neuroscience

Building on the company's strong scientific foundation in neuroscience and pain, Abbott has significant research and development efforts underway to investigate new therapeutic approaches to cognitive disorders, such as attention-deficit hyperactivity disorder, Alzheimer's disease and schizophrenia. Abbott also is investigating new therapies for nociceptive pain conditions such as osteoarthritis and cancer pain, as well as neuropathic pain conditions such as diabetic neuropathy.

The following investigational programs are examples of Abbott's broad portfolio of neuroscience and pain care research. These programs include and extend beyond NNR therape
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SOURCE Abbott
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