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Abbott Begins U.S. Study of XIENCE V(TM) Drug Eluting Stent Designed for Small Vessels
Date:12/17/2008

tes. The primary endpoint is a composite measure of cardiac death, heart attack (target vessel myocardial infarction) and target lesion revascularization (repeat procedures on the treated vessel) at one year.

XIENCE V in Small Vessels

Observational data supporting the safety and efficacy of XIENCE V in the treatment of coronary artery disease in small vessels was presented at the 2008 Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium in October. James B. Hermiller, M.D., director, Cardiac Catheterization Labs, The Care Group at St. Vincent Hospital in Indianapolis, and an investigator of the SPIRIT III trial, presented subgroup data from the SPIRIT III trial comparing XIENCE V to the TAXUS(R) Express2(TM) Paclitaxel-Eluting Coronary Stent System (TAXUS) in patients with small vessels. In this subgroup analysis, patients were treated with a 2.5 mm stent system and had an average reference vessel diameter of 2.36 mm.

"In the SPIRIT III subgroup analysis, XIENCE V performed extremely well in small vessels. Compared to TAXUS, XIENCE V reduced in-stent late loss, or vessel re-narrowing, by 80 percent eight months after the procedure, and reduced major adverse cardiac events by 74 percent at nine months," said Dr. Hermiller. "When you consider these trends, the availability of a smaller XIENCE V stent system specifically designed to treat lesions in small vessels has the potential to significantly improve patient care."

The SPIRIT III small vessel subgroup analysis demonstrated the following key results for XIENCE V:

-- An observed 80 percent reduction in in-stent late loss compared to TAXUS at eight months (0.11 mm for XIENCE V vs. 0.54 mm for TAXUS, p-value=0.011)*.

-- An observed 74 percent reduction in major adverse cardiac events (MACE) compared to TAXUS at nine months (3.2 percent for XIENCE V vs. 12.5 percent for TAXUS, p-value=0.017)*.
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SOURCE Abbott
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