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AZOR(TM) Receives FDA Approval for Treatment of High Blood Pressure
Date:9/27/2007

ose blood pressure remains too high on currently prescribed medications."

AZOR combines the complementary actions of the powerful CCB amlodipine which inhibits the entrance of calcium into the blood vessel walls, with olmesartan medoxomil, which blocks angiotensin II receptors. Angiotensin II is a hormone that causes blood vessels to tighten and narrow. Together the two medicines relax the blood vessels so that blood can flow more easily. Benicar (olmesartan medoxomil), Daiichi Sankyo's flagship ARB product, is the fastest growing medication in the fastest growing class of blood pressure- lowering drugs.(4)

"The approval of AZOR represents an important milestone for our growing U.S. organization and underscores our continued commitment to helping more patients reach their recommended blood pressure treatment goals," said Joseph P. Pieroni, President and CEO of Daiichi Sankyo, Inc.

High blood pressure can cause permanent changes to blood vessels and the heart that may create serious problems elsewhere in the body.(5) Hypertension is one of the most prevalent conditions in the United States affecting approximately one in three American adults and approximately one billion people worldwide.(6)(7) It is often difficult to control, and of those diagnosed with high blood pressure, approximately 65 percent do not have the condition under control.(8) The number of people with high blood pressure is expected to reach about 1.6 billion worldwide by 2025.(9)

AZOR is indicated for the treatment of hypertension, alone or with other antihypertensive agents. AZOR is not indicated for the initial therapy of hypertension.

Daiichi Sankyo, Inc. and Forest Laboratories, Inc. signed a letter of intent in August to co-promote AZOR in the United States.

IMPORTANT SAFETY INFORMATION ABOUT AZOR

USE IN PREGNANCY

When used in pregnancy, during the second and third trimesters, drugs that act directly on the renin-angiotensin system can cause inju
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SOURCE Daiichi Sankyo, Inc.
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