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AUA 2008: Maxi-K gene transfer may prove to be safe and effective erectile dysfunction treatment
Date:5/14/2008

ORLANDO, FL, May 20, 2008- Maxi-K gene therapy may be a safe and effective future option for men whose erectile dysfunction (ED) is not treatable with oral therapy. Two studies presented today at the 103rd Annual Scientific Meeting of the American Urological Association (AUA) may give hope to these individuals. Researchers presented their findings to reporters in a special press conference on May 20, 2008 at 10 a.m.

Maxi-K therapy is a unique, locally administrated gene-transfer technology to treat erectile dysfunction (ED). The safety and the restorative effects of the treatment have been shown by data from participants in a phase I trial. In some men, the effect lasted up to six months. The gene therapy appears safe as no transfer-related adverse events were reported more than two years after the transfer in some subjects. Unlike conventional oral therapies for men with ED, Maxi-K therapy does not require prior planning, fosters sexual spontaneity and can be used by men taking heart medication.

Researchers not only provided follow-up to previous studies on Maxi-K therapy in men, but also explored whether increased erectile function enhanced other areas of sexual behavior. Male cynomulgus monkeys with ED were observed during their injection period and while in the presence of estrogen-implanted females. Researchers observed and measured the monkeys number of ejaculations, time to ejaculation, number of mounts, time to first mount, number of thrusts, number of sexual invitations by the female and number of erections achieved. Researchers observed dramatic changes after gene transfer, including increases in the number of partial and full erections and a two-fold increase in erection duration. An increase in intimacy was also seen. The data imply that increased erectile function per se may lead to increased sexual function.

This study gives hope to men who experience ED but have not responded to oral therapies, said Arnold Melman, M.
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Contact: Lacey Holt
lholt@auanet.org
American Urological Association
Source:Eurekalert

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