Navigation Links
AUA 2008: Maxi-K gene transfer may prove to be safe and effective erectile dysfunction treatment
Date:5/14/2008

ORLANDO, FL, May 20, 2008- Maxi-K gene therapy may be a safe and effective future option for men whose erectile dysfunction (ED) is not treatable with oral therapy. Two studies presented today at the 103rd Annual Scientific Meeting of the American Urological Association (AUA) may give hope to these individuals. Researchers presented their findings to reporters in a special press conference on May 20, 2008 at 10 a.m.

Maxi-K therapy is a unique, locally administrated gene-transfer technology to treat erectile dysfunction (ED). The safety and the restorative effects of the treatment have been shown by data from participants in a phase I trial. In some men, the effect lasted up to six months. The gene therapy appears safe as no transfer-related adverse events were reported more than two years after the transfer in some subjects. Unlike conventional oral therapies for men with ED, Maxi-K therapy does not require prior planning, fosters sexual spontaneity and can be used by men taking heart medication.

Researchers not only provided follow-up to previous studies on Maxi-K therapy in men, but also explored whether increased erectile function enhanced other areas of sexual behavior. Male cynomulgus monkeys with ED were observed during their injection period and while in the presence of estrogen-implanted females. Researchers observed and measured the monkeys number of ejaculations, time to ejaculation, number of mounts, time to first mount, number of thrusts, number of sexual invitations by the female and number of erections achieved. Researchers observed dramatic changes after gene transfer, including increases in the number of partial and full erections and a two-fold increase in erection duration. An increase in intimacy was also seen. The data imply that increased erectile function per se may lead to increased sexual function.

This study gives hope to men who experience ED but have not responded to oral therapies, said Arnold Melman, M.D., one of the studys authors. The importance of these observations in clinical and pre-clinical trials is that it appears that gene transfer with the Maxi-K channel enhances both erectile capacity as well as other important measures of sexual behavior.

Researchers also presented updated data reaffirming that human patients being treated with hMaxi-K therapy for ED were not adversely affected. The trial, conducted with 11 men between the ages of 18 and 65 with moderate to severe ED who received previous unsuccessful treatment, concluded that direct, organ-targeted, naked DNA gene transfer with hMax-K produced no treatment-related adverse events and the treatment is not associated other diseases or conditions. These results open the door to further testing involving Maxi-K gene transfer and could lead to its effective use in treating the human population.


'/>"/>

Contact: Lacey Holt
lholt@auanet.org
American Urological Association
Source:Eurekalert

Related medicine news :

1. Election 2008: Sleep deprivation a tough opponent for presidential candidates
2. First Quarter of 2008: Draeger Improves Order Intake and Net Sales
3. AUA 2008: Low cholesterol leads to lower PSA
4. AUA 2008: Access to urologists and prostate cancer screenings lead to better outcomes for patients
5. AUA 2008: Uric acid stones may indicate arteriosclerotic diseases
6. AUA 2008: Global warming may lead to increase in kidney stones disease
7. AUA 2008: Gastric bypass surgery restores sexual function in morbidly obese men
8. GSI Securitization Completes Merger and Domicile Transfer
9. XShares Group LLC to Begin the Transfer of HealthShares(TM) NYSE-Listed ETFs to NYSE Arca
10. FDA Inspects Hoviones Technology Transfer Center in New Jersey
11. Final of EPSRCs 2007 Knowledge Transfer Challenge Awards
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... May 26, 2016 , ... Leadership of ... today announced the organization has earned its ISO 13485 certification, indicating the company’s ... with all rules and policies associated with ISO quality standard 13485. , ...
(Date:5/26/2016)... ... May 26, 2016 , ... The Lung Institute has partnered ... cessation class starting June 6 at their clinic in downtown Tampa. The class is ... the Lung Institute has created a free downloadable 4 Week Smoking Cessation Guide ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... offering campers a multitude of activities from daily practices, arts & crafts, discussions, ... Camp Directors Amber East-D’Anna and Christy Evans have combined backgrounds in kids’ yoga, ...
(Date:5/26/2016)... ... May 26, 2016 , ... The MIAMI Institute for Age ... speaker Dr. Adonis Maiquez MD, ABAARM. Dr. Adonis , Wellness Physician of the ... a member of the Institute for Functional Medicine. , He also heads up FITTLab, ...
(Date:5/26/2016)... ... 2016 , ... Power Systems, a leading developer and supplier ... Course in Stoughton, Massachusetts. The course was led by Power Systems’ Education Coordinator, ... interactive course to qualify participants as certified PowerWave trainers. , PowerWave is ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... India , May 25, 2016 ... Animation Market by Type (3D, 2D, 4D), by Therapeutic ... Education), by End User (Medical Device Manufacturers, Hospitals/ Clinics) ... studies the global Medical Animation Market for the forecast ... to reach USD 301.3 Million by 2021 from USD ...
(Date:5/25/2016)... 2016  According to Kalorama Information, the world ... 2015.  Though these are challenging times in the ... success for companies that remain optimistic and seek ... growth prospects medical device companies spend a higher ... (R&D) than do companies in other industries.  Also, ...
(Date:5/25/2016)... , May 25, 2016 Digital ... issuance to it by the US Patent and ... company,s technology includes proprietary processes for electronic opt-­in ... health and wellness programs, HIPAA compliance and otherwise. ... "Our technology allows ...
Breaking Medicine Technology: