Navigation Links
ATS, ERS issue official standards for the quantitative assessment of lung structure

The ATS and the European Respiratory Society have issued official standards for the quantitative assessment of lung structure.

"This is the first concise state-of-the-art review of stereological methods for lung morphometry that formulates practical guidelines for the use of advanced imaging techniques," said ATS past president, John Heffner, M.D. "The proposed standards ensure that the three dimensional window into the lung offered by advanced imaging techniques will provide the sharp and clear view necessary for the discovery of new respiratory cures."

The research policy statement was published in the February 15, 2010, issue of the American Journal of Respiratory and Critical Care Medicine.

Lung morphometrythe study of the structure of the lung on the whole-organ levelis of growing importance as new advanced imaging techniques provide investigators glimpses of previously inaccessible areas of lung architecture. The lung is composed of networks of increasingly tiny airways which, if laid out end-to-end, would extend for 1,500 miles, as well as tiny air sacs called alveoli which, if flattened, would have the surface area of a tennis court. However, these tremendously complex and intricate structures comprise only 10 to 15 percent of the volume of an inflated lung. The rest is air.

"When I look into a microscope at about 200 times magnification and observe a histological section of human lung tissue, I see kind of a network of thin bands that I suspect to represent the walls between airspaces, the empty-looking areas; and some of the network bands mysteriously have free ends," explained Ewald R. Weibel, M.D., D.Sc., who is senior author of the standards and professor emeritus at the Institute for Anatomy at the University of Berne in Switzerland.

New advanced lung imaging techniques offer genuine three-dimensional views of the lung, and because of their ready availability, these techniques provide investigators with tremendous opportunities to look into previously inaccessible crevasses of the whole lung and examine spatial displays of the relationship between tissues, cells, organelles, alveoli, airways and blood vessels. But if these imaging techniques are misapplied they can promote misinterpretations of findings and confuse investigators in the field. Correctly interpreting these images is of critical importance to understanding the exact structures of airways and alveoli.

"Stereology now tells us that the length of this two-dimensional contour of air spaces images (per unit area of section) is proportional to the surface area of the three-dimensional airspaces (per unit volume of lung tissue)," said Dr. Weibel. "This allows the alveolar surface, functionally the gas exchange surface, to be measured on thin sections with great precision. But because the relationship is a statistical one, there are strict rules that must be observed if such an indirect estimate of a three-dimensional surface area is to be accurate. These standards explain these rules."

"The standards also promote the quality of basic and translational lung research, particularly because the potential use of the methodological standards in the modern imaging modalitiessuch as high-resolution CT, MRI and PETare outlined," Dr. Weibel continued. "If adopted by the research community, the standards should also improve the efficiency and accuracy of studies and, most importantly, make results obtained by different groups comparable, thus facilitating interdisciplinary and international collaboration."


Contact: Keely Savoie
American Thoracic Society

Related medicine news :

1. Annals of Internal Medicine tip sheet for Aug. 21, 2007, issue
2. Donate Life America Dispels Myths About Organ & Tissue Donation Among Hispanics During National Hispanic Heritage Month
3. College Mental Health Expert and Sister of Student Who Died By Suicide Available to Discuss College Mental Health Issues
4. AHCA: Rescinding $2.7 Billion Medicare Cuts Top Issue for Fall Legislative Agenda
5. Jump in Youth Suicide Prompts National Childrens Charity KidsPeace to Issue Tips on Prevention, Warning Signs
6. USC researcher identifies stem cells in tendons that regenerate tissue in animal model
7. PowerBar Issues Open Call for 2008-2009 PowerBar Team Elite(TM) Athlete Sponsorship Program
8. Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on Tapestry Pharmaceuticals, Inc.
9. American Red Cross Issues Blood Supply Alert
10. OSHA Issues Draft Ergonomics Guidelines on Preventing Musculoskeletal Injuries in Shipyards
11. Arbios Systems, Incs Q2/07 Analyst Review Issued by Scimitar Equity Research, Inc.
Post Your Comments:
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice ... "Film editors can give their videos a whole new perspective by using the ... of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to ...
(Date:6/25/2016)... ... 2016 , ... Austin residents seeking Mohs surgery services, can now turn to ... Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to ... fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of ...
(Date:6/25/2016)... Oklahoma (PRWEB) , ... June 25, 2016 , ... ... both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures ... Oklahoma City area —Johnson is one of the first doctors to perform the ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Consumers have ... and regulators/payers have placed more emphasis on patient ... patient support programs in the pharmaceutical industry have ... medications. Consequently, pharmaceutical companies are focusing on becoming ... are providing products and services that improve health. ...
(Date:6/24/2016)... CAMBRIDGE, Mass. , June 24, 2016 /PRNewswire/ ... the Spaulding Rehabilitation Network,s Dean Center for ... of Physical Medicine and Rehabilitation, MIT Hacking Medicine, ... Center for Innovation, today announced the five finalists ... Hackathon for Lyme disease.  More than 100 scientists, ...
(Date:6/24/2016)... , June 24, 2016 The Academy of ... recommendations that would allow biopharmaceutical companies to ... entities that make formulary and coverage decisions, a move ... of new medicines. The recommendations address restrictions ... appear on the drug label, a prohibition that hinders ...
Breaking Medicine Technology: