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ASU leads $5 million NIH-sponsored research initiative to advance diabetes care and treatment
Date:11/1/2011

inical studies to advance the difficult search for markers that may be useful for both diagnosis and for assessing potential new drug therapies."

The study will examine and validate biomarkers in people with diabetes, some of whom will have had a heart attack. It is unlikely that a single biomarker will have enough predictive power to assess heart attack risk; rather, panels of biomarkers will be needed to identify drug targets.

"There is a great need for more-effective biomarkers of macrovascular complications of diabetes and for surrogate indicators of favorable response to potential diabetes therapies," said Peter Reaven, M.D., who will oversee the selection of target biomarkers and clinical work, including patient recruitment at the Phoenix VA Health Care System. "Our goal is to identify novel proteins and relevant protein modifications that reflect many of the critical mechanisms that underlay vascular disease in diabetes to develop a more comprehensive panel of biomarkers. One advantage to our team approach is that it will integrate, from the very beginning, the many aspects and disciplines required for a pipeline of biomarker discovery, validation and translation." Pfizer will play a key role in translating prognostic biomarkers of cardiovascular disease risk for decision-making during drug development for type 2 diabetes.

"Prognostic markers of cardiovascular disease risk have been an essential need for type 2 diabetes drug development ever since Nissen published his influential report suggesting some drugs may increase heart attack rates," said Jim Pearson, Ph.D., head of Personalized Medicine at Pfizer in Kalamazoo, MI. "The FDA now requires patients with a higher risk for cardiovascular events to be enrolled in Phase III clinical trials for two years instead of three-to-six months. The problem is that a useful directed proteomics CVD risk panel has yet to be translated. A biomarker panel that is more comprehensive than HbA1c
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Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-727-0369
Arizona State University
Source:Eurekalert  

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