Navigation Links
ASTRO publishes whole breast irradiation guidelines
Date:8/4/2010

The American Society for Radiation Oncology (ASTRO) has released evidence-based guidelines to define appropriate fractionation of whole breast irradiation (WBI), finding that hypofractionated (HF) WBI is effective for many patients with early-stage breast cancer. These guidelines are published in the International Journal of Radiation OncologyBiologyPhysics, the official journal of ASTRO.

Studies have shown that WBI following breast conserving surgery lowers the risk of tumor recurrence and improves survival. Most studies used conventionally fractionated (CF) radiation, which involves daily treatments for up to seven weeks. Despite its effectiveness, conventional fractionation has some drawbacks, including the inconvenience associated with undergoing treatment for a long period of time and the total costs, including both direct health care expenditures and opportunity costs to the patient from being away from home and work.

HF-WBI is a type of WBI that uses a higher dose for each treatment but fewer total treatments, so patients can typically finish radiation in four weeks or less. Several trials have found little difference in the local control and survival outcomes for selected patients treated with either CF-WBI or HF-WBI.

The ASTRO Health Services Research Committee convened a task force and answered the questions:

  1. Which patients obtain equivalent results from HF-WBI and CF-WBI?
  2. What is the role of a tumor-bed radiation boost in patients treated with HF-WBI?
  3. What are appropriate regiments for HF-WBI and tumor-bed boost?
  4. What are the characteristics of an acceptable radiotherapy plan for patients treated with HF-WBI?
  5. What insights relevant to the radiobiology of breast cancer can be gained from recently published clinical trials comparing CF-WBI with HF-WBI?

The task force concluded that HF-WBI is just as effective as CF-WBI for early-stage breast cancer patients who meet specific criteria. These criteria include age 50 years and older, stage T1-2 N0, not receiving chemotherapy, relatively uniform delivery of the radiation dose and the ability to exclude the heart from the path of the radiation beam. For patients who do not meet these criteria, there was not enough evidence to reach a consensus for or against the use of HF-WBI.

"Widespread adoption of HF-WBI for appropriately selected patients has the potential to enhance the convenience of treatment and lower the costs of WBI," Benjamin D. Smith, M.D., lead author of the study and a radiation oncologist at the University of Texas M.D. Anderson Cancer Center in Houston, said. "For patients where the data to support HF-WBI are not as strong, HF-WBI can still be considered an option but further research is needed."


'/>"/>

Contact: Beth Bukata
bethb@astro.org
703-839-7332
American Society for Radiation Oncology
Source:Eurekalert

Related medicine news :

1. ASTRO names radiologist, ABR president Societys 2010 Honorary Member
2. 5 awarded ASTRO research grants
3. ASTRO announces 2010 Fellows class
4. Optimal surgical procedure for duodenal gastrointestinal stromal tumors
5. What affects the gastrointestinal symptoms in peritoneal dialysis patients?
6. ASTRO applauds MedPAC review of Stark law exception
7. ASTRO participates in FDA meeting on radiation safety
8. Florida radiation council endorses ASTRO patient protection plan
9. ASTRO patient education program recognized by AAA Awards
10. Gulf Oil Spill Goes from Disaster to Catastrophe
11. Larson, McBride named 2010 ASTRO Gold Medalists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... ... April 28, 2017 , ... ... with the Home Care Association of America (HCAOA). This agreement allows HCAOA members ... services, as well as discounts on Accreditation University (AU) educational resources that help ...
(Date:4/28/2017)... (PRWEB) , ... April 28, 2017 , ... ... to announce the integration of Microsoft(R) Word(TM) Online(TM), which enables sleep physicians to ... since it streamlines the reporting process and provides a familiar interface that does ...
(Date:4/28/2017)... ... 2017 , ... Horizon Blue Cross Blue Shield of New Jersey (BCBSNJ) announced ... its outlook as “stable.” At the same time, the ratings agency cautioned that the ... dip below “capital adequacy” thresholds required for its strong rating. , “Horizon is committed ...
(Date:4/28/2017)... ... April 28, 2017 , ... GlycoMark, Inc. announced today ... throughout the Northeast U.S. , GlycoMark is the only clinically available blood ... provides a clinically proven one- to two-week measure of hyperglycemic excursions, often related ...
(Date:4/28/2017)... ... April 28, 2017 , ... Ushio America ... lamps offer an instant energy-saving solution for F32T8 fluorescent lamps on most instant-start ... ballasts. These 50,000 hour rated lamps utilize the existing electronic ballast, saving labor ...
Breaking Medicine News(10 mins):
(Date:4/24/2017)... 2017 Solentim, the developer of instrumentation ... of a major new product line called the ... VIPS has been developed for automatically seeding single ... part of the process to generate clonally-derived cell ... more reliable solution when compared to traditional single ...
(Date:4/20/2017)... , April 20, 2017 ... "Global Biosimilar Pipeline and Market Prospects: Addressing Production ... report to their offering. ... "Global Biosimilar Pipeline and Market Prospects: ... Design" provides an in-depth assessment of the current trends ...
(Date:4/20/2017)... April 20, 2017  AbbVie (NYSE: ABBV), a ... (n=145/146) of chronic hepatitis C virus (HCV) infected ... 6 and compensated cirrhosis (Child-Pugh A) achieved sustained ... ) with its investigational, pan-genotypic regimen of glecaprevir/pibrentasvir ... seen following 12 weeks of G/P treatment without ...
Breaking Medicine Technology: