Navigation Links
ASTRO and SSO issue consensus guideline on margins for breast-conserving surgery with WBI
Date:2/10/2014

Fairfax, Va., February 10, 2014 The American Society for Radiation Oncology (ASTRO) and the Society of Surgical Oncology (SSO) are pleased to announce the publication of the consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer. The guideline document represents an intensive collaboration among experts in the radiation oncology and surgical oncology fields, led by Meena S. Moran, MD, associate professor of the Department of Therapeutic Radiology at Yale School of Medicine in New Haven, Conn., on behalf of ASTRO, and Monica Morrow, MD, SSO immediate past president, breast cancer surgeon and Chief of Breast Surgery at Memorial Sloan-Kettering Cancer Center in New York, co-chairs of the Margin Consensus Panel (MCP). In addition to determining the ideal margin width that minimizes the risk of ipsilateral breast tumor recurrence (IBTR), the guideline outlines an evidence-based surgical treatment path that could reduce unnecessary surgery for patients.

Society of Surgical OncologyAmerican Society for Radiation Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Stages I and II Invasive Breast Cancer uses the results of a meta-analysis of margin width and IBTR from a thorough review of 33 research studies from MEDLINE and evidence-based medicine published from 1965 to January 2013, in the context of outcomes from contemporary trials. The included studies encompassed 28,162 patients with stage I or II invasive breast cancer who were treated with whole-breast irradiation and with a minimum median follow-up time of four years. Patients treated with neoadjuvant chemotherapy or patients with pure ductal carcinoma in situ (DCIS) breast cancer were not included in the research for the guideline.

The consensus guideline was made possible by a research grant from the Susan G. Komen Foundation and underwent extensive peer review prior to approval by the SSO Executive Council and ASTRO's Board of Directors in October 2013. In addition, the American Society of Breast Surgeons and the American Society of Clinical Oncology (ASCO) have both endorsed the guideline. It is available open access online as a PDF document at http://www.redjournal.org, http://www.annsugoncol.org and http://jco.ascopubs.org/, and will be published in the March 1, 2014 print issue of the International Journal of Radiation Oncology Biology Physics (Red Journal), the official scientific journal of ASTRO; the March 2014 print issue of Annals of Surgical Oncology, the official journal of SSO; and the March 10, 2014 issue of the Journal of Clinical Oncology, the official journal of ASCO.

The consensus guideline includes eight clinical practice recommendations: 1) positive margins, defined as ink on invasive cancer or DCIS, are associated with at least a two-fold increase in IBTR. This increased risk is not nullified by delivery of a boost, delivery of systemic therapy or favorable biology; 2) negative margins (no ink on tumor) optimize IBTR. Wider margin widths do not significantly lower this risk; 3) the rates of IBTR are reduced with the use of systemic therapy. In the event that a patient does not receive adjuvant systemic therapy, there is no evidence suggesting that margins wider than no ink on tumor are needed; 4) margins wider than no ink on tumor are not indicated based on biologic subtype; 5) the choice of whole-breast irradiation delivery technique, fractionation and boost dose should not be dependent on margin width; 6) wider negative margins than no ink on tumor are not indicated for invasive lobular cancer. Classic lobular carcinoma in situ (LCIS) at the margin is not an indication for re-excision. The significance of pleomorphic LCIS at the margin is uncertain; 7) young age (≤40 years) is associated with both an increased risk of IBTR after breast-conserving therapy (BCT) and an increased risk of local relapse on the chest wall after mastectomy and is more frequently associated with adverse biologic and pathologic features. There is no evidence that increased margin width nullifies the increased risk of IBTR in young patients; and 8) an extensive intraductal component (EIC) identifies patients who may have a large residual DCIS burden after lumpectomy. There is no evidence of an association between increased risk of IBTR and EIC when margins are negative.

"Our hope is that this guideline will ultimately lead to significant reductions in the high re-excision rate for women with early-stage breast cancer undergoing breast-conserving surgery. Based on the consensus panel's extensive review of the literature, the vast majority of re-excisions are unnecessary because disease control in the breast is excellent for women with early-stage disease when radiation and hormonal therapy and/or chemotherapy are added to a women's treatment plan," said Dr. Moran.

"A significant portion of breast cancer surgeries in the United States are performed by surgical oncologists, and the definition of an adequate margin has been a major controversy. Therefore, it was only natural that we decided to create a definitive guideline that helps to minimize unnecessary surgery while maintaining the excellent outcomes seen with lumpectomy and radiation therapy," said Dr. Morrow. "We are proud to provide this pivotal document to the oncology community, which will improve the lives and treatment of patients touched by this disease."

In addition to Drs. Moran and Morrow, members of the MCP and authors of the Society of Surgical OncologyAmerican Society for Radiation Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Stages I and II Invasive Breast Cancer include Stuart J. Schnitt, MD, of the Department of Pathology at Harvard Medical School, Boston; Armando E. Guiliano, MD, of the Department of Surgery at Cedars-Sinai Medical Center, Los Angeles; Jay R. Harris, MD, FASTRO, of the Department of Radiation Oncology at Harvard Medical School, Boston; Seema A. Khan, MD, of the Department of Surgery at Northwestern University Feinberg School of Medicine, Chicago; Janet Horton, MD, of the Department of Radiation Oncology at Duke University Medical Center, Durham, N.C.; Suzanne Klimberg, MD, of the Department of Surgery at University of Arkansas for Medical Sciences, Fayetteville, Ark.; Mariana Chavez-MacGregor, MD, of the Department of Medical Oncology at the University of Texas MD Anderson Cancer Center, Houston; Gary Freedman, MD, of the Department of Radiation Oncology at University of Pennsylvania School of Medicine, Philadelphia; Nehmat Houssami, MD, PhD, of the School of Public Health at the University of Sydney Medical School, New South Wales, Australia; and Peggy L. Johnson, Advocate in Science, Susan G. Komen, Wichita, Kan.

"We appreciate the dedicated efforts of Drs. Moran and Morrow for leading an exemplary team to produce this valuable guideline from both specialty organizations," said Colleen A.F. Lawton, MD, FASTRO, chair of ASTRO's Board of Directors. "Society of Surgical OncologyAmerican Society for Radiation Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Stages I and II Invasive Breast Cancer is an essential tool for every practice to provide the necessary context and variables in order to provide high quality, patient-centered care."


'/>"/>

Contact: Michelle Kirkwood
press@astro.org
703-286-1600
American Society for Radiation Oncology
Source:Eurekalert

Related medicine news :

1. New research on diverticular disease in the December issue of Clinical Gastroenterology and Hepatology
2. It’s a Bird, It’s a Plane, It’s a… Buddhist Monk? Crowd Gathers in the Castro for “The Temple” Book Launch
3. MEDIVATORS Inc. and Edison Nation Medical Search for New Medical Invention Ideas to Improve Detection of Lower Gastrointestinal Diseases; Search Concludes Jan. 20, 2014
4. Scientists show how cells protect their DNA from catastrophic damage
5. Gastrointestinal Bleeding Market: Global Clinical Trials Review H2 2013 in New Research Report at RnRMarketResearch.com
6. gGastro Receives ONC-ACB Certification by Drummond Group
7. ASTRO/AUA joint guideline for RT after prostatectomy highlighted at ASTRO Annual Meeting
8. Memorial Cancer Institute to Demonstrate Highly Reliable, Highly Efficient Culture at ASTRO Conference
9. 2 Georgia cancer patient support organizations to receive Survivor Circle grants from ASTRO
10. Atlanta cancer survivor and volunteer will be honored with ASTROs 2013 Survivor Circle Award
11. Miraca Life Sciences Announces Significant American College of Gastroenterology Tradeshow Plans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2017)... ... June 20, 2017 , ... After months of negotiations, FaceCradle USA is proud to ... on Wednesday, June 21. , “Introducing our product on QVC is something we all worked ... our travel pillow to more than 90 million homes in the United States,” said FaceCradle ...
(Date:6/20/2017)... ... June 20, 2017 , ... ... the introduction of school choice can promote economic development in economically distressed urban ... has, according to the report, contributed to the economic development of the city ...
(Date:6/20/2017)... ... 2017 , ... Dr. Manju R. Kejriwal currently accepts new ... or not they have a referral. Dr. Kejriwal offers state-of-the-art treatment through the ... bacteria and damaged tissue without affecting the surrounding tissue. This technology virtually eliminates ...
(Date:6/20/2017)... ... 20, 2017 , ... Many RNA binding proteins (RBPs) regulate ... team developed expressRNA, a web platform encompassing computational tools for integration of the ... the ‘RNA maps’, which demonstrate that RBPs bind to specific positions on pre-mRNAs ...
(Date:6/20/2017)... ... June 20, 2017 , ... John D'Eri, CEO of Rising Tide ... Adult Autism Award during the Autism Society of America 's 49th annual ... Daniel Jordan Fiddle Foundation (DJFF) was founded in 2002 as the nation's first ...
Breaking Medicine News(10 mins):
(Date:6/19/2017)... 2017  Researchers from DRUGSCAN ® and INC ... a live, complimentary webinar titled, "Untangling methods to tamper ... real world" on Wednesday June 28, 2017 from 12:00 ... webinar will feature interviews with recreational and dependent prescription ... techniques abusers use to prepare opioid tablets for routes ...
(Date:6/14/2017)... 14, 2017  ivWatch LLC, a medical device company ... (IV) therapy, is pleased to announce it was the ... Hospital Supplies and Equipment at the 2017 Medical Design ... medtech industry. The award was presented by Medical Device ... Center in New York during ...
(Date:6/13/2017)... , June 13, 2017 Zimmer Biomet Holdings, Inc. ... today announced that the U.S. Food and Drug Administration (FDA) ... 3, 2015 relating to its Zhejiang, China ... "The successful clearance of the Warning Letter ... manufacturing facility is a measure of the progress we have ...
Breaking Medicine Technology: