Navigation Links
ASTRO: Deviating from radiation protocols increases risk of treatment failure and death
Date:10/30/2012

PHILADELPHIA--Implementing measures to ensure radiation therapy protocols are followed not only decreases deviations, but it can also improve overall survival in cancer patients, Thomas Jefferson University Hospital researchers suggest in a first-of-its kind study presented during a plenary session at the American Society for Radiation Oncology (ASTRO) 54th Annual Meeting in Boston.

Researchers from the Department of Radiation Oncology at Jefferson analyzed radiation therapy protocols, quality assurance (QA) measures and patient outcomes in eight, large clinical trials to determine if such deviations were associated with inferior clinical outcomes.

The findings, presented by Nitin Ohri, M.D., who conducted the research while at Jefferson, but is currently at Albert Einstein/Montefiore Medical Center in New York., revealed that deviating from protocols was associated with up to a 75 percent increased risk of treatment failure and overall mortality. This suggests that implementing QA measures to ensure protocols are followed could improve outcomes for cancer patients, according to the authors.

It is widely accepted that deviating from a radiation therapy protocol in a clinical trial will more than likely result in adverse effects. And, as a result, significant QA measures have been taken over the last several decades to minimize such effects. However, while these measures have shown to decrease deviation, there is currently no data establishing the patient-outcome benefits of those measures. This is the first study, to the author's knowledge, to examine the effects on those measures on risk of treatment failures and mortality.

Examples of radiation therapy deviation include inadequate targeting of high-risk lymph node regions or incorrect dose calculation.

Other authors of the study include Adam P. Dicker, M.D., Ph.D., Chair of the Department of Radiation Oncology at Jefferson and the Kimmel Cancer Center at Jefferson, Laura Doyle, M.S., and Amy Harrison, M.S., of Jefferson's Department of Radiation Oncology, and Timothy Showalter, M.D., and Xinglei Shen, M.D.

The researchers examined two lung cancer trials, three trials for medulloblastoma, and trials for Ewing's sarcoma, pancreatic cancer and head and neck cancer, which included over 2,000 patients in total. They extracted information from the clinical trials, including number of patients included in QA analysis, definition of radiotherapy protocol deviation, and number of patients with and without radiotherapy deviations.

The frequency of radiation therapy deviations, they found, ranged from 8 percent to 71 percent. Those deviations were also associated with a significant decrease in overall survival, and with an approximately 75 percent increase in the risk of treatment failure and mortality.

"The magnitude of these effect sizes demonstrates that delivery of high-quality radiation therapy and having a rigorous QA program is critical for the successful execution of clinical trials and for the effective treatment of all cancer patients," said Dr. Dicker. "With such practices, deviations decrease and thus overall survival rates for cancer patients improve."


'/>"/>
Contact: Steve Graff
stephen.graff@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Related medicine news :

1. Radiation treatment after surgery improves survival for elderly women with early-stage breast cancer
2. Many Mistakenly Think Radiation Might Cure Terminal Lung Cancer
3. Study: No Long-Term Heart Risks From Breast Radiation
4. Mayo Clinic: Antidepressant eases radiation-related mouth pain in head, neck cancer
5. Minorities most likely to have aggressive tumors, less likely to get radiation
6. Fasting makes brain tumors more vulnerable to radiation therapy
7. Stage I NSCLC patients who receive radiation therapy are surviving longer
8. Brain radiation after lung cancer treatment reduces risk of cancer spreading
9. Stem-cell-protecting drug could prevent the harmful side effects of radiation therapy
10. Face-Down Position May Be Safer During Radiation for Breast Cancer: Study
11. Use of regional PACS network associated with lower repeat rates, costs and less radiation exposure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... ... , ... According to the American Society of Plastic Surgeons (ASPS), over one ... 5 most popular minimally-invasive cosmetic procedures in the country. With summer close, it’s safe ... next 8-10 weeks. For anyone considering a hair removal procedure, there are a few ...
(Date:3/30/2017)... ... , ... Nutrition Education for the Public (NEP), a dietetic ... Seafood Nutrition Partnership (SNP) in presenting “Eating Heart Healthy: Exploring Issues of Low ... students inform consumers about the health benefits of eating a seafood-rich diet. ...
(Date:3/29/2017)... WI (PRWEB) , ... March 29, 2017 , ... ARI ... its exclusive provider of co-op eligible dealer websites for its network of more than ... of professional landscaping and agricultural equipment including rotary and flail mowers and cutters, rear ...
(Date:3/29/2017)... ... ... main cause of hay fever in the United States, with an estimated 95 percent of ... July each year; with the worst time for sufferers being June and July. , ... provide an effective defense against grass pollen; they are proven in independent studies to trap ...
(Date:3/29/2017)... ... March 30, 2017 , ... Sports Brand EXOUS Bodygear announced ... retails normally at $29.97; for the remaining days of March, the price will be ... to a special price of just $10 (regular retail price $19.97). , The special ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... N.Y. , March 29, 2017  BioSpecifics ... originated and continues to develop collagenase based-therapies with ... histolyticum (CCH) marketed as XIAFLEX ®  in the ... management will present a corporate overview at the ... on Wednesday, April 5, 2017 at 8:00 a.m. ...
(Date:3/29/2017)... Research and Markets has announced the addition of the "Italy ... report to their offering. ... Proton Therapy Market in Italy will double by ... currently three proton therapy centers in Italy that ... Italy , the first patients were treated with proton beams in ...
(Date:3/29/2017)... 29, 2017 Research and Markets has ... 2014 - 2025" report to their offering. ... The global ... million by 2025. Increasing geriatric population prone to orthopedic diseases ... navigation systems over the forecast period. Osteoarthritis and osteoporosis are ...
Breaking Medicine Technology: