Navigation Links
ASPIRE Phase III trial of vaginal ring to prevent HIV completes enrollment of 2,629 women
Date:6/26/2014

the timeline to the ring's potential approval.

Vaginal rings are flexible products that fit comfortably high up inside the vagina and provide sustained delivery of active agents over a period of time. Vaginal rings are already used in many countries to deliver hormonal contraception. The dapivirine ring adapts that medical technology as a way to offer women potentially long-acting protection against HIV. It is the first long-acting ARV-based product to enter efficacy testing and the first involving an ARV other than tenofovir or a tenofovir combination. Moreover, unlike tenofovir, dapivirine is not a drug used in the treatment of HIV.

"Perhaps the most attractive aspect about a vaginal ring as an HIV prevention method is that women can use it discreetly and use it up to a month at a time due to the slow release of the medication it contains. If the women in our trial find it easy and practical to use consistently, this will be extremely important, because only if it is used as directed are we able to assess its true effectiveness," said Thesla Palanee, Ph.D., ASPIRE protocol co-chair who also directs the study at her own institution, the Wits Reproductive Health and HIV Institute (Wits RHI) in Johannesburg, South Africa..

ASPIRE is completing enrollment with fewer participants than originally planned. The research team had assumed needing to enroll up to 3,476 women to answer the study's primary questions about safety and effectiveness, a calculation based in part on a background HIV incidence rate of 3.9 percent in trial site communities at the time the protocol was being developed. In March 2013, however, when ASPIRE was already seven months into the study, results were reported of another HIV prevention trial called VOICE indicating the HIV incidence in a very similar population was much higher, at 5.7 percent. Adjusting for both the higher HIV incidence as well as the fact that the study has more women than expected using the ring wel
'/>"/>

Contact: Lisa Rossi
rossil@upmc.edu
412-641-8940
Microbicide Trials Network
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. MyPuress Announces Expansion into Canadian Market with Release of Aspiree Product Line
2. ALS patients differ on treatment choices in later phases of disease
3. Reach2HD, a Phase II study in Huntingtons disease, launched
4. Analysis of KRYSTEXXA phase III data demonstrates improved health-related quality of life and physical function in refractory chronic gout patients
5. Phase III trial of dapivirine ring begins in Africa: New HIV prevention approach for women
6. IDRI and Medicago announce authorization to initiate a Phase 1 clinical trial for an H5N1 vaccine
7. COPD Foundation and BWH announces second phase of groundbreaking COPDGene project
8. JDRF announces winners of first phase of Agnes Varis Glucose-Responsive Insulin Challenge
9. Positive results from Phase 1/2 stem cell trial reported
10. New monoclonal antibody inhibits tumor growth in advanced solid tumors in phase I clinical trial
11. Teva to present new Phase III data for QNASL® Nasal Aerosol at the 2012 ACAAI Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... N.Y., Oct. 21 Henry Schein, Inc. (Nasdaq: HSIC ... 2009 financial results before the stock market opens on Wednesday, ... its earnings conference call on the same day beginning at ... will include Stanley M. Bergman, Chairman and Chief Executive Officer ...
... Oct. 21 For a sample of prevention ... are key terms one is suggested to start on: BRCA; ... Progesterone; SHBG; vitamin D. , Some will be covered by ... the keynote ,An Oncologist View of Hormones and Breast Cancer: ...
... ... automated pharmaceutical waste management solution, is pleased to announce that it has made another ... and businesses in the healthcare field who are engaged in reducing their environmental footprints. ... Irvine, CA ...
... 31 ... , ... October 21, 2009 -- A newly-opened online store will sell a wide assortment of gluten ... problem can show up at any age, and once diagnosed, becomes a lifelong battle to ...
... ... medical malpractice insurance premium rates for every major insurer in every county in every ... year; declined in some instances , ... Chicago, IL (PRWEB) October 21, 2009 -- Rates for physicians, 2009-2010 ...
... After New ... ... The members of McDivitt Law Firm care about the safety of everyone in the community--that,s why ... ,McDivitt Law Firm is partnering with Yellow Cab of Colorado Springs to provide free ...
Cached Medicine News:Health News:Henry Schein to Webcast Third Quarter 2009 Conference Call Wednesday, November 4, at 10 A.M. EST 2Health News:Bioidentical Hormones, a True Prevention for Breast Cancer 2Health News:Vestara Joins National Health Organization Practice Greenhealth to Further Support Environmental Practices 2Health News:Vestara Joins National Health Organization Practice Greenhealth to Further Support Environmental Practices 3Health News:Gluten Free Superstore Opens With 4,000 Products 2Health News:Medical Liability Monitor Annual Survey of Medical Malpractice Insurance Rates Shows Medical Liability Insurance Market Remains Soft 2Health News:McDivitt Law Firm's Treat Is No Trick -- Free Rides on Halloween in Colorado Springs 2Health News:McDivitt Law Firm's Treat Is No Trick -- Free Rides on Halloween in Colorado Springs 3
(Date:12/24/2014)...  Conkwest, Inc., the Natural Killer Cell Company ... (NK) cell-line platform, Neukoplast® (NK-92™) as an immuno-oncology ... NantWorks founder, physician scientist and biotechnology entrepreneur, has ... $48 million of the Company,s Class A Common ... be named Co-Chairman of the Conkwest Board of ...
(Date:12/24/2014)... SCHOFIELD, Wis. , Dec. 23, 2014 ... and marketer of over-the-counter (OTC) medicinal and healthcare products, ... production of MigraPure® H, a hemp-based, advanced headache relief ... marijuana dispensaries in Colorado , ... . With the MigraPure H Advanced ...
(Date:12/24/2014)... DALLAS , December 24, 2014 /PRNewswire/ ... Research Report on Global Disposable Syringe Industry ... to its online business intelligence library. ... Global Disposable Syringe Industry is a professional ... Syringe market.  For overview analysis, the report ...
Breaking Medicine Technology:Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 2Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 3Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 4Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 5PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 2PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 2World Disposable Syringe Market 2014 Report: China and Regional Analysis 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 4World Disposable Syringe Market 2014 Report: China and Regional Analysis 5
... are available in two versions. ... a clotting activator and is ... serum is required for testing ... is suitable where the testing ...
Inquire...
... tubes are for the examination of ... for viral load determinations. HIV and ... at room temperature for up to ... is recommended to centrifuge EDTA K2 ...
Glass Whole Blood Tube with K3EDTA...
Medicine Products: