Navigation Links
ASH honors Margaret A. Goodell, Ph.D., with 2012 William Dameshek Prize
Date:8/27/2012

Named after the late William Dameshek, MD, a renowned hematologist, past president of ASH, and first editor of the Society's journal Blood, the William Dameshek Prize is awarded to an individual who has made a recent outstanding contribution to the field of hematology. Dr. Goodell will accept this prestigious award at 9:30 a.m. ET on Tuesday, December 11, 2012, during the 54th ASH Annual Meeting and Exposition in Atlanta.

Dr. Goodell, an internationally recognized leader in hematopoietic stem cell (HSC) biology, currently directs the Stem Cells and Regenerative Medicine Center at Baylor College of Medicine, where she holds the Vivian L. Smith Chair of Regenerative Medicine and serves as Professor of Pediatrics and Molecular & Human Genetics.

As a postdoctoral fellow at the Whitehead Institute for Biomedical Research at the Massachusetts Institute of Technology and Harvard Medical School, Dr. Goodell developed a method for isolating murine HSCs after observing that they discharge a fluorescent dye. This "side population" method has been used by countless labs worldwide for isolating normal and cancer stem cells, and the original publication in the Journal of Experimental Medicine describing the method has been cited more than 2,000 times.

More recently, Dr. Goodell identified the molecular mechanisms that regulate HSC activation. By characterizing the self-renewal cycle of stem cells in response to the chemotherapy drug 5-Fluorouracil, her lab observed gene expression changes during cell activation and identified several classes of genes that appear to be involved in activating the self-renewal process of HSCs. As a number of these newly identified genes were found to be regulated by interferons, proteins that help defend the body against viruses, Dr. Goodell then demonstrated how tight regulation of the interferon regulatory system is required for normal HSC function and how chronic infection directly alters HSC dormancy through the interferon response. This breakthrough provided new insight into how the entire hematologic response is coordinated during infectious stress and demonstrated, for the first time, that HSCs participate in the fundamental immunologic responses that guide the activation of other, more mature cells that fight infection.

These and additional discoveries made by Dr. Goodell and her laboratory have had major implications for both normal and malignant hematology. These breakthroughs have provided new targets for manipulation of normal stem cells and have improved bone marrow transplantation and other therapeutic interventions for cancer.

Dr. Goodell is renowned for her leadership to ASH and the broader hematology community. In addition to serving as a past chair of the ASH Scientific Committee on Stem Cells and Regenerative Medicine, Dr. Goodell has served on the editorial board of Blood, the Society's official journal, and will become an associate editor on January 1, 2013. Beyond her ASH involvement, Dr. Goodell is a founding member of the International Society for Stem Cell Research, where she also served on the board of directors and as chair of the Planning and Audit Committees. She also currently serves as Vice President of the International Society for Experimental Hematology. She has received many honors and awards for her research, including the ASH Scholar Award, the Leukemia & Lymphoma Society's Stohlman Scholar Award, the Ellison Medical Foundation's Senior Scholar Award, the American Heart Association's Established Investigator Award, and the Academy of Medicine, Engineering, and Science of Texas' Edith and Peter O'Donnell Award in Medicine. Dr. Goodell has served as an outstanding mentor to numerous hematology trainees who have gone on to receive more than 70 individual awards, including one ASH Joanne Levy Memorial Award, two ASH Scholar Awards, two Trainee Research Awards, and nine ASH Abstract Achievement Awards.

"Dr. Goodell has made critical contributions to hematology research, particularly in the area of hematopoietic stem cells, where she has transformed the way hematologists understand stem cell biology and how we approach and perform bone marrow transplants," said ASH President Armand Keating, MD, of Princess Margaret Hospital in Toronto. "The Society is honored to present her with this award, as she has consistently demonstrated excellence in research, leadership, and mentoring."


'/>"/>
Contact: Claire Gwayi-Chore
cgwayi-chore@hematology.org
202-776-0544
American Society of Hematology
Source:Eurekalert

Related medicine news :

1. ASH honors Bruce R. Blazar, M.D., and Carl H. June, M.D., with 2012 Ernest Beutler Lecture and Prize
2. Amyotrophic Lateral Sclerosis Association honors Dr. Robert Baloh, M.D.
3. UMMS researcher Victor Ambros, Ph.D., named co-recipient of 2012 Janssen Award for Biomedical Research
4. Dr. William Oh named 2012 Legend of Neonatology
5. ASH awards Timothy J. Ley, M.D., with 2012 E. Donnall Thomas Lecture and Prize
6. American Chemical Society launches 2012 edition of popular Prized Science video series
7. U-Ms Taubman Institute awards inaugural $100,000 translational medical research prize
8. Loyola Med student wins prize for excellence in neurology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... ... ... FileHold's document management software has been implemented by DocuSyst ... for FileHold software that is pay per user subscription-based and also does on-premise ... web services API. DocuSyst also advises clients on fully functioning back up technologies ...
(Date:2/8/2016)... CA (PRWEB) , ... February 08, 2016 , ... ... showing greater than 50% lower incidence rate of type 2 diabetes in the ... averages. ”It is time to make a change in public health,” states Carole ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... TopConsumerReviews.com recently ... in Mole removal products. , Moles are derived from a cluster of melanin when ... all the wrong places and create a lifetime of embarrassment. Historically, mole removal ...
(Date:2/8/2016)... NV (PRWEB) , ... February 08, 2016 , ... Guruji ... February 9th, 10th and 11th, 2016 in honor of his birthday on February 10th. ... true happiness. Mahendra Trivedi is known by over 250,000 people from over 40 ...
(Date:2/8/2016)... ... February 08, 2016 , ... According to research by the ... dental technicians to be certified or obtain continuing education. To increase patient awareness ... In Your Mouth?” campaign to inform dentists and patients about the possible lack ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... , Feb. 8, 2016  Sangamo BioSciences, ... therapeutic genome editing, announced that the U.S. Food ... Investigational New Drug (IND) application for SB-318, a ... therapy for Mucopolysaccharidosis Type I (MPS I). The ... Sangamo to initiate a Phase 1/2 clinical study ...
(Date:2/8/2016)... February 8, 2016 ... published by Allied Market Research titled, "World ... Forecasts, 2014-2020", estimates the world synthetic biology market ... and sequencing technology segment would continue to lead ... tools segment, collectively, held around half of the ...
(Date:2/8/2016)... , 8. Februar 2016  LivaNova, ... heute eine Infografik mit dem Titel „Epilepsy ... Welt), mit der der Krankheit gegenüber ein ... dazu ermutigen soll, Medikamentenresistenz bei Epilepsie auf ... allgemeinen Diskussion zu machen. Mithilfe der neuen ...
Breaking Medicine Technology: