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ASH honors Margaret A. Goodell, Ph.D., with 2012 William Dameshek Prize
Date:8/27/2012

Named after the late William Dameshek, MD, a renowned hematologist, past president of ASH, and first editor of the Society's journal Blood, the William Dameshek Prize is awarded to an individual who has made a recent outstanding contribution to the field of hematology. Dr. Goodell will accept this prestigious award at 9:30 a.m. ET on Tuesday, December 11, 2012, during the 54th ASH Annual Meeting and Exposition in Atlanta.

Dr. Goodell, an internationally recognized leader in hematopoietic stem cell (HSC) biology, currently directs the Stem Cells and Regenerative Medicine Center at Baylor College of Medicine, where she holds the Vivian L. Smith Chair of Regenerative Medicine and serves as Professor of Pediatrics and Molecular & Human Genetics.

As a postdoctoral fellow at the Whitehead Institute for Biomedical Research at the Massachusetts Institute of Technology and Harvard Medical School, Dr. Goodell developed a method for isolating murine HSCs after observing that they discharge a fluorescent dye. This "side population" method has been used by countless labs worldwide for isolating normal and cancer stem cells, and the original publication in the Journal of Experimental Medicine describing the method has been cited more than 2,000 times.

More recently, Dr. Goodell identified the molecular mechanisms that regulate HSC activation. By characterizing the self-renewal cycle of stem cells in response to the chemotherapy drug 5-Fluorouracil, her lab observed gene expression changes during cell activation and identified several classes of genes that appear to be involved in activating the self-renewal process of HSCs. As a number of these newly identified genes were found to be regulated by interferons, proteins that help defend the body against viruses, Dr. Goodell then demonstrated how tight regulation of the interferon regulatory system is required for normal HSC function and how chronic infection directly alters HSC dormancy
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Contact: Claire Gwayi-Chore
cgwayi-chore@hematology.org
202-776-0544
American Society of Hematology
Source:Eurekalert

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