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ASH honors Bruce R. Blazar, M.D., and Carl H. June, M.D., with 2012 Ernest Beutler Lecture and Prize
Date:8/27/2012

hanks to this unprecedented work, several international Phase III clinical trials are now underway using rapamycin to both prevent and treat GVHD. In addition to this groundbreaking work, Dr. Blazar's preclinical GVHD studies led to the clinical testing of non-mitogenic anti-CD3 monoclonal antibody to target GVHD-causing T cells, demonstration that interleukin-10 (IL-10) protein could inhibit GVHD lethality, and keratinocyte growth factor to prevent tissue injury in rodents and humans after allogeneic hematopoietic cell transplantation. More recently, Dr. Blazar has published the first report of a novel population of regulatory T-cells, known as Tregs, that can be expanded ex vivo and used to prevent and eliminate GVHD.

Dr. Blazar has served in a variety of leadership roles within the Society, most recently as co-chair of the 2012 ASH Annual Meeting Scientific Program, and has also served on the editorial board of the Society's journal Blood and as chair of the Scientific Committee on Transplantation Biology. Aside from his involvement within ASH, Dr. Blazar has worked closely with the National Institutes of Health (NIH), having served as chair of the NIH Cancer Immunopathology and Immunotherapy Study Section,co-chair of the National Heart, Lung, and Blood Institute's Panel for Strategic Planning for Cellular Therapies, Board of Scientific Counselors for the National Cancer Institute, and a member of the Food and Drug Administration Biological Response Modifiers Advisory Committee. He is also an elected member of the American Society of Clinical Investigation and the Association of American Physicians.

Over the course of his career Dr. Blazar has received many honors and awards, including an NIH Merit Award, the American Society of Blood and Marrow Transplantation's E. Donnall Thomas Lecture, and as a Fellow of the American Association for the Advancement of Science. He serves as Principal Investigator of numerous NIH R01 grants, including
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Contact: Claire Gwayi-Chore
cgwayi-chore@hematology.org
202-776-0544
American Society of Hematology
Source:Eurekalert

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