Navigation Links
ASH awards Timothy J. Ley, M.D., with 2012 E. Donnall Thomas Lecture and Prize
Date:8/27/2012

Dr. Ley will present his lecture, "The AML Genome," at 9:00 a.m. on Monday, December 10, 2012, at the 54th ASH Annual Meeting and Exposition in Atlanta. His lecture will explore the use of whole genome sequencing in AML, which has offered an unprecedented view of the mutations that cause this disease. His lecture will also focus on next-generation DNA sequencing approaches in AML that are providing detailed information about the clonal architecture of AML at presentation and its evolution at relapse, as well as new clues regarding the genetic underpinnings of drug resistance and disease progression.

Dr. Ley has played a pivotal role in advancing the translational field of cancer genomics, specifically relating to hematologic malignancies, as he has spent his career studying stem cell, T-cell, and leukemic genetics and biology. At Washington University, he holds the Lewis T. and Rosalind B. Apple Chair in Oncology, serves as chief of the Section of Stem Cell Biology in the Division of Oncology, and is Professor of Medicine and Genetics. Dr. Ley also serves as associate director of The Genome Institute (for Cancer Genomics) and directs the Embryonic Stem Cell Core at Washington University's Siteman Cancer Center.

In collaboration with Drs. Richard Wilson and Elaine Mardis at the Genome Institute at Washington University, Dr. Ley and colleagues were the first to sequence a cancer genome (from a patient with AML), and their investigations have provided important new insights into the origin and evolution of AML mutations. These findings have introduced a new, unbiased method for discovering cancer-initiated mutations in previously unidentified genes that may respond to targeted therapies. By highlighting the diversity of mutations in AML, Dr. Ley's breakthrough work in cancer genomics has demonstrated that most AML mutations are benign, background events that arise in hematopoietic stem cells as a function of aging, and that only a handful of mutations contribute to pathogenesis in each case.

Dr. Ley is also responsible for creating the first mouse model of acute promyelocytic leukemia (APL), a subtype of AML, and his group was the first to sequence a mouse cancer genome, using this model of leukemia. The model demonstrated that APL is caused by an initiating event that requires cooperating mutations to cause the disease, and it has provided key insights into the molecular mechanisms of this disorder in humans, since many of the cooperating mutations are conserved between species.

"The Society is honored to present this award to Dr. Ley for his many contributions to hematology and genetics, especially within the exciting field of genome sequencing," said ASH President Armand Keating, MD, of Princess Margaret Hospital in Toronto. "Through his identification of the genetics of leukemia development and relapse, Dr. Ley has discovered new pathways for targeted and individualized cancer therapies, which will help countless patients who suffer from blood cancers around the world."

Dr. Ley holds many prestigious awards and honors from ASH and other organizations. In addition to receiving the 2008 ASH Mentor Award in Basic Science and serving as a past chair of the ASH Committee on Scientific Affairs, Dr. Ley is the recipient of a National Institutes of Health (NIH) Merit Award. He currently serves as chair of NIH's National Human Genome Research Institute Board of Scientific Counselors and is also a past president of the American Society for Clinical Investigation, a fellow of the American Association for the Advancement of Science and the American Academy of Arts and Sciences, and a member of the Institute of Medicine.


'/>"/>
Contact: Claire Gwayi-Chore
cgwayi-chore@hematology.org
202-776-0544
American Society of Hematology
Source:Eurekalert

Related medicine news :

1. NIH awards $7.8 million for innovative HIV vaccine approaches
2. National Hartford Centers of Gerontological Nursing Excellence awards new fellows, scholars
3. ASTRO awards 5 research grants
4. State stem cell research funding agency awards $20 million to UCI, StemCells Inc.
5. Prevention of HIV spread focus of NIDAs 2012 Avant-Garde Awards
6. Klerman/Freedman Awards
7. Damon Runyon Cancer Research Foundation grants fellowship awards to 21 top young scientists
8. AOSSM presents annual research awards
9. U-Ms Taubman Institute awards inaugural $100,000 translational medical research prize
10. Standard Process Inc.’s Marketing Team Wins Six Awards
11. NIH awards $6.1 million grant to GUMC to establish Center of Excellence for Health Disparities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... QUEENS, N.Y (PRWEB) , ... October 13, 2017 , ... ... recently became a member of ElderCounsel, a national organization of elder law and special ... constantly changing laws and rules. It also provides a forum to network with elder ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... The Visiting ... Day Market. Featuring a collection of specialty vendors and unique items from across the ... and quality-focused health and wellness services offered by the VNA. The boutique will ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Yisrayl Hawkins, ... week that explains one of the most popular and least understood books in the ... cryptic and puzzling descriptions that have baffled scholars for centuries. Many have tossed it ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of a missionary ... Journey: From the Mountains to the Mission Field” is the creation of published author, ... ages and currently teaches a class of ladies at her church, which she has ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... treating sleep apnea using cutting-edge Oventus O2Vent technology. As many as ... disorder characterized by frequent cessation in breathing. Oral appliances can offer significant relief ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... for their devotion to personalized service, SMP Pharmacy Solutions announces ... the South Florida Business Journal,s 50 Fastest-Growing Companies, and listed ... national specialty pharmacy has found its niche.  To that end, ... honored by SFBJ as the 2017 Power Leader in Health ... his award in October, Bardisa said of the three achievements, ...
(Date:9/25/2017)... 2017   Montrium , an industry leader ... the IQPC Trial Master Files & Inspection Readiness ... EastHORN Clinical Services has selected eTMF Connect ... management. EastHORN, a leading European contract research organization ... transparency to enable greater collaboration with sponsors, improve ...
(Date:9/23/2017)... , Sept. 22, 2017 Janssen Biotech, Inc. ... response letter from the U.S. Food and Drug Administration ... of sirukumab for the treatment of moderately to severely ... additional clinical data are needed to further evaluate the ... severely active RA. ...
Breaking Medicine Technology: