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ASH awards Timothy J. Ley, M.D., with 2012 E. Donnall Thomas Lecture and Prize
Date:8/27/2012

Dr. Ley will present his lecture, "The AML Genome," at 9:00 a.m. on Monday, December 10, 2012, at the 54th ASH Annual Meeting and Exposition in Atlanta. His lecture will explore the use of whole genome sequencing in AML, which has offered an unprecedented view of the mutations that cause this disease. His lecture will also focus on next-generation DNA sequencing approaches in AML that are providing detailed information about the clonal architecture of AML at presentation and its evolution at relapse, as well as new clues regarding the genetic underpinnings of drug resistance and disease progression.

Dr. Ley has played a pivotal role in advancing the translational field of cancer genomics, specifically relating to hematologic malignancies, as he has spent his career studying stem cell, T-cell, and leukemic genetics and biology. At Washington University, he holds the Lewis T. and Rosalind B. Apple Chair in Oncology, serves as chief of the Section of Stem Cell Biology in the Division of Oncology, and is Professor of Medicine and Genetics. Dr. Ley also serves as associate director of The Genome Institute (for Cancer Genomics) and directs the Embryonic Stem Cell Core at Washington University's Siteman Cancer Center.

In collaboration with Drs. Richard Wilson and Elaine Mardis at the Genome Institute at Washington University, Dr. Ley and colleagues were the first to sequence a cancer genome (from a patient with AML), and their investigations have provided important new insights into the origin and evolution of AML mutations. These findings have introduced a new, unbiased method for discovering cancer-initiated mutations in previously unidentified genes that may respond to targeted therapies. By highlighting the diversity of mutations in AML, Dr. Ley's breakthrough work in cancer genomics has demonstrated that most AML mutations are benign, background events that arise in hematopoietic stem cells as a function of aging, and that only a handful of muta
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Contact: Claire Gwayi-Chore
cgwayi-chore@hematology.org
202-776-0544
American Society of Hematology
Source:Eurekalert

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