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ASCO to honor CHOP expert Garrett Brodeur with Pediatric Oncology Award and Lecture
Date:3/15/2013

select the most appropriate treatment.

Brodeur and his colleagues also identified deletions of important genes on chromosome 1 and on chromosome 11 as markers of high-risk neuroblastoma. He has collaborated with other CHOP researchers who identified the ALK gene as the gene responsible for most cases of hereditary neuroblastoma.

Another major focus of his research has concerned receptor tyrosine kinases, a family of signaling proteins that control the clinical behavior of neuroblastomas. His preclinical work led to a clinical trial with a novel drug that selectively blocks TRK signaling. He is now working on second-generation TRK inhibitors, as well as on nanoparticle delivery systems to treat patients more effectively, and with less toxicity.

Brodeur has been a member of the CHOP medical staff since 1993 and holds the Audrey E. Evans Endowed Chair in Pediatric Oncology at the Hospital. He also is a professor of Pediatrics in the Perelman School of Medicine at the University of Pennsylvania, where he is an associate director of the Abramson Cancer Center. Before arriving at CHOP, Brodeur did his fellowship in Pediatric Hematology-Oncology at St. Jude's Children's Research Center and a postdoctoral fellowship in Molecular Genetics at Washington University School of Medicine in St. Louis, where he remained until coming to CHOP.


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Contact: Rachel Salis-Silverman
salis@email.chop.edu
267-426-6063
Children's Hospital of Philadelphia
Source:Eurekalert  

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ASCO to honor CHOP expert Garrett Brodeur with Pediatric Oncology Award and Lecture
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