Navigation Links
ASCO to honor CHOP expert Garrett Brodeur with Pediatric Oncology Award and Lecture
Date:3/15/2013

The American Society of Clinical Oncology (ASCO) today announced it will confer one of its highest awards on pediatric oncologist Garrett M. Brodeur, M.D., of the Cancer Center at The Children's Hospital of Philadelphia. Brodeur will receive the Pediatric Oncology Award and deliver the Pediatric Oncology Lecture on Friday, May 31 during the ASCO annual meeting in Chicago.

The Award and Lecture recognize "outstanding scientific work of major importance to the field of pediatric oncology" during the course of a career. Brodeur is an expert in neuroblastoma, the most common solid tumor of childhood.

A cancer of the peripheral nervous system that typically appears as a tumor in a child's abdomen or chest, neuroblastoma varies greatly in severity, ranging from forms that spontaneously disappear to high-risk subtypes that are difficult to cure. Because of this variability, researchers have sought ways to predict the course of disease in order to select the most appropriate treatment for each patient. The underlying assumption of this approach is that better understanding of the biology of this cancer will allow pediatric oncologists to avoid undertreating or overtreating a child.

Over his career, Brodeur has focused on identifying the genes, proteins and biological pathways that give rise to neuroblastoma and drive its clinical behavior. He also has built on this knowledge to develop more effective and less toxic treatments for children by targeting specific pathways.

His research first demonstrated in the 1980s that when neuroblastoma cells developed multiple copies of the MYCN gene, a process called amplification, a high-risk subtype of neuroblastoma occurs, necessitating more aggressive treatment. This discovery ushered in the current era of genomic analysis of tumors, both in adult and pediatric oncology. Profiling specific molecular alterations in a given patient's tumor helps oncologists to predict that patient's outcome and select the most appropriate treatment.

Brodeur and his colleagues also identified deletions of important genes on chromosome 1 and on chromosome 11 as markers of high-risk neuroblastoma. He has collaborated with other CHOP researchers who identified the ALK gene as the gene responsible for most cases of hereditary neuroblastoma.

Another major focus of his research has concerned receptor tyrosine kinases, a family of signaling proteins that control the clinical behavior of neuroblastomas. His preclinical work led to a clinical trial with a novel drug that selectively blocks TRK signaling. He is now working on second-generation TRK inhibitors, as well as on nanoparticle delivery systems to treat patients more effectively, and with less toxicity.

Brodeur has been a member of the CHOP medical staff since 1993 and holds the Audrey E. Evans Endowed Chair in Pediatric Oncology at the Hospital. He also is a professor of Pediatrics in the Perelman School of Medicine at the University of Pennsylvania, where he is an associate director of the Abramson Cancer Center. Before arriving at CHOP, Brodeur did his fellowship in Pediatric Hematology-Oncology at St. Jude's Children's Research Center and a postdoctoral fellowship in Molecular Genetics at Washington University School of Medicine in St. Louis, where he remained until coming to CHOP.


'/>"/>

Contact: Rachel Salis-Silverman
salis@email.chop.edu
267-426-6063
Children's Hospital of Philadelphia
Source:Eurekalert  

Related medicine news :

1. LA BioMed physician-researchers honored as top doctors
2. “Real Housewives of Beverly Hills” Star Yolanda Foster, Mark Eshoo, and Dr. Steven Schutzer to be Honored at Lyme Research Alliance's Gala on April 6, 2013
3. Bob Turk to be Honored as Communicator of the Year at Local Gala, Hosted by The Hearing and Speech Agency
4. Fitness Revolution Honored as Top Fitness Franchise in Franchise Business Review’s Franchisee Satisfaction Awards
5. Dr. Howard Koh to receive highest honor from Society for Public Health Education
6. Sixty HealthLine Systems, Inc. Clients Honored as Healthgrades 2013 Distinguished Hospitals for Clinical Excellence
7. Bhatia honored by Southern Society for Pediatric Research
8. HeartView Global Foundation honors World-Renowned Cardiologist, Asher Kimchi and Philanthropist Diane Brinson
9. Multiple Elsevier nursing titles honored by the American Journal of Nursing
10. Society of Toxicology honors members for scientific achievements
11. The Association for Gerontology in Higher Education honors new officers, fellows, awardees
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
ASCO to honor CHOP expert Garrett Brodeur with Pediatric Oncology Award and Lecture
(Date:2/24/2017)... MN (PRWEB) , ... February 24, 2017 , ... ... of its newly designed TaskMate Go. Core benefits and advantages built into the ... and a stylish, functional look and feel. Ability to gain the benefits embedded ...
(Date:2/24/2017)... ... 24, 2017 , ... Only two months after the official release of The ... Cannes (France), XO Private has initiated a second print-run of its lavish luxury travel ... metre across when open, weighs in at more than six kilos, retails at EUR ...
(Date:2/24/2017)... ... , ... An in-depth computational analysis of genetic variants implicated in both schizophrenia ... that may explain why susceptibility to one of the disorders could place individuals at ... in the journal npj Schizophrenia. , “There is a wealth of genomic data ...
(Date:2/24/2017)... ... ... Smart Machine Age is here, and it’s disrupting everything. Not only could it drive ... United States may be taken over by technology in the next five to fifteen ... colleagues is drawing to a close. Success will belong to those who can quiet ...
(Date:2/24/2017)... ... February 24, 2017 , ... With millions of Americans ... important that we all are aware of our options and are empowered with ... announce the launch of its newest edition of "Vision and Hearing" in USA ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... NEW YORK , February 27, 2017 ... (PII) celebrates the pharmaceutical companies that are most successful at ... ... question: if you gave the same molecule to two different ... it? Based on systematic, objective analysis of each ...
(Date:2/27/2017)... Leading Countries, Technologies and Companies The ... a CAGR of 8.9% from 2016-2021 and CAGR of 9.2% from ... 9.1% from 2016 to 2027. The market is estimated at $816m ... ... on to discover how you can exploit the future business opportunities ...
(Date:2/27/2017)... and PETACH TIKVAH, Israel , ... (NASDAQ: BCLI), a leading developer of adult stem cell ... June S. Almenoff , M.D., Ph.D., FACP, and ... Board of Directors.  "Dr. Almenoff and ... appointments come at an exciting time for our company," ...
Breaking Medicine Technology: