Navigation Links
ASCO to honor CHOP expert Garrett Brodeur with Pediatric Oncology Award and Lecture
Date:3/15/2013

The American Society of Clinical Oncology (ASCO) today announced it will confer one of its highest awards on pediatric oncologist Garrett M. Brodeur, M.D., of the Cancer Center at The Children's Hospital of Philadelphia. Brodeur will receive the Pediatric Oncology Award and deliver the Pediatric Oncology Lecture on Friday, May 31 during the ASCO annual meeting in Chicago.

The Award and Lecture recognize "outstanding scientific work of major importance to the field of pediatric oncology" during the course of a career. Brodeur is an expert in neuroblastoma, the most common solid tumor of childhood.

A cancer of the peripheral nervous system that typically appears as a tumor in a child's abdomen or chest, neuroblastoma varies greatly in severity, ranging from forms that spontaneously disappear to high-risk subtypes that are difficult to cure. Because of this variability, researchers have sought ways to predict the course of disease in order to select the most appropriate treatment for each patient. The underlying assumption of this approach is that better understanding of the biology of this cancer will allow pediatric oncologists to avoid undertreating or overtreating a child.

Over his career, Brodeur has focused on identifying the genes, proteins and biological pathways that give rise to neuroblastoma and drive its clinical behavior. He also has built on this knowledge to develop more effective and less toxic treatments for children by targeting specific pathways.

His research first demonstrated in the 1980s that when neuroblastoma cells developed multiple copies of the MYCN gene, a process called amplification, a high-risk subtype of neuroblastoma occurs, necessitating more aggressive treatment. This discovery ushered in the current era of genomic analysis of tumors, both in adult and pediatric oncology. Profiling specific molecular alterations in a given patient's tumor helps oncologists to predict that patient's outcome and select the most appropriate treatment.

Brodeur and his colleagues also identified deletions of important genes on chromosome 1 and on chromosome 11 as markers of high-risk neuroblastoma. He has collaborated with other CHOP researchers who identified the ALK gene as the gene responsible for most cases of hereditary neuroblastoma.

Another major focus of his research has concerned receptor tyrosine kinases, a family of signaling proteins that control the clinical behavior of neuroblastomas. His preclinical work led to a clinical trial with a novel drug that selectively blocks TRK signaling. He is now working on second-generation TRK inhibitors, as well as on nanoparticle delivery systems to treat patients more effectively, and with less toxicity.

Brodeur has been a member of the CHOP medical staff since 1993 and holds the Audrey E. Evans Endowed Chair in Pediatric Oncology at the Hospital. He also is a professor of Pediatrics in the Perelman School of Medicine at the University of Pennsylvania, where he is an associate director of the Abramson Cancer Center. Before arriving at CHOP, Brodeur did his fellowship in Pediatric Hematology-Oncology at St. Jude's Children's Research Center and a postdoctoral fellowship in Molecular Genetics at Washington University School of Medicine in St. Louis, where he remained until coming to CHOP.


'/>"/>

Contact: Rachel Salis-Silverman
salis@email.chop.edu
267-426-6063
Children's Hospital of Philadelphia
Source:Eurekalert  

Related medicine news :

1. LA BioMed physician-researchers honored as top doctors
2. “Real Housewives of Beverly Hills” Star Yolanda Foster, Mark Eshoo, and Dr. Steven Schutzer to be Honored at Lyme Research Alliance's Gala on April 6, 2013
3. Bob Turk to be Honored as Communicator of the Year at Local Gala, Hosted by The Hearing and Speech Agency
4. Fitness Revolution Honored as Top Fitness Franchise in Franchise Business Review’s Franchisee Satisfaction Awards
5. Dr. Howard Koh to receive highest honor from Society for Public Health Education
6. Sixty HealthLine Systems, Inc. Clients Honored as Healthgrades 2013 Distinguished Hospitals for Clinical Excellence
7. Bhatia honored by Southern Society for Pediatric Research
8. HeartView Global Foundation honors World-Renowned Cardiologist, Asher Kimchi and Philanthropist Diane Brinson
9. Multiple Elsevier nursing titles honored by the American Journal of Nursing
10. Society of Toxicology honors members for scientific achievements
11. The Association for Gerontology in Higher Education honors new officers, fellows, awardees
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
ASCO to honor CHOP expert Garrett Brodeur with Pediatric Oncology Award and Lecture
(Date:4/28/2017)... ... ... The Radiology Business Management Association (RBMA) is pleased to announce ... process has been in place since the RBMA was founded in 1968 with all ... Jim Hamilton, MHA, CMM, FRBMA, as president. Dr. Dickerson the chief executive officer for ...
(Date:4/28/2017)... ... April 28, 2017 , ... ... and College of Urgent Care Medicine will host industry leaders for the annual ... will help those in the industry adapt to the issues currently affecting urgent ...
(Date:4/28/2017)... ... , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh in Abilene, Texas, has ... which He does not. Yisrayl says with so many titles and names for the ... he says with a little Scripture, backed with a lot of research, the truth is ...
(Date:4/28/2017)... (PRWEB) , ... April 28, 2017 , ... ... skincare and advanced nutraceutical supplements, through its Nova Skin Sciences division, recently ... hydrating benefits of a moisturizer with the power of an anti-aging concentrate. ...
(Date:4/28/2017)... ... 2017 , ... Christie Medical Holdings, Inc. , with its market-leading ... Medical Inc. , a leader in infusion therapy and pain management. , Intravenous ... percent of hospital patients receiving a peripheral IV catheter as part of their treatment ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... , Tenn. and DALLAS , April 19, ... Inc., announced that the first patients in ... EndoStim device in the Lower Esophageal Sphincter Stimulation for ... minimally-invasive implantable device designed to provide long-term reflux control ... GERD affects nearly 65 million people in ...
(Date:4/19/2017)... , April 19, 2017  Novartis today announced ... National Heart, Lung, and Blood Institute (NHLBI) of ... 58% of patients with treatment-naïve severe aplastic anemia ... treated with eltrombopag at the initiation of and ... study evaluated three sequential treatment groups, or cohorts. ...
(Date:4/18/2017)... 18, 2017 Research and Markets has announced ... report to their offering. ... global arthroscopy devices market to grow at a CAGR of 6.35% ... Devices Market 2017-2021, has been prepared based on an in-depth market ... landscape and its growth prospects over the coming years. The report ...
Breaking Medicine Technology: