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ASCO data highlight novel anti-cancer approach that exposes tumors to immune attack
Date:5/20/2010

TUSTIN, Calif., May 20, 2010 -- Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM), a clinical-stage biopharmaceutical company developing innovative monoclonal antibodies for the treatment of cancer and viral infections, will present data from three Phase II clinical trials highlighting the clinical potential of its unique phosphatidylserine (PS)-targeting antibody bavituximab for the treatment of solid tumors. PS-targeting antibodies represent an entirely new approach to treating cancer, using a novel immunomodulatory mechanism that enables the patient's own immune system to attack and destroy the tumor. Phase II data on the company's lead PS-targeting antibody bavituximab administered in combination with chemotherapy will be presented at the 2010 ASCO Annual Meeting.

"PS is a highly immunosuppressive molecule that inactivates the immune system and allows tumors to evade detection," commented Dr. Philip Thorpe, professor of pharmacology at the University of Texas Southwestern Medical Center, a scientific advisor to Peregrine and a pioneer in the development of PS-targeting therapies. "Supported by a growing body of research, PS-targeting antibodies appear to play a critical role in blocking this immunosuppressive molecule and reactivating the immune system's ability to mount a robust anti-tumor response. Since chemotherapy increases the exposure of PS on tumor blood vessels, bavituximab has even more of this immunosuppressive molecule to target, potentially offering a new synergistic approach for the treatment of cancer."

Based on the positive data reported to date, Peregrine plans to initiate a new randomized, placebo-controlled, double-blinded Phase II trial of bavituximab in combination with chemotherapy in refractory non-small cell lung cancer (NSCLC) patients. A new Phase II trial in front-line NSCLC patients is also expected to begin in by mid-year.

Reactivating the Immune System by Blocking "Flipped" Phospholipids


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Contact: Barbara Lindheim
blindheim@biocompartners.com
212-918-4650
BioCom Partners
Source:Eurekalert

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