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ARCA Discovery Changes Name to ARCA biopharma to Reflect Focus on Drug Commercialization
Date:3/28/2008

s to market bucindolol, for which it owns exclusive worldwide rights, in the U.S. through its own sales force.

Bucindolol is a next-generation beta-blocker and vasodilator that could become the first personalized, genetically-targeted cardiovascular therapy, based on substantial Phase 3 data showing that physicians could determine whether bucindolol is the right therapy for a patient with a simple genetic test.

Landmark research published in the Proceedings of the National Academies of Sciences in 2006 demonstrated that bucindolol can reduce mortality in HF patients when used as a genetically-targeted treatment. More recently, the company presented data at last November's American Heart Association annual meeting, which showed that treatment with bucindolol also helped to prevent atrial fibrillation and life threatening ventricular arrhythmia.

ARCA developed bucindolol by leveraging its proprietary technology platform combining expertise in cardiovascular pathophysiology, molecular genetics and clinical development, in a unique approach that enables the efficient identification of pharmacogenetic targets. ARCA's earlier research identified pathways affecting bucindolol response that are modulated by common genetic variations.

About ARCA biopharma, Inc.

ARCA biopharma, Inc. is a privately-held company based in Denver, Colorado focused on developing and commercializing genetically-targeted therapies for heart failure and other cardiovascular diseases. The Company recently closed a Series B round of $18 million, led by new investors Skyline Ventures and InterWest Partners. ARCA completed a $15 million Series A round in 2006 led by Atlas Venture and Boulder Ventures, which also participated in the Series B round. For more information please visit http://www.arcabiopharma.com.


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SOURCE ARCA Discovery, Inc.
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