Postoperative cognitive dysfunction is associated with neuronal apoptosis, which may result from post-surgery inflammation, the phosphorylation of tau protein and the accumulation of amyloid in aged people. 5′adenosine monophosphate-activated protein kinase (AMPK) can be involved in anti-inflammation, neuronal repair and anti-inflammation of the body through different downstream proteins and pathways. In addition, the activation of AMPK regulates tau protein phosphorylation and reduces amyloidogenesis in neurons. Yanlin Bi and co-workers from the Affiliated Qianfoshan Hospital of Shandong University in China found that inflammatory cytokines and AMPK changed remarkably in the hippocampus of postoperative cognitive dysfunction rats. Therefore, the involvement of AMPK and inflammatory factors in postoperative cognitive dysfunction is considered to be an accommodation to postoperative cognitive dysfunction. The relevant study has been published in the Neural Regeneration Research (Vol. 9, No. 5, 2014).
|Contact: Meng Zhao|
Neural Regeneration Research