Navigation Links
AMD risk on the rise for Asians; retinal vein 'bypass' may help many CRVO patients
Date:5/1/2010

SAN FRANCISCO, CAThe May issue of Ophthalmology, the journal of the American Academy of Ophthalmology, includes a surprising, first report on increasing rates of age-related macular degeneration (AMD) among Asians, and describes an innovative "bypass" laser surgery that may help many people with central retinal vein occlusion (CRVO) avoid serious vision loss.

Are Asians as Vulnerable to AMD as Caucasians?

A major review by Tien Yi Wong, MD, MPH, PhD, and Singapore Eye Research Institute colleagues concludes that Asians may be just as susceptible to age-related macular degeneration as Caucasians. Asians have long been considered a low risk group for AMD, which is a leading cause of vision loss in older Caucasians. Since the number of elderly people is increasing in Asia, Dr. Wong's study suggests that health systems there need to prepare for an onslaught of AMD.

Pooling results from nine standardized-diagnosis studies in five Asian populations (Japan, China, South Korea, India and Singapore), Dr. Wong's group confirmed prevalence of early-stage AMD as 6.8 percent and late-stage as 0.56 percent, comparable to Caucasians at 8.8 percent and 0.59 percent, respectively. All rates pertain to people aged 40 to 79 years. Also, among those with late AMD, the "wet" (neovascular) form appeared to be more prevalent in Asians than in whites. Asian men were more likely to develop late AMD than white men and much more likely than Asian women.

The researchers speculate that Asian men may be more susceptible to polypoidal choroidal vasculopathy (PCV), abnormal development of blood vessels in the deeper layers of the eye. Whether PCV is a sub-type of AMD or a separate disorder remains controversial; it is also unclear whether PCV responds well to medications that inhibit abnormal blood vessel growth (anti-vascular endothelial growth factor drugs such as Avastin and Lucentis) that help many wet AMD patients keep their vision.

"Future studies should evaluate whether there are 'Asian forms' of AMD and discern other racial/ethnic differences in Asian susceptibility," Dr. Wong said."Our meta-analysis could not adjust for important risk factors like smoking, common among many Asian men; nor did this study include all relevant Asian racial/ethnic groups," he added.

"Bypass" May Lead to Vision Gains for CRVO Patients

Central retinal vein occlusion (CRVO) affects one to four percent of Americans older than 40 and very often causes severe vision loss, including "legal blindness" (20/200 vision). While current treatments reduce CRVO symptoms such as macular edemaswelling of the center of the eye's light-sensitive retinanone address the underlying problem, the blocked retinal vein. Ian L. McAllister, MD, Lions Eye Institute, Australia, and his research team took direct aim at the problem, using lasers to create a "bypass" around the constricted retinal vein with the aim of restoring near-normal blood flow to the retina.

In three-quarters of the eyes treated the "bypass" was successful, and patients achieved significant vision gains by the 18 month follow-up. This study was also the first prospective, randomized trial to compare the bypass approach, called laser-induced chorioretinal venous anastomosis (L-CRA), with conventional treatment.

L-CRAs were successfully created in 76.4 percent of the 58 patients in whom the procedure was attempted. Overall, bypass-treated patients achieved significantly better visual acuity and were more likely to gain 20/40 vision (the legal standard for drivers in many countries) than were control group patients. Bypass patients were significantly less likely to have moderate or severe vision loss. While about 18 percent of L-CRA-treated patients developed a significant complicationabnormal blood vessel growth at the surgery sitethe researchers report that due to close monitoring and effective management, negative consequences from this and other complications were minimal.

"The risk of complications from L-CRA should be weighed against the substantial vision loss faced by CRVO patients with standard treatments," Dr. McAllister said. "In future studies of L-CRA, optical coherence tomography (not widely available when our study began) would be another useful outcome measure for L-CRA effectiveness," he added.


'/>"/>

Contact: Mary Wade
mwade@aao.org
415-447-0221
American Academy of Ophthalmology
Source:Eurekalert

Related medicine news :

1. Researchers find new insights into inherited retinal disease
2. Pluromed Announces Completion of Enrollment in LeGoo™ Cardiac Bypass Clinical Trial
3. Bypass procedure used during infant heart surgery does not impair later neurological outcomes
4. Special Bypass Procedure Used During Infant Heart Surgery Does Not Impair Later Neurological Outcomes in Children
5. For Very Obese, Gastric Bypass May Extend Life
6. New method to grow arteries could lead to biological bypass for heart disease
7. Gastric bypass surgery increases risk of kidney stones
8. Dr. Feiz (drfeiz.com) Asks: What Is Better for You? Lap Band Surgery/Realize Band Surgery or Gastric Bypass Surgery
9. EXCEL trial will determine safety and efficacy of drug-eluting stents vs. bypass surgery
10. Newer Blood Thinner Beats Plavix for Bypass Patients
11. UCLA study compares bypass surgery to angioplasty
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... ... , ... The temporary closing of Bruton Memorial Library on June 21 due to a possible ... often overlooked aspect of head lice: the parasite’s ability to live away from a human ... but a necessary one in the event that lice have simply gotten out of control. ...
(Date:6/25/2016)... ... , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors ... Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green ... hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train ...
(Date:6/25/2016)... ... ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter of ... too high can result in disappointment, perhaps even self-loathing. However, those who set the ... Research from PsychTests.com reveals that behind the tendency to set low expectations ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016 The Academy of Managed Care ... that would allow biopharmaceutical companies to more easily ... make formulary and coverage decisions, a move that addresses ... medicines. The recommendations address restrictions in the ... the drug label, a prohibition that hinders decision makers ...
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... "The World Market for Companion Diagnostic Tests" report to ... World Market for Companion Diagnostics The World ... diagnostic and personalized medicine diagnostics. Market analysis in the report ... Diagnostics Test Market (In Vitro Diagnostic Kits) by Region (N. ...
(Date:6/24/2016)... , Belgium , June 24, ... VNRX), today announced the appointment of Dr. ... Directors as a Non-Executive Director, effective June 23, ... Audit, Compensation and Nominations and Governance Committees.  As ... Futcher will provide independent expertise and strategic counsel ...
Breaking Medicine Technology: