Navigation Links
AMD discovery: New hope for treatment of vision loss
Date:2/20/2008

This release is available in French.

Montreal, February 20, 2008 Scientists have won a major battle in the fight against age-related macular degeneration, or AMD, a blinding eye disease that affects millions of people. An international team, led by researchers at Sainte-Justine Hospital and the Universit de Montral, has identified the deficient receptor that causes the dry form of AMD.

In the February edition of the medical journal PLoS Medicine, the researchers explain how a deficiency of the CD36 receptor prevents the evacuation of oxidized lipids in the eye. Those oxidized lipids in turn accumulate and attack the layers beneath and over the retina thereby causing vision loss.

Our discovery has important implications for the development of new therapies, explains lead researcher, Dr. Sylvain Chemtob, who co-authored the paper with Universit de Montral collaborator Dr. Huy Ong, a professor at the Faculty of Pharmacy, as well as Florian Sennlaub of the Institut national de la sant et de la recherche mdicale (INSERM) in France.

Chemtob, a neonatal researcher at Sainte-Justine Hospital and a professor at the Universit de Montrals Department of Pediatrics and School of Optometry, used mice and rat models to pinpoint the scavenger receptor responsible for retinal degeneration typical of dry AMD. We found that a deficiency in CD36 receptors leads to significant and progressive age-related macular degeneration, he says. CD36 deficiency leads to central vision loss a key feature of dry AMD.

This discovery brings us one step closer to treating dry AMD, which could significantly improve the quality of life of seniors who are most affected by this eye disease, added co-author Dr. Huy Ong. Now that we have also developed the molecules that activate CD 36 receptor, we are working on the validation of the efficacy of these molecules as potential therapeutic agents for dry AMD treatment with prospect at the horizon of 2015.

Wet and dry AMD remain an alarming cause of vision loss in the western world, which according to the AMD Alliance International, affect 30 million people aged 50 and over. Dry AMD is the most pervasive of the disorders and affects 90 percent of AMD cases.


'/>"/>

Contact: Sylvain-Jacques Desjardins
sylvain-jacques.desjardins@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Related medicine news :

1. In Combination With FOLFOX4, the Effect of Erbitux and Avastin On Survival Rates Will Drive Prescription Decisions in the Treatment of Stage III Colon Cancer
2. Varian Medical Systems Announces Symposia on RapidArc Technology for Faster, More Precise Radiotherapy Treatments
3. No Difference Found in Treatments for Acute Kidney Failure
4. Missing Chromosome Improves Response to Brain Tumor Treatment
5. Combo Treatment Best for Melanoma, Advanced Ovarian Cancer
6. Yes, no, maybe so: New model helps identify what works in mental health treatment
7. USAID Awards $70 Million for the Prevention and Treatment of Obstetric Fistula
8. AIDS Healthcare Foundation and NCHADS Partnership Adds 8th Cambodian AIDS Treatment Center in Kirivong
9. Many Prostate Cancers Will Not Need Treatment
10. High-End Treatment Center Moonview Sanctuary Unveils Four New Core Treatment Programs
11. Respiratory Distress Treatment Studies Conflict
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... Santa Rosa, California (PRWEB) , ... January 24, 2017 , ... ... named Cary McNamara as chief financial officer. , “Cary’s broad financial ... individual who possesses both the strategic planning and day-to-day financial operations skills we need ...
(Date:1/24/2017)... ... January 24, 2017 , ... The Cruise Web ... as part of the line’s 4th Annual MSC True Partnerships’ Awards. , ... American travel partners for the year based on overall business growth in revenue and ...
(Date:1/24/2017)... Baltimore, MD (PRWEB) , ... January 24, 2017 ... ... applicants to advance to the semi-final round of the 2017 Cupid's Cup Entrepreneurship ... competition celebrates its 12th year in 2017. The entrepreneurs will showcase their businesses ...
(Date:1/24/2017)... ... January 24, 2017 , ... West’s Health ... annual Solutions Series of webinars will start January 31 with a session about ... of current health and benefits topics, including employee engagement, pricing transparency, population health ...
(Date:1/24/2017)... ... , ... His message has been heard by more than 100,000 students and ... , Joel Feldman, has reached his biggest national audience yet: the three million daily ... newspapers in circulation in the country, and he hopes it will help spread his ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... SEATTLE , Jan. 24, 2017  CTI BioPharma ... that Michael A. Metzger has been appointed ... experience leading and growing companies in the biopharmaceutical industry ... pleased to welcome Michael to the Board of CTI ... CEO of CTI BioPharma. "Michael is an accomplished leader ...
(Date:1/24/2017)... 24, 2017 When tragedy strikes, victims often can,t communicate, ... conditions they have, and who back home is wondering about them. ... informed about the safety of their family and friends, while helping ... in times of crisis. ... If you find yourself or your family in one of ...
(Date:1/24/2017)... 24, 2017 Trifecta Clinical , a ... appointing Rick Ward to Vice President of ... is also announcing the promotion of Ericka Atkinson ... Rick joins Trifecta from Greenphire where he ... senior business development positions within the healthcare industry throughout ...
Breaking Medicine Technology: