This release is available in French.
Montreal, February 20, 2008 Scientists have won a major battle in the fight against age-related macular degeneration, or AMD, a blinding eye disease that affects millions of people. An international team, led by researchers at Sainte-Justine Hospital and the Universit de Montral, has identified the deficient receptor that causes the dry form of AMD.
In the February edition of the medical journal PLoS Medicine, the researchers explain how a deficiency of the CD36 receptor prevents the evacuation of oxidized lipids in the eye. Those oxidized lipids in turn accumulate and attack the layers beneath and over the retina thereby causing vision loss.
Our discovery has important implications for the development of new therapies, explains lead researcher, Dr. Sylvain Chemtob, who co-authored the paper with Universit de Montral collaborator Dr. Huy Ong, a professor at the Faculty of Pharmacy, as well as Florian Sennlaub of the Institut national de la sant et de la recherche mdicale (INSERM) in France.
Chemtob, a neonatal researcher at Sainte-Justine Hospital and a professor at the Universit de Montrals Department of Pediatrics and School of Optometry, used mice and rat models to pinpoint the scavenger receptor responsible for retinal degeneration typical of dry AMD. We found that a deficiency in CD36 receptors leads to significant and progressive age-related macular degeneration, he says. CD36 deficiency leads to central vision loss a key feature of dry AMD.
This discovery brings us one step closer to treating dry AMD, which could significantly improve the quality of life of seniors who are most affected by this eye disease, added co-author Dr. Huy Ong. Now that we have also developed the molecules that activate CD 36 receptor, we are working on the validation of the efficacy of these molecules as potential therapeutic agents for dry AMD treatment with pros
|Contact: Sylvain-Jacques Desjardins|
University of Montreal