Navigation Links
AMD discovery: New hope for treatment of vision loss
Date:2/20/2008

This release is available in French.

Montreal, February 20, 2008 Scientists have won a major battle in the fight against age-related macular degeneration, or AMD, a blinding eye disease that affects millions of people. An international team, led by researchers at Sainte-Justine Hospital and the Universit de Montral, has identified the deficient receptor that causes the dry form of AMD.

In the February edition of the medical journal PLoS Medicine, the researchers explain how a deficiency of the CD36 receptor prevents the evacuation of oxidized lipids in the eye. Those oxidized lipids in turn accumulate and attack the layers beneath and over the retina thereby causing vision loss.

Our discovery has important implications for the development of new therapies, explains lead researcher, Dr. Sylvain Chemtob, who co-authored the paper with Universit de Montral collaborator Dr. Huy Ong, a professor at the Faculty of Pharmacy, as well as Florian Sennlaub of the Institut national de la sant et de la recherche mdicale (INSERM) in France.

Chemtob, a neonatal researcher at Sainte-Justine Hospital and a professor at the Universit de Montrals Department of Pediatrics and School of Optometry, used mice and rat models to pinpoint the scavenger receptor responsible for retinal degeneration typical of dry AMD. We found that a deficiency in CD36 receptors leads to significant and progressive age-related macular degeneration, he says. CD36 deficiency leads to central vision loss a key feature of dry AMD.

This discovery brings us one step closer to treating dry AMD, which could significantly improve the quality of life of seniors who are most affected by this eye disease, added co-author Dr. Huy Ong. Now that we have also developed the molecules that activate CD 36 receptor, we are working on the validation of the efficacy of these molecules as potential therapeutic agents for dry AMD treatment with pros
'/>"/>

Contact: Sylvain-Jacques Desjardins
sylvain-jacques.desjardins@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Page: 1 2

Related medicine news :

1. In Combination With FOLFOX4, the Effect of Erbitux and Avastin On Survival Rates Will Drive Prescription Decisions in the Treatment of Stage III Colon Cancer
2. Varian Medical Systems Announces Symposia on RapidArc Technology for Faster, More Precise Radiotherapy Treatments
3. No Difference Found in Treatments for Acute Kidney Failure
4. Missing Chromosome Improves Response to Brain Tumor Treatment
5. Combo Treatment Best for Melanoma, Advanced Ovarian Cancer
6. Yes, no, maybe so: New model helps identify what works in mental health treatment
7. USAID Awards $70 Million for the Prevention and Treatment of Obstetric Fistula
8. AIDS Healthcare Foundation and NCHADS Partnership Adds 8th Cambodian AIDS Treatment Center in Kirivong
9. Many Prostate Cancers Will Not Need Treatment
10. High-End Treatment Center Moonview Sanctuary Unveils Four New Core Treatment Programs
11. Respiratory Distress Treatment Studies Conflict
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... 28, 2014 Gurnick Academy of Medical ... program is re-accredited for the 5 years of the ... Technologists (ARMRIT). , “We are very proud to ... our program to make sure we provide the best ... interest in MRI field nowadays and I look forward ...
(Date:8/28/2014)... A chronic problem in winemaking is "stuck fermentation," when ... alcohol and carbon dioxide prematurely shuts down, leaving the ... can spoil the wine. , A team of researchers ... a biochemical communication system behind this problem. Working ... can reproduce itself -- the system enables bacteria in ...
(Date:8/28/2014)... of Medicine published research results on Aug. 21 ... safely reduce the viral load and clinical illness of ... (RSV). , Le Bonheur Children,s Hospital and ... Disease Specialist John DeVincenzo, MD, is lead author of ... common cause of lower respiratory tract infections in young ...
(Date:8/28/2014)... smoking kills approximately 440,000 Americans each year, according ... It,s the leading cause of preventable death worldwide. ... resort to nicotine replacement therapies. , A ... University of Miami (UM) suggest that small dosages ... harmful to human musculoskeletal system, due to overuse. ...
(Date:8/28/2014)... Lifesmart (formerly Source Network Sales and ... saunas, spas and hot tubs, today unveiled its entry ... purifiers, and price point multi-function tower fans. , “These ... established product lines and they will help us even ... less dependent on fourth quarter weather trends. Additionally ...
Breaking Medicine News(10 mins):Health News:Gurnick Academy’s MRI Program Is Re-Accredited by ARMRIT for the 5 Years 2Health News:Prions can trigger 'stuck' wine fermentations, researchers find 2Health News:DeVincenzo study breakthrough in RSV research 2Health News:Are cigarette substitutes a safe alternative? It depends on user habits 2Health News:Are cigarette substitutes a safe alternative? It depends on user habits 3Health News:Lifesmart Unveils New Line of Air Conditioners, Dehumidifiers, Humidifiers, Air Purifiers and Price Point Multi-Function Tower Fans Expanding the lifesmart zone Brand 2
... By Amanda Gardner HealthDay Reporter , TUESDAY, April ... take calcium supplements to prevent bone deterioration may, in fact, be ... previous studies with similar findings, the new conclusions don,t necessarily mark ... study released online April 19 in the BMJ . ...
... at the University of Pennsylvania School of Medicine are delving ... of chromosomes. Recent work, e-published in Nature Structural & ... telomeres, can be protected by caps made up of specialized ... Telomere caps are like a knot at the end of ...
... major discovery about an enzyme,s structure has opened a window ... have determined the structure of a nuclease that will help ... for cancer research. DNA repair pathways are very important ... tools the cell uses to do those repairs are not ...
... that will test whether heart disease drugs can be used ... class of drugs - known as statins - can prevent ... cent of pregnant women in the UK. The ... research showing that statins, which are prescribed to lower heart ...
... HealthDay Reporter , TUESDAY, April 19 (HealthDay News) -- ... to curb misuse of extended-release and long-acting opioid pain killers ... Risk Evaluation and Mitigation Strategy (REMS) is part of a ... reduce overall prescription drug abuse in the United States. ...
... The European College of Neuropsychopharmacology (ECNP) is pleased ... the 2011 ECNP Neuropsychopharmacology Award in Basic Science ... the brain adenosine system. The ECNP Neuropsychopharmacology Award ... neuropsychopharmacology and closely related disciplines. The award is ...
Cached Medicine News:Health News:Women Taking Calcium Supplements May Risk Heart Health, Researchers Say 2Health News:Women Taking Calcium Supplements May Risk Heart Health, Researchers Say 3Health News:Ends of chromosomes protected by stacked, coiled DNA caps 2Health News:Ends of chromosomes protected by stacked, coiled DNA caps 3Health News:Nature's elegant solution to repairing DNA in cancer, other conditions 2Health News:Heart drugs could cut blood pressure risks in pregnancy 2Health News:FDA Looks to Crack Down on Misuse of Opioid Painkillers 2Health News:Bertil Fredholm wins the 2011 ECNP Neuropsychopharmacology Award in basic science research 2
(Date:8/28/2014)... 28, 2014  Seres Health, a clinical-stage therapeutics ... the human microbiome, announced today that Dr. ... R&D and Chief Scientific Officer, will be presenting ... and Chemotherapy (ICAAC). The presentation will highlight the ... mixture of bacterial spores derived from the human ...
(Date:8/28/2014)... , Aug. 28, 2014 /PRNewswire-iReach/ -- Gateway ... at the 9 th Annual Global Pharma ... , September 8-9 th . The Global Pharma ... leaders in small molecule and biologic pharmaceutical manufacturing. ... challenges that today,s manufacturers face, such as the ...
(Date:8/28/2014)... 28, 2014 Reportlinker.com announces ... is available in its catalogue: ... Markets to 2020 - Novel Therapeutic ... Newly Diagnosed and Recurrent GBM ... Glioblastoma Multiforme Therapeutics in ...
Breaking Medicine Technology:Seres Health to Present Clinical Findings at ICAAC 2014 Conference 2Gateway Analytical to Promote Particulate Identification Services at the 9th Annual Global Pharma Manufacturing Summit 2Gateway Analytical to Promote Particulate Identification Services at the 9th Annual Global Pharma Manufacturing Summit 3Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 2Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 3Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 4Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 5Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 6Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 7Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 8Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 9
... HAYWARD, Calif., Oct. 27, 2011  Questcor Pharmaceuticals, Inc. (NASDAQ: ... partnering with the Child Neurology Foundation (CNF) in support ... which will take place October 24-30, 2011, in conjunction ... Savannah, Georgia. As part of this education ...
... Inland Northwest Health Services (INHS), one of ... collaboration with Science Applications International Corporation (SAIC) (NYSE: ... enabling the secure exchange of electronic health information ... part of the Electronic Disability Benefits Eligibility Determination ...
Cached Medicine Technology:Questcor and Child Neurology Foundation Support the 3rd Annual Infantile Spasms (IS) Awareness Week 2Questcor and Child Neurology Foundation Support the 3rd Annual Infantile Spasms (IS) Awareness Week 3Questcor and Child Neurology Foundation Support the 3rd Annual Infantile Spasms (IS) Awareness Week 4
Stainless steel. Lamp is in fiberoptic handle. Green color coding. The blade includes a port that permits delivery of oxygen or other gas mixtures during intubation....
... of the vocal cords in even the most ... like a standard laryngoscope, Viewmax® does not require ... its ability to allow intubation whether you are ... airway. It has a patented lens system that ...
... Stainless steel. Lamp supplied with ... operate on any standard/conventional handle allowing ... illumination without the potential confusion from ... blades offer an easy and cost ...
... The FR-120F, Fujinon's new fiberoptic Naso-Pharyngo-Laryngoscope provides ... patient comfort. The latest in Fujinon ... increased light guide, and a wide 90 ... impressive 3.3mm distal tip diameter. In ...
Medicine Products: