Navigation Links
AMD discovery: New hope for treatment of vision loss
Date:2/20/2008

This release is available in French.

Montreal, February 20, 2008 Scientists have won a major battle in the fight against age-related macular degeneration, or AMD, a blinding eye disease that affects millions of people. An international team, led by researchers at Sainte-Justine Hospital and the Universit de Montral, has identified the deficient receptor that causes the dry form of AMD.

In the February edition of the medical journal PLoS Medicine, the researchers explain how a deficiency of the CD36 receptor prevents the evacuation of oxidized lipids in the eye. Those oxidized lipids in turn accumulate and attack the layers beneath and over the retina thereby causing vision loss.

Our discovery has important implications for the development of new therapies, explains lead researcher, Dr. Sylvain Chemtob, who co-authored the paper with Universit de Montral collaborator Dr. Huy Ong, a professor at the Faculty of Pharmacy, as well as Florian Sennlaub of the Institut national de la sant et de la recherche mdicale (INSERM) in France.

Chemtob, a neonatal researcher at Sainte-Justine Hospital and a professor at the Universit de Montrals Department of Pediatrics and School of Optometry, used mice and rat models to pinpoint the scavenger receptor responsible for retinal degeneration typical of dry AMD. We found that a deficiency in CD36 receptors leads to significant and progressive age-related macular degeneration, he says. CD36 deficiency leads to central vision loss a key feature of dry AMD.

This discovery brings us one step closer to treating dry AMD, which could significantly improve the quality of life of seniors who are most affected by this eye disease, added co-author Dr. Huy Ong. Now that we have also developed the molecules that activate CD 36 receptor, we are working on the validation of the efficacy of these molecules as potential therapeutic agents for dry AMD treatment with prospect at the horizon of 2015.

Wet and dry AMD remain an alarming cause of vision loss in the western world, which according to the AMD Alliance International, affect 30 million people aged 50 and over. Dry AMD is the most pervasive of the disorders and affects 90 percent of AMD cases.


'/>"/>

Contact: Sylvain-Jacques Desjardins
sylvain-jacques.desjardins@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Related medicine news :

1. In Combination With FOLFOX4, the Effect of Erbitux and Avastin On Survival Rates Will Drive Prescription Decisions in the Treatment of Stage III Colon Cancer
2. Varian Medical Systems Announces Symposia on RapidArc Technology for Faster, More Precise Radiotherapy Treatments
3. No Difference Found in Treatments for Acute Kidney Failure
4. Missing Chromosome Improves Response to Brain Tumor Treatment
5. Combo Treatment Best for Melanoma, Advanced Ovarian Cancer
6. Yes, no, maybe so: New model helps identify what works in mental health treatment
7. USAID Awards $70 Million for the Prevention and Treatment of Obstetric Fistula
8. AIDS Healthcare Foundation and NCHADS Partnership Adds 8th Cambodian AIDS Treatment Center in Kirivong
9. Many Prostate Cancers Will Not Need Treatment
10. High-End Treatment Center Moonview Sanctuary Unveils Four New Core Treatment Programs
11. Respiratory Distress Treatment Studies Conflict
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... While it’s often important to take certain medications during the night, finding ... identified a solution. , She developed a prototype for MOTION LIGHT-UP PILL BOX to ... the need to turn on a light when taking medication during the night, allowing ...
(Date:10/13/2017)... ... ... Lori R. Somekh, founder of the Law Office of Somekh & ... and special needs planning attorneys. “Membership in ElderCounsel helps our office remain up to ... with elder law attorneys nationwide,” said Somekh. , ElderCounsel was founded ...
(Date:10/13/2017)... ... 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought ... This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at ... towards children of all ages; it is a non-competitive, non-timed event, which is all ...
(Date:10/13/2017)... ... ... On The Brink”: the Christian history of the United States and the loss of ... William Nowers. Captain Nowers and his wife, Millie, have six children, ten grandchildren, ... Navy. Following his career as a naval aviator and carrier pilot, he spent ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ... introduction of an innovative new design of the shoulder pad. The shoulder pad ... comfort while controlling your pain while using cold therapy. By utilizing ice and water ...
Breaking Medicine News(10 mins):
(Date:9/12/2017)... and NEW YORK , Sept. 12, 2017   ... for global supply chains, has published the first annual edition of its ... of more than 20,400 companies evaluated by EcoVadis, based on Scorecard Ratings ... 2016. ... CSR Risk & Performance Index ...
(Date:9/12/2017)... Sept. 12, 2017  ValGenesis Inc., the global ... is pleased to announce the appointment of Dr. ... its Board of Directors and Chairman of Advisory ... life science companies to manage their entire validation ... paper in this process. Furthermore, ValGenesis VLMS enables ...
(Date:9/9/2017)... Sept. 8, 2017 Dealmed Medical Supplies, ... of medical equipment, supplies, drugs, vaccines, and specialty medical ... into an agreement to acquire Vantage Medical Supplies, a ... Holtsville, New York . ... new and emerging medical practices, will operate under the ...
Breaking Medicine Technology: