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AMAS Test Measures Lethal Replikin Gene Activity in Lung and Other Cancers
Date:12/6/2007

BOSTON, Dec. 6 /PRNewswire/ -- A gene related to rapid replication and lethality has been found to be present in, and to contain some identical protein sequences in, tobacco mosaic virus and non-small cell lung cancer. The early detection diagnostic test for cancer, the AMAS(R) test, appears to measure this gene's activity.

This is the first of a series of reports on the use of a new methodology to isolate "in silico" and track specific gene activity in normal and several disease states.

This newly identified gene has been named the Replikin Peak Gene (RPG). "Replikins(TM)" are a class of proteins containing high concentrations of amino acids lysine and histidine that have been previously determined to be related to rapid replication and virulence. Using proprietary computer algorithms constructed to identify, count, and track historically this class of proteins, replikins have now been analyzed in 130,488 protein and genome sequences. These include all the accession numbers for common strains of influenza and other lethal virus isolations published between 1917 and 2007 in the PubMed repository. Replikins have been found to be concentrated in specific genomic areas. The area of each genome with the highest concentration of continuous replikin peptides has been isolated in silico and named a Replikin Peak Gene (RPG).

Specific RPGs have been identified and quantified in infectious organisms including viruses, bacteria and trypanosomes (malaria). "Upregulation" of the Replikin Peak Gene is evidenced by an increase in the replikin count in the RPG, that is, in the number of replikins per 100 amino acids. For example, in the case of influenza B, which has not to date been lethal, a low replikin count (less than 4) always occurred in influenza B RPGs between 1940 and 2006, and in quiescent periods of influenza A. In contrast, the replikin counts in lethal influenza A virus RPGs increased to over 20, from as much as one to three years before an
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SOURCE Oncolab, Inc.
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