Navigation Links
ALTTO test of dual HER2 blockade finds single agent remains the gold standard
Date:5/31/2014

CHICAGO June 1, 2014 In the largest clinical trial testing the effectiveness of one versus two drugs to treat HER2-positive breast cancer, lapatinib (Tykerb) did not add benefit to the standard trastuzumab (Herceptin) adjuvant therapy, researchers report at the 50th annual meeting of the American Society of Clinical Oncology (ASCO).

MULTIMEDIA ALERT: Video and audio are available for download on the Mayo Clinic News Network.

Results of the phase III clinical trial, ALTTO (Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization study), demonstrated that adding lapatinib to trastuzumab and chemotherapy did not improve patient outcome (defined as disease-free survival or overall survival), and that use of lapatinib significantly increased toxicity.

"These findings suggest that standard adjuvant (post-surgery) treatment for early stage HER2-positive breast cancer should remain trastuzumab in combination with chemotherapy," says Edith A. Perez, M.D., deputy director at large of the Mayo Clinic Cancer Center, and director of the Breast Cancer Translational Genomics Program at Mayo Clinic in Florida.

"The ALTTO trial did not confirm the working hypothesis that adding lapatinib to trastuzumab, either concurrently or sequentially, would improve patient outcome (which was the primary endpoint)," she says. "These results were surprising and very important, as we had hypothesized and hoped that dual blockade of HER2 using two anti-HER2 agents would provide more benefit compared to si
'/>"/>

Contact: Paul Scotti
scotti.paul@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
2. Early Study Finds Some Promise for Lung Cancer Vaccine
3. Narcissists Often Ace Job Interviews, Study Finds
4. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
5. Soy may alleviate hot flashes in menopause, large-scale study finds
6. Study finds doctors have exaggerated fears when starting patients on insulin
7. LSUHSC research finds HPV-related head & neck cancers rising, highest in middle-aged white men
8. Study Finds Antibiotics Best for Appendicitis
9. Supporting LGB children may influence their long-term health, BU study finds
10. Study finds significant skull differences between closely linked groups
11. DNA Testing Finds Allergens, Toxins in Traditional Chinese Medicines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... (PRWEB) August 29, 2014 A team ... wellness solutions, is on its way to the 2014 ... San Diego Convention Center to exhibit and demonstrate a ... in high-noise industrial environments. Etymotic’s safety earphones and high-definition ... technology devices at the show. , The company’s ...
(Date:8/29/2014)... 29, 2014 Today, Gen. Arthur T. ... of America (CADCA) , the nation’s leading substance abuse ... President Obama’s intent to nominate Michael Botticelli as the ... supports President Obama’s decision to nominate Michael Botticelli as ... person to hold this important position at this time ...
(Date:8/29/2014)... Village, IL (PRWEB) August 29, 2014 ... Baty, “The Safety Chick” who profiled a handful ... Safe-Listening Earphones from Etymotic Research. This year, many ... list, and Etymotic, an innovator of hearing wellness ... ears. Their ETY•Kids Safe-Listening Earphones, offered in yellow, ...
(Date:8/29/2014)... PM US Eastern Time)The current method to treat ... produced in animals, to neutralize the toxin. But ... difficulties in developing, producing and maintaining the anti-serums ... by Charles Shoemaker, Ph.D., professor in the Department ... Cummings School of Veterinary Medicine at Tufts University, ...
(Date:8/29/2014)... The microbiology testing sector is one of the ... is also the hugest challenge facing suppliers during these ... of AIDS – still the world’s key health threat ... opportunistic infections (OIs); bioterrorism threat; advancements in technologies for ... Although for certain infections the etiology remains a mystery, ...
Breaking Medicine News(10 mins):Health News:Etymotic’s Safe Listening Earphones and Earplugs Headed For The 2014 NSC Safety Expo 2Health News:CADCA Statement on Nomination of Michael Botticelli as U.S. Drug Czar 2Health News:The Today Show Features ETY•Kids® Safe-Listening Earphones by Etymotic 2Health News:Mice study shows efficacy of new gene therapy approach for toxin exposures 2Health News:Infectious Disease Testing Universe Examined in New VPG Research Report Available at MarketPublishers.com 2Health News:Infectious Disease Testing Universe Examined in New VPG Research Report Available at MarketPublishers.com 3
... Heart Rate Monitor Technology Now Available in ... Commercial Fitness ... the leader in,heart rate monitoring and fitness assessment technology, announced ... heart rate monitors -- can now be seamlessly and cost-effectively,incorporated ...
... September 24, Nominations Now Being,Accepted, NEW YORK, ... Carl M. Loeb University Professor Emeritus at Harvard,University ... Laureates on the,committee responsible for awarding the most ... http://www.prix-galien-usa.com ) will be held on Wednesday, September ...
... April 14 Denise Kehoe has joined,medication therapy ... development. In her new role, she will manage ... of clients across the country., Kehoe brings ... and,operations experience to PharmMD. She recently served as ...
... reveals some promising substance use trends among Ontario adults, its ... significant public health flag. , First the more positive ... significantly declining from 28 percent in 1996 to 20 percent ... from 13 percent in 1996 to just 6 percent in ...
... National,Community Pharmacists Association (NCPA), representing approximately 23,000,independent ... about,pharmacy crime and offering tangible solutions during ... 18). At the forefront of the campaign ... Enforcement Executive Development,Association), and RxPatrol(R) from Purdue ...
... NEW YORK, April 14 When it comes ... often used,interchangeably, often confusing consumers. The Physicians Coalition ... "A label containing specific consumer safety information ... a drug or medical device has been,approved," explained ...
Cached Medicine News:Health News:Polar Introduces Cost-Effective Solution to Reduce Heart Rate Data Cross-Talk 2Health News:Prix Galien USA Welcomes Eighth Nobel Laureate to its Prestigious Award Committee 2Health News:Prix Galien USA Welcomes Eighth Nobel Laureate to its Prestigious Award Committee 3Health News:PharmMD Announces Denise Kehoe as Vice President of Business Development 2Health News:Marijuana use on the rise among Ontario adults, CAMH reports 2Health News:NCPA Declares April 14 - 18 'Protect Your Pharmacy Week' 2Health News:Clarity on Cosmetic Injectable Labeling and Use 2Health News:Clarity on Cosmetic Injectable Labeling and Use 3
(Date:8/28/2014)... , Aug. 28, 2014 Pharmatech initiated ... investment into this game-changing method for matching cancer ... Today, clinical trials target specific cancers, disease staging, ... factors for the cancer, in the first place. ... this information may not be well known to ...
(Date:8/28/2014)... /PRNewswire-iReach/ -- EDGE Orthopaedics, a new entry in ... announce they have received their second FDA 510(k) ... Fracture Plating System. The VIEW Plating ... indications within the mid-foot. The system includes titanium ... (CC), Talonavicular (TN) and Evans plates along with ...
(Date:8/28/2014)... China , Aug. 28, 2014 ... TPI ), a pharmaceutical company that specializes in ... generics and active pharmaceutical ingredients (API) today updates ... Company,s Qionglai Facility (QLF). The ... Practice (GMP) dataset for China Food & Drug ...
Breaking Medicine Technology:Enrollment in Pharmatech's Revolutionary AccessPPM Program Launches 2EDGE Orthopaedics Receives Second FDA Clearance 2TPI Submits Dataset for GMP Inspection at Qionglai Facility (QLF) 2
... 2011 IVD Technology , a UBM Canon medical ... webcast on Challenges in Clinical Lab Automation and IVD ... take place on May 26, 2011 at 2:00 p.m. ET ... here . (Logo:   http://photos.prnewswire.com/prnh/20101214/LA16070LOGO ) ...
... BioPharma, Inc. (PBI) and Gilead Sciences, Inc. will be ... in Pulmonary Fibrosis" session at the 2011 American Thoracic ... 18, 2011.  The poster entitled Differing Effects of ... Following Bleomycin Instillation will be presented by John ...
Cached Medicine Technology:IVD Technology Announces Educational Lecture Webcast: Challenges in Clinical Lab Automation and IVD Instrumentation Development 2Plato BioPharma Presenting Poster at the American Thoracic Society Conference 2
The Trans-Blot transfer cell, used with the included PowerPac 200 power supply, performs efficient, high-intensity electrophoretic transfers. The Trans-Blot cell offers many advantages....
... for a Range of ... Native Enzyme, High Intensity, ... Faster, Higher-Efficiency Transfers via ... Field-Intensity Transfers with Movable ...
... Includes: Criterion cell for running ... with plate electrodes. A blotter fit ... Criterion precast gel system, the Criterion ... the flexibility of the Trans-Blot system ...
A blotter fit for use with the incredible new Criterion precast gel system, the Criterion blotter combines excellent blotting efficiency with the flexibility of the Trans-Blot system and the ease-of-...
Medicine Products: