Navigation Links
ALTTO test of dual HER2 blockade finds single agent remains the gold standard
Date:5/31/2014

CHICAGO June 1, 2014 In the largest clinical trial testing the effectiveness of one versus two drugs to treat HER2-positive breast cancer, lapatinib (Tykerb) did not add benefit to the standard trastuzumab (Herceptin) adjuvant therapy, researchers report at the 50th annual meeting of the American Society of Clinical Oncology (ASCO).

MULTIMEDIA ALERT: Video and audio are available for download on the Mayo Clinic News Network.

Results of the phase III clinical trial, ALTTO (Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization study), demonstrated that adding lapatinib to trastuzumab and chemotherapy did not improve patient outcome (defined as disease-free survival or overall survival), and that use of lapatinib significantly increased toxicity.

"These findings suggest that standard adjuvant (post-surgery) treatment for early stage HER2-positive breast cancer should remain trastuzumab in combination with chemotherapy," says Edith A. Perez, M.D., deputy director at large of the Mayo Clinic Cancer Center, and director of the Breast Cancer Translational Genomics Program at Mayo Clinic in Florida.

"The ALTTO trial did not confirm the working hypothesis that adding lapatinib to trastuzumab, either concurrently or sequentially, would improve patient outcome (which was the primary endpoint)," she says. "These results were surprising and very important, as we had hypothesized and hoped that dual blockade of HER2 using two anti-HER2 agents would provide more benefit compared to si
'/>"/>

Contact: Paul Scotti
scotti.paul@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
2. Early Study Finds Some Promise for Lung Cancer Vaccine
3. Narcissists Often Ace Job Interviews, Study Finds
4. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
5. Soy may alleviate hot flashes in menopause, large-scale study finds
6. Study finds doctors have exaggerated fears when starting patients on insulin
7. LSUHSC research finds HPV-related head & neck cancers rising, highest in middle-aged white men
8. Study Finds Antibiotics Best for Appendicitis
9. Supporting LGB children may influence their long-term health, BU study finds
10. Study finds significant skull differences between closely linked groups
11. DNA Testing Finds Allergens, Toxins in Traditional Chinese Medicines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... 18, 2014 (HealthDay News) -- Daily supplements of selenium ... the development of age-related cataracts among men, a new ... one or both could help prevent cataracts. To investigate ... and Harvard Medical School in Boston, and his colleagues ... and vitamin E. The trial was initially designed to ...
(Date:9/18/2014)... TayganPoint Consulting Group, a leading strategic ... co-founder John Cassimatis was named as one of ... recognizing the region’s top healthcare and life science ... the year. , The Innovation Awards celebrate companies ... to shape the medical industry in Greater Philadelphia ...
(Date:9/18/2014)... Stealth Health Revolution co-founders, Montel ... Frank Davis, founder of Food for Health International ... to announce the new recipe book, "The Simple ... meals using Activz whole-food powders." The Simple ... the Stealth Health Revolution mission to ...
(Date:9/18/2014)... companies can expect to pay higher employee contributions for ... human resource officers about the impact of the Patient ... or Obamacare) conducted by the Darla Moore School of ... May/June. , Patrick Wright, a professor in strategic human ... Chief HR Officers. The survey is distributed to more ...
(Date:9/18/2014)... develop tools that would allow them to clearly view ... neuron fires to the resulting behavior in a whole ... to develop a range of new tools to study ... tool that provides a new way of mapping neural ... between Viviana Gradinaru (BS ,05), assistant professor of biology ...
Breaking Medicine News(10 mins):Health News:Vitamin E, Selenium Supplements Don't Seem to Prevent Cataracts 2Health News:TayganPoint Executive Receives Prestigious Award from Philadelphia Business Journal 2Health News:Montel Williams and Frank Davis Announce New Whole-Food Nutrition Recipe Book, The Simple Scoop, at Natural Products Expo East In Baltimore 2Health News:Montel Williams and Frank Davis Announce New Whole-Food Nutrition Recipe Book, The Simple Scoop, at Natural Products Expo East In Baltimore 3Health News:Survey: Fortune 500 employees can expect to pay more for health insurance 2Health News:Survey: Fortune 500 employees can expect to pay more for health insurance 3Health News:Sensing neuronal activity with light 2Health News:Sensing neuronal activity with light 3Health News:Sensing neuronal activity with light 4Health News:Sensing neuronal activity with light 5
... May 13th at Long Beach Veterans Administration Hospital, ... West Hills/Northridge,Veterans Administration will honor Dr. Richard Merkin, ... the health of American,war veterans. The VA, in ... a clinical research study aimed at,examining diabetic ulcers ...
... Colo., April 24 Heska Corporation,(Nasdaq: HSKA ) announces the following Webcast:, ... Earnings Conference Call on the Web, ... (click on the Q1 2008 Earnings Call link on ... Live over the Internet -- Simply log on to the web at the address ...
... Members, Elect New Member to Board, Reject ... Stockholder Proposals - ... -, MADISON, N.J., April 24 At today,s Annual,Meeting of Stockholders ... 12 current members of the Company,s Board of,Directors and elected nominee Michael ...
... David B. Snow,Jr., chairman & chief executive officer ... scheduled to address the Morgan Stanley Global Healthcare,Unplugged Conference ... The presentation at the Ritz-Carlton, Key Biscayne, will begin ... financial officer, is also,scheduled to attend., The presentation ...
... New Call Center, WASHINGTON, April 24 On ... contacting nearly 570,000,recent combat veterans to ensure they know ... reach out and touch every veteran of Operation Enduring,Freedom ... are here for them,",said Dr. James B. Peake, Secretary ...
... concepts through abstract cases more likely to retain knowledge, ... The use of "real-world" concrete examples doesn,t help students ... that challenges the widespread use of this approach in ... who learned a mathematical concept with concrete examples couldn,t ...
Cached Medicine News:Health News:Veterans Honor Dr. Richard Merkin During Research Week 2Health News:Webcast Alert: Heska Announces First Quarter 2008 Earnings Conference Call Webcast 2Health News:Wyeth Holds Annual Meeting of Stockholders 2Health News:Wyeth Holds Annual Meeting of Stockholders 3Health News:Wyeth Holds Annual Meeting of Stockholders 4Health News:Medco CEO to Present at the Morgan Stanley Global Healthcare Unplugged Conference 2Health News:VA Calling All Recent Combat Vets 2Health News:'Real World' Examples Don't Make Math Any Easier 2
(Date:9/18/2014)... SAN ANTONIO, Texas , Sept. 18, 2014  Casen ... vessels, skin and muscles to harden.  His case is one ... (GVM) in the world.  The only hospital in ... few in the world, offering treatment with the dual wave-length ... in San Antonio . Using a laser ...
(Date:9/18/2014)... LONDON , Sept. 18, 2014 ... companies. Competition for innovation, increasing clinical development costs, ... with the fast-changing environment are important factors driving ... and clinical trial costs continue to rise due ... Studies conducted by industry think tanks suggest ...
(Date:9/18/2014)... NORTHVALE, N.J. , Sept. 18, 2014 /PRNewswire/ ... Gianluca DeNovi , Ph.D. to its corporate ... DeNovi is an instructor at the Harvard Medical ... Bio-Medico of Rome.  He received his Masters degree ... and Control Systems from the University of Bologna. After ...
Breaking Medicine Technology:Methodist Children's Hospital In San Antonio, TX Only Hospital In The U.S. Treating Rare Vascular Condition With Dual Wave-Length Laser 2Patient Recruitment in Asia Biotech and Pharma Companies 2Patient Recruitment in Asia Biotech and Pharma Companies 3ADM Tronics Appoints Gianluca DeNovi, Ph.D. To Advisory Board 2ADM Tronics Appoints Gianluca DeNovi, Ph.D. To Advisory Board 3
Cross action, round handle, maximum opening 2.8 mm....
Irrigating nucleus chopper, tip angled 30 to side wedge shaped inferior edge with blunt tip and front notch for engaging iris end opening, 19 gauge. For use in the right hand....
Irrigating nucleus chopper, wedge-shaped inferior edge with, blunt tip, 0.6 mm dual sideports, 20 gauge....
Irrigating nucleus chopper, semi-sharp, wedge shaped inferior edge with a pointed tip, dual sideports, 20 gauge. For Phakonit cataract surgery....
Medicine Products: