ALPCO Launches GLP-1 (Active 7-36) and (7-36 and 9-36) ...(rdioprotective and vasodilatory role for...),Health

These efforts are currently hampered by a lack of good tools, as we are reminded by Mr. LaMarca: "With all of the drug development and basic research efforts ongoing, there is no accessible commercial method for quantification of circulating GLP-1, either in its active or total form. Researchers have been forced to use assays that have several systemic issues including: lack of reproducibility, inability to detect significant physiological shifts of GLP-1 resulting from meal tolerance or therapeutic intervention and lack of sensitivity. Since fasting levels are so low, researchers are often unable to establish a baseline."

Marking a turning point in GLP-1 ELISA technology, the ALPCO/Epitope ELISA answers the need for a reproducible, highly sensitive assay to measure Active (7-36) GLP-1. This offering is enhanced by a corresponding method for detecting combined (7-36 and 9-36) fragments. The Active (7-36) assay is sensitive to 0.2 pmol/l, allowing researchers to discern low baseline values. Additionally, both kits demonstrate a marked stimulation index for fed versus fasted samples, a capability that has been lacking for commercial kits previously available to researchers.

(1) Suarez-Pinon W, et al. 2008. Diabetes; 57 (12): 3281-3288.

(2) Ban K, et al. 2008. Circulation; 117: 2340-2350

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