Navigation Links
ALPCO Launches GLP-1 (Active 7-36) and (7-36 and 9-36) ELISA Kits

SALEM, N.H., Sept. 22 /PRNewswire/ -- ALPCO is pleased to introduce a pair of ELISA kits for research use only for the easy and accurate measurement of both active (7-36) GLP-1 and combined (7-36 and 9-36) GLP-1 fragments.

GLP-1, an incretin hormone, has been a focus of the diabetes & obesity research community recently. The first incretin therapy was approved by the FDA in 2006, and early clinical data demonstrates that these therapies are delivering good results for some patients with Type II diabetes. As more incretin-based drugs are identified and proceed through the clinical development process, the area of research that focuses on elucidating the physiological impact of incretin hormones has taken on greater significance. Craig LaMarca, a scientist and technical sales advisor at ALPCO, points out: "Basic science researchers are establishing mechanisms and principles for why GLP-1 is an attractive therapeutic target. Along these same lines, but further down in the process are pharmaceutical companies who are trying to establish the functionality of potential drug candidates in their ability to increase circulating levels of GLP-1... Although most of the work currently is focusing on diabetes, recent research has implied utility of targeting GLP-1 in other therapeutic areas." For example, studies have shown that GLP-1 agonists and/or DPP-IV inhibitors offer Beta cell protection in rodents(1) - an indication that the same may be accomplished in humans, offering the hope of altering the progression of Type II diabetes. On the other hand, studies have also proposed that there is a cardioprotective and vasodilatory role for the 9-36 fragment, a peptide once thought to be relatively biologically inactive(2).

These efforts are currently hampered by a lack of good tools, as we are reminded by Mr. LaMarca: "With all of the drug development and basic research efforts ongoing, there is no accessible commercial method for quantification of circulating GLP-1, either in its active or total form. Researchers have been forced to use assays that have several systemic issues including: lack of reproducibility, inability to detect significant physiological shifts of GLP-1 resulting from meal tolerance or therapeutic intervention and lack of sensitivity. Since fasting levels are so low, researchers are often unable to establish a baseline."

Marking a turning point in GLP-1 ELISA technology, the ALPCO/Epitope ELISA answers the need for a reproducible, highly sensitive assay to measure Active (7-36) GLP-1. This offering is enhanced by a corresponding method for detecting combined (7-36 and 9-36) fragments. The Active (7-36) assay is sensitive to 0.2 pmol/l, allowing researchers to discern low baseline values. Additionally, both kits demonstrate a marked stimulation index for fed versus fasted samples, a capability that has been lacking for commercial kits previously available to researchers.

(1) Suarez-Pinon W, et al. 2008. Diabetes; 57 (12): 3281-3288.

(2) Ban K, et al. 2008. Circulation; 117: 2340-2350

Media contact: Kate Kaplan, 1-800-592-5726 x220

Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Us TOO Launches National SEA Blue Campaign for Prostate Cancer Awareness Month
2. UPMC Health Plan Launches New Personal Health Record
3. Launches Video Contest for Young Directors
4. Academy of General Dentistry Launches Campaign to Focus on Tooth Erosion
5. Keeping Kids Healthy and Fit: The New York Kids Club Launches a Revolutionary New Fitness Program
6. Patient Advocate Foundation Launches Program to Help Uninsured Virginians with Chronic, Debilitating and Life-Threatening Illness Access Quality Healthcare
7. Mannatech Launches Phase One of New Sales and Training Tools
8. Coalition for Pulmonary Fibrosis Launches Aggressive Ad Campaign Directed at United States Congress
9. Actavis Launches Carvedilol Tablets in the U.S.
10. MedQuist Re-launches New, Improved Web Site
11. Elsevier launches new journal: Stem Cell Research
Post Your Comments:
(Date:11/26/2015)... (PRWEB) , ... November 26, 2015 , ... ... a real-time eReferral system for diagnostic imaging in the Waterloo region. Using the ... and Nuclear Medicine tests directly from their electronic medical record (EMR) without the ...
(Date:11/26/2015)... ... November 26, 2015 , ... The Catalent ... and the need to integrate dose form selection in early phase drug development. ... membership organization supporting and bringing together the UK’s emerging life sciences companies, corporate ...
(Date:11/26/2015)... ... 2015 , ... PRMA Plastic Surgery is updating their record books yet again ... free flap breast reconstruction surgery! , “What an accomplishment for the PRMA team, says ... and it’s an honor to have served all of these women.” , PRMA is ...
(Date:11/26/2015)... ... November 26, 2015 , ... Pixel Film Studios brings ... with ProTrailer: Vintage. This newly styled ProTrailer pack comes with 30 all-new vintage-inspired ... font, giving users limitless opportunities to stylize and create designs quickly and easily, ...
(Date:11/26/2015)... ... November 26, 2015 , ... Indosoft Inc., developer and distributor ... application server to improve system efficiency and reliability. , The new Q-Suite 6 platform ... standards, the system avoids locking itself into a specific piece of software for many ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... Países Bajos, November 26, 2015 ... fotodinámica de Bremachlorin para el cáncer avanzado.   ... con la terapia fotodinámica de Bremachlorin para el cáncer ... enfoque combina la inmunoterapia con la terapia fotodinámica de ... Clinical Cancer Research . --> Clinical Cancer ...
(Date:11/26/2015)... 26, 2015 ... aanpak combineert immunotherapie met Bremachlorin-photodynamische therapie voor ... ) --> ... ) Uit ... Centrum (LUMC) blijkt ...
(Date:11/26/2015)... 2015 3D bioprinting market is ... a new report by Grand View Research Inc. Rising prevalence ... demands kidney transplantation is expected to boost the market growth, ... organ transplantation. --> 3D bioprinting market is ... a new report by Grand View Research Inc. Rising prevalence ...
Breaking Medicine Technology: