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ALPCO Announces the Launch of Rat and Mouse Proinsulin ELISA Kits
Date:1/26/2010

ays, illustrating their utility in the field.  

A hallmark of these new assay systems are their defined cross reactivity with both proinsulin I and II.  Peter Wunderli, PhD, Laboratory Operations Manager at ALPCO, remarks on the significance of this advancement, "Rat proinsulin, as for mouse, is expressed as two isoforms. No one knows whether isoform expression is individually influenced by the disease.  Until that is established, there is a need to be able to measure the total proinsulin.  Our kits do that with excellent specificity and robustness."  

Several factors, not the least of which being the variability in expression of proinsulin I and II between mice and rats, makes the ALPCO species-specific assay kits the most attractive option for researchers expecting to quantify total proinsulin in their pre-clinical models.

While research has established that the total ratio of circulating proinsulin relative to insulin and c-peptide is altered in the diabetic and pre-diabetic state in humans, multiple barriers in the ability to accurately measure rodent proinsulin means relatively limited data has been available regarding concentrations of this molecule in rats and mice, both of which are widely used models in the diabetes research community.  

Craig LaMarca, a scientist and technical sales advisor with ALPCO, stated: "Typically in humans, proinsulin is elevated as a result of impaired processing in the beta cell, which is a characteristic of type 2 diabetes.  In cases of beta cell dysfunction, including type 2 diabetes and pre-diabetes, the proinsulin secretion ratio can increase to >60% (from 5% in a non-diabetic state).  Until now, there has not been a viable method for measuring rodent proinsulin, which would allow researchers to establish models for testing targeted therapies or interventions in the pre-clinical setting.  This ne
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