Navigation Links
ALK rearrangement found in nearly 10 percent of patients in Lung Cancer Mutation Consortium
Date:7/5/2011

ALK rearrangement has been found in 9.6% of lung cancer patients tested in the Lung Cancer Mutation Consortium, and MET amplification in another 4.1%, reflecting how many patients might benefit from targeted therapies such as crizotinib, according to research presented at the 14th World Conference on Lung Cancer in Amsterdam, hosted by the International Association for the Study of Lung Cancer (IASLC).

The Lung Cancer Mutation Consortium (LCMC), involving 14 U.S. cancer centers, was established to evaluate genetic alterations in 1,000 patients with advanced lung adenocarcinoma.

CLIA-certified labs at each site are using multiplex assays to profile eight genes previously linked to lung cancer, AKT1, BRAF, EGFR, HER2, KRAS, MEK1, NRAS and PIK3CA. Two other genes, ALK and MET, have been tested by fluorescence in situ hybridization (FISH) for rearrangements or amplifications.

"High quality molecular diagnosis for multiple markers can be achieved in a reasonable period of time to select patients for targeted therapy," said Prof. Marileila Varella Garcia, Ph.D., a professor of medical oncology at the University of Colorado School of Medicine.

Put simply, ALK rearrangement occurs when the head (promoter) and tail (active domain) of the gene split. Either part may then fuse with another gene. When the active domain of ALK fuses with a hyperactive promoter such as the EML4 promoter, it creates a fusion oncogene that has been associated with non-small cell lung cancer.

Lung cancer patients with ALK rearrangement have been found in previous studies to respond well to crizotinib, an ALK inhibitor.

In the LCMC study, researchers looked for ALK fusion with EML4 (EML4-ALK) or other partners, and MET amplification. ALK rearrangement was detected in 9.6% of patients and MET amplification in 4.1%.

ALK mutations were associated with younger age, median 52.3 years; ALK negative subjects had a median age of just under 60 years. ALK positive subjects were more likely to be never-smokers than ALK negative subjects (64% vs. 31%), less likely to have smoked in the past (33% vs. 61%) and more likely to have experienced liver metastasis (21% vs. 8%). No association was found between ALK-positive status and sex, gender, stage or brain metastasis.


'/>"/>

Contact: Rene McGaw
renee.mcgaw@ucdenver.edu
31-205-493-413
International Association for the Study of Lung Cancer
Source:Eurekalert

Related medicine news :

1. NIH, USU study maps hotspots of genetic rearrangement
2. Scientists identify KRAS rearrangements in metastatic prostate cancer
3. The Samuel Waxman Cancer Research Foundation awards more than $3.1 million in grants
4. Autism Speaks and Flutie Foundation join HPs Hacking Autism to develop touch apps for autism
5. Massachusetts General Hospital, Iacocca Foundation announce promising results of Phase I diabetes trial
6. New genetic risk factors of lupus found in study of African-American women
7. Sleep switch found in fruit flies
8. The New York Stem Cell Foundation announces new initiative for Parkinsons disease
9. Damon Runyon Cancer Research Foundation awards $3.45 million to 9 top young clinical investigators
10. Possible susceptibility genes found in neurodegenerative disorder
11. SIR Foundation sets research priorities for minimally invasive treatments for MS patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2017)... ... 2017 , ... Galena, Alaska, has a population of less than 500 people. ... was targeted to build a nuclear plant by the TOSHIBA Corporation. , In “The ... Yoder describes the journey to get power to his small town, off the electrical ...
(Date:5/21/2017)... ... May 19, 2017 , ... HealthSmart, the largest ... James (Jim) Vertino as Chief Information Officer (CIO). He will be joining HealthSmart ... innovation and business performance. He defines strategic roadmaps by reimagining business processes—bridging the ...
(Date:5/21/2017)... ... May 21, 2017 , ... Florida Pain Relief Group, a division ... newest location at 109 Silver Palm Ave., Melbourne, on Monday, May 22. Initially the ... opening of the Melbourne practice, PPOA operates 23 pain management clinics in Florida and ...
(Date:5/19/2017)... ... May 19, 2017 , ... A leader in ... Charlotte recently began recruitment efforts for the inaugural cohort of its online ... knowledge and expertise to approach and address the unique nuances healthcare organizations face ...
(Date:5/19/2017)... FL (PRWEB) , ... May 19, 2017 , ... ... asset protection services and retirement planning assistance to families and business owners in ... Sclerosis Society to advocate for MS sufferers and their families. , Multiple sclerosis ...
Breaking Medicine News(10 mins):
(Date:5/18/2017)... 2017  Bayer announced today that the latest research ... at the 53 rd Annual Meeting of the ... 2-6 in Chicago . ... colorectal, liver and thyroid cancers, as well as lymphomas, ... CHRONOS-1 trial of copanlisib in patients with relapsed or ...
(Date:5/15/2017)... May 15, 2017 Enterin Inc., a privately-held CNS ... developing novel compounds to treat Parkinson,s disease (PD), has enrolled ... a Phase 1/2a randomized, controlled, multicenter study involving patients with ... enroll 50 patients over a 9-to-12-month period. The first stage ... patients with PD. Participating sites include Denver ...
(Date:5/11/2017)... -- Thornhill Research Inc. ( Toronto, Ontario, Canada ... five-year, firm-fixed-priced, indefinite-quantity/indefinite-delivery contract by the U.S. Department ... ( Ottawa, Ontario, Canada ) to ... to patients requiring emergency medical procedures in a ... have been a longtime partner with Thornhill Research ...
Breaking Medicine Technology: