Navigation Links
AIDS patients face higher risk of HPV-related cancers as immunosuppression grows
Date:7/31/2009

Risk of human papillomavirus (HPV)-associated cancers is greater for people living with AIDS and increases with increasing immunosuppression, according to a new study published online July 31 in the Journal of the National Cancer Institute.

Although the risk of HPV-associated cancers is known to be higher among people with AIDS, the extent to which HIV-related immunosuppression plays a role is unclear.

Anil K. Chaturvedi, Ph.D., of the Infections and Immunoepidemiology Branch at the National Cancer Institute, in Rockville, Md., and colleagues used data from a cancer registry for almost 500,000 persons diagnosed with AIDS between 1980 and 2004 to estimate risks for HPV-associated cancers. These include cancers of the anus, cervix, oropharynx, penis, vagina, and vulva. The researchers also evaluated the relationship between immunosuppression and incidence of these cancers by counting CD4 T-cells at AIDS onset. Incidence was compared across three periods (1980�, 1990�, and 1996�).

People with AIDS had a statistically significant higher risk for all HPV-associated cancers. From 1996 (when highly active antiretroviral therapy was introduced) through 2004, a low CD4 T-cell count was associated with an increased risk of invasive anal cancer among men. This risk was higher in 1996� than in 1990�. Both increases in risk were statistically significant.

"Given that individuals currently infected with HIV may obtain little benefit from available HPV vaccinesour results underscore the need for effective screening for cervical cancer and anal cancer among persons with HIV infection or AIDS," the authors write.

In an accompanying editorial, Howard D. Strickler, M.D., of Albert Einstein College of Medicine, Department of Epidemiology & Population Health, said the study provides novel evidence associating HPV-related invasive cancers with the level of immunosuppression in HIV-positive patients. However, he also cautioned that while highly suggestive the available data to date collectively still fall short of proving a biological relationship between HIV/AIDS and HPV-related cancers. Regarding the study by Chaturvedi et al, for example, after mentioning several important strengths to that study, Dr. Strickler also mentions:

"Nonetheless, it must additionally be acknowledged that these associations between human papillomavirus-related cancers and markers of immunosuppression were of moderate strength, varied between cancer types, and await confirmation."


'/>"/>

Contact: Steve Graff
jncimedia@oxfordjournals.org
301-841-1285
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. Living Green Marketplace Announces the Cancer Care Wellness Box to Bring Comfort to Cancer Patients During Medical Treatment
2. Immune responses to flu vaccine are diminished in lupus patients
3. Tabyat Partners, LLC. Launches iluvmydoc.com™, to Better Connect Patients with Doctors
4. NHLBI stops study of pulmonary hypertension treatment in sickle cell patients
5. Patients With Bipolar Disorder at Increased Risk for Wide Range of Health Problems, Thomson Reuters Study Finds
6. Photos: One Million Patients Choose Hologics NovaSure(R) System Over Hysterectomy
7. Save Swine Flu Drugs for Younger Patients, Study Urges
8. Surveyed Oncologists Expect to Prescribe Provenge to about Half of Their Prostate Cancer Patients if the Vaccine is Approved
9. Fort Lauderdale Plastic Surgery Practice and Dr. Robert Rothfield Reaching Out to Patients with Expansive New Website
10. Study: Bariatric surgery patients have 67 percent lower chance of complications at top hospitals
11. Medicare Cuts Will Force Many Cancer Centers To Close, Stop Seeing Medicare Patients, Lay Off Staff, According To ASTRO Survey
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... San Diego, CA (PRWEB) , ... June 24, 2016 , ... ... up with the American Cancer Society and the Road To Recovery® program to drive ... care to seniors and other adults to ensure the highest quality of life and ...
(Date:6/24/2016)... Norcross, Georgia (PRWEB) , ... June 24, 2016 ... ... Year” awards today at the Clinical Decision Making in Emergency Medicine conference in ... who have authored journal articles published in Emergency Medicine Practice and ...
(Date:6/24/2016)... ... 2016 , ... Strategic Capital Partners, LLC (SCP) in concert ... capital for emerging technology companies. SCP has delivered investment events and professional ... than a million dollars of capital investment for five companies. The ...
(Date:6/24/2016)... ... June 24, 2016 , ... Today, ... stem (iPS) cells and other difficult to transfect cells, announces its launch of ... PluriQ™ G9™ Gene Editing System is a complete system for culturing and ...
(Date:6/24/2016)... ... June 24, 2016 , ... To succeed under value-based payments, ... are unsure how to move forward, given the need to sustain current operations. ... tailored to an organization’s specific needs. , PYA Principal Martie Ross states, “Healthcare ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Leading ... that address medical conditions resulting from a breakdown ... has appointed Greg Doyle as chief ... Leading BioSciences, executive management team and board of ... chief financial officer. He will provide continued leadership ...
(Date:6/23/2016)... June 23, 2016 Research and ... in Europe 2016 Edition: The New Global Agenda " ... OTC Distribution in Europe - ... explores and tracks change. It identifies the driving factors coming ... the consumer healthcare industry now and in the future. It ...
(Date:6/23/2016)... June 23, 2016 The ... the development of combination therapies trend is expected ... treatment of CLL were available only in the ... are chlorambucil in combination with prednisone, and a ... a growing trend of developing combination therapies to ...
Breaking Medicine Technology: