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AGI Dermatics Data Indicates 8 Oxo-Guanine Repair Enzyme OGG1 Encapsulated in Liposomes, Reduces MMP-1, Increases Collagen and Enhances DNA Repair
Date:2/11/2008

Clinical Data Presented at the 66th Annual Meeting of the American Academy

of Dermatology

FREEPORT, N.Y., Feb. 11 /PRNewswire/ -- AGI Dermatics presented clinical research that indicates the 8-oxo-guanine DNA glycosylase (OGG1) encapsulated in liposomes is an effective agent in treating photodamaged skin by enhancing DNA repair, reducing MMP-1 secretion and increasing collagen production in UV irradiated skin cells. The data was presented in two scientific posters at the 66th Annual Meeting of the American Academy of Dermatology in San Antonio.

"The development of effective skin protection against photoaging and even skin cancer requires detailed understanding of the underlying molecular mechanisms of the skin, a belief that is at the core of all our research," said Daniel Yarosh, PhD, President, AGI Dermatics. "These studies demonstrate that OGG1 encapsulated in liposomes has a profound effect on repairing the cellular damage that is caused by the sun and other environmental stressors. It's a first step to understanding and reversing symptoms of premature skin aging."

The first study examined the question whether OGG1 can repair the nuclear and mitochondrial oxidative damage caused by the irradiation with solar stimulating UV (ssUV) of sub-confluent normal human epidermal keratinocytes (NHEK).

For the test, sub-confluent NHEK were irradiated with ssUV to induce the intrinsic apoptotic pathway, as determined by the activation of the initiator caspase-9 in a dose-dependent manner. Following irradiation, the keratinocytes were treated with OGG1 for up to 24 hours. The study then looked at the results of the OGGI on caspase-9 activation following ssUV irradiation of sub- confluent NHEK.

The treatment of ssUV stimulated NHEK showed that ssUV induced less than two-fold caspase-9 activation, and that OGG1 does not have significant effects on caspase-9 levels in ssUV irradiated cells. Accordingly, this
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SOURCE AGI Dermatics
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