Navigation Links
AGI Dermatics Data Indicates 8 Oxo-Guanine Repair Enzyme OGG1 Encapsulated in Liposomes, Reduces MMP-1, Increases Collagen and Enhances DNA Repair
Date:2/11/2008

Clinical Data Presented at the 66th Annual Meeting of the American Academy

of Dermatology

FREEPORT, N.Y., Feb. 11 /PRNewswire/ -- AGI Dermatics presented clinical research that indicates the 8-oxo-guanine DNA glycosylase (OGG1) encapsulated in liposomes is an effective agent in treating photodamaged skin by enhancing DNA repair, reducing MMP-1 secretion and increasing collagen production in UV irradiated skin cells. The data was presented in two scientific posters at the 66th Annual Meeting of the American Academy of Dermatology in San Antonio.

"The development of effective skin protection against photoaging and even skin cancer requires detailed understanding of the underlying molecular mechanisms of the skin, a belief that is at the core of all our research," said Daniel Yarosh, PhD, President, AGI Dermatics. "These studies demonstrate that OGG1 encapsulated in liposomes has a profound effect on repairing the cellular damage that is caused by the sun and other environmental stressors. It's a first step to understanding and reversing symptoms of premature skin aging."

The first study examined the question whether OGG1 can repair the nuclear and mitochondrial oxidative damage caused by the irradiation with solar stimulating UV (ssUV) of sub-confluent normal human epidermal keratinocytes (NHEK).

For the test, sub-confluent NHEK were irradiated with ssUV to induce the intrinsic apoptotic pathway, as determined by the activation of the initiator caspase-9 in a dose-dependent manner. Following irradiation, the keratinocytes were treated with OGG1 for up to 24 hours. The study then looked at the results of the OGGI on caspase-9 activation following ssUV irradiation of sub- confluent NHEK.

The treatment of ssUV stimulated NHEK showed that ssUV induced less than two-fold caspase-9 activation, and that OGG1 does not have significant effects on caspase-9 levels in ssUV irradiated cells. Accordingly, this
'/>"/>

SOURCE AGI Dermatics
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine news :

1. U.S. Pharmacopeia 8th Annual MEDMARX(R) Report Indicates Look-Alike/Sound-Alike Drugs Lead to Thousands of Medication Errors Nationwide
2. New Study Indicates Decreasing Prescription Copayments Results in Increased Adherence for Patients with Chronic Diseases
3. Study Indicates Strong Consumer Preference to Fix Medicare Part D and Medicaid Flaws Threatening Access to Prescription Drugs
4. Breast Cancer Imaging Study Indicates Breast-Specific Gamma Imaging (BSGI) Is a Strong Adjunct Imaging Modality to Mammography and Ultrasound
5. Research Indicates Nearly 25 Percent of Supplements Are Contaminated With Steroids, Stimulants and Banned Substances
6. Study indicates pregnancy does not harm chances of survival from cancer
7. Mayo Clinic study indicates medication for ADHD may help student outcomes
8. New Research From America On the Move Foundation Indicates American Weight Loss Efforts Stalling
9. Turning on adult stem cells may help repair bone
10. Stem cells could be used for cardiac repair
11. Intensive training post-spinal cord injury can stimulate repair in brain and spinal cord
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... York, NY (PRWEB) , ... August 29, 2015 , ... ... unofficial end of summer (which astronomically, officially ends on September 22nd this year). For ... summer-induced cyber security hangovers linger on which could prove far more costly than a ...
(Date:8/29/2015)... ... 2015 , ... The popular television program VOICES IN AMERICA, hosted by legendary ... be devoting an entire short segment to the subject of diabetes. Diabetes is a ... a daily basis, but recent advancements in medical science may prove to be a ...
(Date:8/28/2015)... ... , ... An online provider of CPAP machines, masks, supplies, and accessories, My ... affordable by offering shipping at no cost to you, directly to your door on ... size. My Cpap Store is located in Las Vegas, Nevada. , Sleep apnea is ...
(Date:8/28/2015)... ... , ... With the goal of furthering music education programs in schools, the ... County Fairgrounds in Mendon, IL on May 30th, 2015. Backed once again by Best ... the underfunded school districts of Mendon and its neighboring town of Quincy, IL. Best ...
(Date:8/28/2015)... ... August 28, 2015 , ... The 6th Annual Survivor in the City, ... added yet another accolade to its cadre of widespread support—an official letter of support ... help of the medical community and the University of Illinois at Chicago’s Department of ...
Breaking Medicine News(10 mins):Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 2Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 3Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 4Health News:My Cpap Store Now Offering Delivery Special 0 Cost to You 2Health News:Best Drug Rehabilitation Interviews Country-Rock Duo Highway Run at the 2015 "Music With A Mission" Benefit Concert 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 3
... MOBILE PHONE ALERT: Evidence and recommendations from scientists and physicians ... June 19 Prominent researchers around the world are raising ... Today there are 4 billion cell phones in the world, ... -- PDAs, Wi-Fi, cordless phones, baby monitors and more -- ...
... Pa., June 19 Kensey Nash Corporation (Nasdaq: ... innovative solutions and technologies for a wide range of ... adopted a stockholders, rights plan. The rights plan is ... potentially coercive takeover practices or takeover bids and to ...
... , BEIJING, June 19 /PRNewswire-Asia-FirstCall/ ... CMED ), a leading China-based medical device,company that develops, ... unaudited preliminary financial results for,the fourth fiscal quarter (,4Q ... March 31, 2009 (,FY2008,). The Company,s 2008 fiscal ...
... ... to be recognized with prestigious professional designation , ... Philadelphia, PA (Lexis Nexis) June 19, 2009 -- Galfand Berger, a Philadelphia-based ... decades, today announced that three of its attorneys have been named by Pennsylvania Super Lawyers ...
... Bariatric Advantage, Division ... scheduled for June 21-26 in Dallas, TX. , ... Irvine, CA (PRWEB) June 19, 2009 -- Bariatric Advantage, Division of Catalina ... June 21-26 in Dallas, TX. "The new products have been developed to meet the ...
... for Good Times , , MALIBU, Calif., June 18 ... championship event that features the highest quality wave-riding skills the ... Saturday and Sunday, June 20 and June 21. The ... help children with Cancer, is free to the public. , ...
Cached Medicine News:Health News:'Radiation Rescue: 4 Steps to Safeguard Your Family from the Other Inconvenient Truth - The Health Hazards of Wireless Technology' 2Health News:Kensey Nash Corporation Adopts Stockholder Rights Plan 2Health News:Kensey Nash Corporation Adopts Stockholder Rights Plan 3Health News:Kensey Nash Corporation Adopts Stockholder Rights Plan 4Health News:China Medical Technologies Announces Selected Unaudited Preliminary Financial Results for the Fourth Fiscal Quarter and Full Year Ended March 31, 2009 2Health News:China Medical Technologies Announces Selected Unaudited Preliminary Financial Results for the Fourth Fiscal Quarter and Full Year Ended March 31, 2009 3Health News:Three Attorneys from Philadelphia's Galfand Berger Honored as Pennsylvania Super Lawyers 2Health News:Bariatric Advantage to Introduce Ten (10) New Products at ASMBS 2
(Date:8/28/2015)... y LONDRES, 28 de agosto de 2015 ... anunció hoy su participación en el  Congreso de ... soluciones cardiológicas más recientes y novedosas, entre ellas ... conectan a las personas y la tecnología con ... a diagnosticar, guiar los tratamientos y permitir atención ...
(Date:8/28/2015)... 2015 The global mHealth ... billion by 2020, growing at a CAGR of 47.6% ... by Grand View Research, Inc. Monitoring services is expected ... 2014 to 2020.      (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ... rising incidences of chronic diseases such as cancer, heart ...
(Date:8/27/2015)... Aug. 27, 2015  A recent study by ... Journal, compared the Arthrosurface HemiCAP® Wave implant, which ... an "onlay" design implant for isolated patellofemoral disease. ... function and pain scores, none of the patients ... (OA). However, 53% of the patients in the ...
Breaking Medicine Technology:Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 2Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 3Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 4Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 5mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 2mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 3mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 4mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 5Study Demonstrates Dramatic Reduction in Progression of Osteoarthritis with the Arthrosurface "Inlay" Patellofemoral Implant Design Compared to Traditional "Onlay" Implant 2Study Demonstrates Dramatic Reduction in Progression of Osteoarthritis with the Arthrosurface "Inlay" Patellofemoral Implant Design Compared to Traditional "Onlay" Implant 3
... , SCOTTSDALE, Ariz., Oct. 14 When it comes ... it is easy to point a finger at a ... regulations. But new data from the 2009 Leadership Skills ... ( http://www.gottochange.com ), indicates that the root ...
... INDIANAPOLIS, Oct. 14 Eli Lilly and Company (NYSE: ... Tippecanoe Laboratories manufacturing facility to Evonik Industries AG, one ... located in Lafayette, Indiana, will remain in operation with ... and specialty chemical and animal health products. In connection ...
Cached Medicine Technology:Slumps in Pharmaceutical Profitability Tied to Insufficient Management Training 2Slumps in Pharmaceutical Profitability Tied to Insufficient Management Training 3Lilly to Sell Tippecanoe Manufacturing Site to Evonik Industries 2Lilly to Sell Tippecanoe Manufacturing Site to Evonik Industries 3Lilly to Sell Tippecanoe Manufacturing Site to Evonik Industries 4
... Eppendorf Reference Series 2000 Pipette is a ... a compact and robust design, and superior ... used to operate the measuring stroke and ... Product features:Eppendorf "pipette/tip" system ensures utmost accuracy ...
Inquire...
... Pipette is a synonym for pipetting accuracy, ... design, and superior operating comfort. Its single, ... measuring stroke and blow-out as well as ... ensures utmost accuracy and precision. Ejection sleeve ...
... Reference Series 2000 Pipette is a synonym ... compact and robust design, and superior operating ... to operate the measuring stroke and blow-out ... features:Eppendorf "pipette/tip" system ensures utmost accuracy and ...
Medicine Products: