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AGA offers new recommendations for CRC surveillance for certain patients with IBD
Date:2/16/2010

Bethesda, MD (Feb. 16, 2010) Certain patients with inflammatory bowel disease (IBD), both ulcerative colitis and Crohn's disease of the colon, have an increased risk of developing colorectal cancer compared to individuals without IBD. A number of factors contribute to the increase in risk, which necessitates an individualized and sensible approach to surveillance in patients, according to a new medical position statement and technical review published by the American Gastroenterological Association in its official journal, Gastroenterology.

"The increased risk of developing colorectal cancer in certain patients with IBD prompted the AGA to look at current diagnosis and management protocols to ensure that our patients are receiving the highest level of treatment," according to Francis A. Farraye, MD, primary author of the manuscript. "The recommendations we developed will help guide gastroenterologists to identify high-risk individuals and develop surveillance plans based on each patient's unique situation."

While IBD is relatively rare in the general population, it remains one of the three high-risk conditions predisposing patients to CRC, along with Lynch syndrome and familial adenomatous polyposis. "Although certain patients with IBD have an increased risk of developing colorectal cancer, there is evidence that the risk of developing cancer has decreased over the past several decades," stated senior author Steven Itzkowitz, MD.

Other findings of the medical position statement on diagnosis and management of CRC in IBD patients include:

  • Disease duration, more extensive disease, severity of inflammation, primary sclerosing cholangitis (disease of the bile ducts that leads to liver damage), and a positive family history of sporadic CRC are all associated with an increased risk of developing CRC.
  • Dysplasia (abnormal cells) detected on biopsy is currently considered the best marker for CRC risk in IBD. '/>"/>

Contact: Aimee Frank
media@gastro.org
301-941-2620
American Gastroenterological Association
Source:Eurekalert

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