Navigation Links
ADVANCE diabetes trial results confirm no evidence of safety risk
Date:2/28/2008

he ADVANCE trial and published in The Lancet in September 2007.

In ADVANCE and ACCORD, the intensive treatment arm targeted blood glucose levels below those recommended in current treatment guidelines because previous studies suggest that reducing blood sugar to levels to those found in non-diabetic adults may reduce the rate of cardiovascular disease in patients with diabetes.

In the ADVANCE trial, which involves 20 countries worldwide including Canada, the intensive blood glucose lowering program aimed to reduce levels of hemoglobin A1c (a marker of long term blood glucose control) to ≤6.5%. Treatment included a sulfonylurea drug, gliclazide modified release, for all patients, and a number of other agents for those patients unable to reach target blood glucose levels. The ADVANCE trial was started in 2001 and patients were followed for an average of five years.

Because the A1c targets in ACCORD and ADVANCE are similar, and the intensive blood glucose control arm of ACCORD was stopped early, the ADVANCE mortality data was reviewed by the Data and Safety Monitoring Committee to determine if there was a similar excess risk of mortality. This committee advised that data did not provide any confirmation of the adverse mortality trend reported from ACCORD.

Final patient visits have been completed and the ADVANCE study data base is close to finalization. We expect to have definitive results soon, said Study Director, Dr. Anushka Patel, from The George Institute in Sydney, Australia. At this stage, the Data Monitoring and Safety Committee have reviewed results that are more than 99% complete, so we are confident that the interim findings are a reliable guide to the final results.

Final data from the ADVANCE trial is expected to be promising in terms of risk minimization but multiple analyses are required before conclusions can be drawn regarding the effects of intensive glucose control on patient outcomes. Additional d
'/>"/>

Contact: Nathalie Forgue
nathalie.forgue.chum@ssss.gouv.qc.ca
51-489-080-001-4342
University of Montreal
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Survival differences by race most apparent in advanced stages of breast cancer
2. Patients with Medicaid and those lacking insurance have higher risk of advanced laryngeal cancer
3. Advanced Age No Bar to Liver Transplant
4. Ovation further advances development pipeline with new phase III epilepsy study
5. Medical, technological advances prompt updating of nuclear medicine technologists scope of practice
6. Oncologists are critical in managing psychiatric disorders in patients with advanced cancer
7. Advanced technologies aim to transform the coaching of top athletes
8. Major grant advances UWs clinical and translational research enterprise
9. Mecklenburg EMS Introduces Most-Advanced Situational Training in America for Emergency Medical Personnel
10. Advanced Life Sciences Joins NASDAQ Capital Market
11. Photos: New Survey Shows Many Successful Quit Smoking Attempts Made Without Advance Planning
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2015)... The partners of Urgent Care of Westchester and ... Almendral as their chief provider for advanced beauty treatments. ... opened facility’s plan to offer all of Westchester County ... Almendral is a board certified physician who is trained ... techniques. Her areas of expertise include Botox, Dermal Fillers, ...
(Date:5/28/2015)... On Sunday, June 21, 2015, Colorado residents will ... honor the strength, passion and endurance of those facing ... of this sunrise-to-sunset event symbolizes the challenging journey of ... raise funds and awareness to advance the care, support ... are encouraged to create their own experience as they ...
(Date:5/28/2015)... Dr. Jenyons’ Medical Weight Loss & Rejuvenation ... looking to undergo its advanced Micro-Needling skin rejuvenating procedure. ... able to get a single Micro-Needling treatment with plasma, ... three-treatment package, which costs $1,800, the clinic will add ... Juanita Jenyons, M.D., says Dr. Jenyons’ Medical Weight Loss ...
(Date:5/28/2015)... 28, 2015 Medelis, Inc., a specialty ... the company in the role of president. , “ Bill ... the CRO industry,” said Larry Flanagan, Medelis’ CEO and co-founder. ... through our next phase of growth.” , Taaffe joined ... from nine employees to over 4,500 employees, achieving 12 consecutive ...
(Date:5/28/2015)... May 28, 2015 Altima Technologies, ... Device Library for documenting and diagramming data center ... for the following product lines: , Manufacturer ... 5500, Chatsworth Products N-Series TeraFrame Cabinet, Middle Atlantic ... Eclipse, Fore Systems ForeRunner, Marantz America MM Series, ...
Breaking Medicine News(10 mins):Health News:Bella Diosa Med Spa Welcomes Botox Specialist to Yonkers Community 2Health News:Dr. Jenyons’ Medical Weight Loss & Rejuvenation Center Now Offering Skin Treatment Specials 2Health News:Dr. Jenyons’ Medical Weight Loss & Rejuvenation Center Now Offering Skin Treatment Specials 3Health News:Bill Taaffe, Former President and CEO of ICON Clinical Research-US, Joins Medelis, a Specialty Oncology CRO, in the Role of President 2Health News:NetZoom™ Visio® Stencil Library Updates for EMC, Cisco, and Chatsworth Products 2
... New Delhi: The National AIDS Control Organization (NACO) has ... to provide free anti-retroviral treatment (ART). //The count of ... on the anvil. , ,These centers will support ... the services of exclusive doctors, counselors and laboratory technicians ...
... or get the consent of one or both parents before ... to a Florida State University law professor in Tallahassee, Fla. ... and Thomas Stratmann, professor of economics at George Mason University, ... of gonorrhea among teenage girls as a measure of risky ...
... reduce their risk of becoming obese children, even if ... a study led by a researcher at the University ... ,The findings contradict an earlier, smaller study that found ... diabetes had poor glucose tolerance, a precursor to diabetes, ...
... self-image as the “strong, silent type” and the stigma ... less likely than women to be referred to studies ... recognize and express symptoms of depression, according to clinicians ... UC Davis Department of Psychiatry and Behavioral Sciences. ...
... tennis elbow and a wait and watch approach may be ... Australian researchers tested this approach in one group of volunteers, ... ,A second group were given a local ... The final group received eight treatments of physiotherapy of 30 ...
... amphetamine abuse in the Asia-Pacific region has hit high levels ... problem threatening Asia that is this big is a problem ... Australia as is the security of Australia in terms of ... the United Nations Office of Drugs and Crime told AFP. ...
Cached Medicine News:Health News:Abortion Notification, Consent Laws Reduce Risky Teen Sex 2Health News:Breast-Feeding May Reduce Childhood Obesity 2Health News:Stereotypes Contribute to Older Men Seeking, Receiving Depression Care Less Frequently 2Health News:Stereotypes Contribute to Older Men Seeking, Receiving Depression Care Less Frequently 3Health News:Stereotypes Contribute to Older Men Seeking, Receiving Depression Care Less Frequently 4Health News:Steroids Ineffective In Tennis Elbow 2
(Date:5/28/2015)... May 28, 2015 Research ... addition of the "United States Medical Adhesives ... their offering.      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ... the United States is ... Medical device manufacturers across the US ...
(Date:5/28/2015)... May 28, 2015 Isis Pharmaceuticals, Inc. (NASDAQ: ... Therapeutics WebcastWhen: , Thursday, June 4 at 1:00 p.m. ... , Live on the Internet.  Simply log onto our ... during the live event, a replay of the webcast ... www.isispharm.com . ABOUT ISIS PHARMACEUTICALS, INC. Isis ...
(Date:5/28/2015)... Md. , May 28, 2015 ... it will be a supporting organization of the ... and sterilization in 2016. Johnson & ... series of high-profile superbug infections in endoscopes. J&J ... health issues between 1976 and 2003 on advances ...
Breaking Medicine Technology:United States Medical Adhesives Market Forecast and Opportunities, 2020 - New Medical Innovations with 3M, Henkel Adhesive Research, Ethicon and Cyberbond Dominating 2United States Medical Adhesives Market Forecast and Opportunities, 2020 - New Medical Innovations with 3M, Henkel Adhesive Research, Ethicon and Cyberbond Dominating 3Webcast Alert: Akcea Therapeutics Conference Call 2Webcast Alert: Akcea Therapeutics Conference Call 3PDA Announces Support for the Johnson & Johnson Kilmer Conference 2
... a clinical-stage biopharmaceutical company focused on the development of ... other inflammatory diseases, announced today that CEO Martin Driscoll ... during the annual BIO International Convention.  Mr. Driscoll,s presentation ... Walter E. Washington Convention Center in Washington, DC on ...
... June 22, 2011 Amended 13D for RepliGen ... Ronald L. Chez, a private investor. Mr. Ronald ... a private investor. RepliGen Corporation is a biopharmaceutical company ... drugs that deliver the benefits of protein therapies in the fields ...
Cached Medicine Technology:Asmacure Ltee to Present at the 2011 BIO Business Forum During the Annual BIO International Convention 2
Indications For Usage: ,Pediatric (recommended tidal volume 70-250ml), single patient use on anesthetized patients and respiratory care patients who require a breathing circuit. The product is intend...
Indications For Usage: ,Adult (recommended tidal volume >150ml), single patient use on anesthetized patients and respiratory care patients who require a breathing circuit. The product is intended to...
... The Portex® Thermovent® T helps provide protection ... It is small and extremely lightweight making it ... adults. With a high rate of heat and ... secretion retention., ,All HMEs and filters have ...
... helps provide protection to the exposed airway of ... lightweight making it ideal for active young children ... of heat and moisture recovery, it ensures patient ... and filters have ISO standard tapered ends to ...
Medicine Products: