Navigation Links
ADHD medicine affects the brain's reward system
Date:11/9/2012

d punishment

In the brain, dopamine contributes to series of processes that control our behaviour. Actions such as eating, winning a competition, having sex or taking a narcotic drug increase dopamine release. Scientists think that dopamine helps motivate us to repeat actions that have previously been associated with reward.

"Control mechanisms in the brain help keep the dopamine signal in balance so we can register the tiny deviations that signal reward and punishment. We discovered while trying to describe these control mechanisms that our model can be used to examine the influence of Ritalin, for example, on the signal. Suddenly we could see that different pathways of the reward system are affected to different degrees by the medicine, and we could calculate at what dosage different parts of the signal would be changed or destroyed," says Jakob Kisbye Dreyer.

Different dosage, different effect

Drugs such as Ritalin can have paradoxical effects: high dosage increases the patient's activity while low dosage reduces it. Therefore it can be a laborious process to find the right dosage for a patient.

"We can explain this double effect using our theory. The dopamine signal in the part of the brain that controls our motor behaviour is only affected at a higher dose that the dose usually prescribed for treatment. Also, our model shows that the threshold between a clinically effective dose and too high a dose is very low. That may explain why the small individual differences between patients have a big impact on treatment," says Jakob Kisbye Dreyer.

In the long term, the scientists hope that their new insight will help doctors determine the correct dose for each patient. The model can also help us understand what signals in the brain affect not only ADHD, but schizophrenia, Parkinson's disease and drug abuse as well.


'/>"/>
Contact: Postdoc Jakob Kisbye Dreyer
jakobdr@sund.ku.dk
45-60-80-95-51
University of Copenhagen
Source:Eurekalert

Page: 1 2

Related medicine news :

1. First targeted nanomedicine to enter human clinical studies
2. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
3. AFAR announces the 2012 Hartford Centers of Excellence in Geriatric Medicine awards
4. DNA Testing Finds Allergens, Toxins in Traditional Chinese Medicines
5. Not taking gastroprotective drugs prescribed with anti-inflammatory medicines
6. Nearly 1 in 4 grandparents store prescription medicines where children can easily find them
7. Wilderness Medicine founder offers health tips for summer season
8. Internal medicine physician specialists release policy paper on reforming Medicaid
9. Awards to 5 IU School of Medicine physicians address critical need for geriatricians
10. Annals of Internal Medicine tip sheet for May 8, 2012, online issue
11. New twist on ancient math problem could improve medicine, microelectronics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... 25, 2014 When head lice hits a ... a frenzy to get rid of it while keeping it ... Coral Gables now have the solution right in their neighborhood: ... location, Lice Troopers provides full spectrum head lice screening and ... area, including Sunset, Key Biscayne, Brickell, Coconut Grove, Kendall, Pinecrest ...
(Date:12/25/2014)... THURSDAY, Dec. 25, 2014 (HealthDay News) -- The risk ... the holidays, so you need to be extra cautious, ... Day, we see a significant increase in patients coming ... at the Suffolk County Volunteer Firefighters Burn Center of ... celebrations should be full of joy, but if not ...
(Date:12/25/2014)... HealthDay Reporter WEDNESDAY, Dec. ... on a "fountain of youth" drug that can delay the ... a new study suggests. Seniors received a significant boost ... a genetic signaling pathway linked to aging and immune function, ... The experimental medication, a version of the drug rapamycin, improved ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 “ SmileStix ” ... which features the latest and coolest mobile applications on the ... expert and host of NewsWatch, conducted the app review and ... to create personal stickers. , The old saying goes, “A ... lot of words that can describe a single image, because ...
(Date:12/25/2014)... CA (PRWEB) December 25, 2014 Each ... visits and 2 million hospital admissions across the nation ... Prevention ). The CDC’s National Hospital Ambulatory Medical ... through a survey conducted in 2010. They estimated that ... visits that resulted in a primary diagnosis of broken ...
Breaking Medicine News(10 mins):Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2Health News:Don't Let Burns Mar Your Holidays 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3Health News:An Application to Create Custom Stickers was Featured on NewsWatch Television on December 19, 2014 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 3Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 4
... Modern cancer care is critically dependent on imaging ... and guide their therapy or surgery. Molecular imaging ... characteristics of malignancies, tumor stage and therapeutical response, ... assess the tumor,s anatomical or morphologic features including ...
... markers were analyzed in 83 cases of colorectal ... chain reaction (PCR). PCR products were eletrophoresed on ... Genotype 3.7 software were used for loss of ... features, significant relationship was observed between LOH frequencies ...
... CHICAGO, Sept. 24 "The Lions are coming!,Look for them ... and Saturday, October 10 and 11 for Lions Candy Day, ... The face of Lionism was changed forever in Illinois in ... to "man" the street corners giving,away small plastic white cane ...
... to massage for relief, EVANSTON, Ill., Sept. 24 ... massage therapy for relaxation, according to the 12th,annual consumer ... survey found that 59 percent of Americans are,more stressed ... are the,top reasons Americans received their last massage. These ...
... Available on, http://www.flucliniclocator.org, Helps People Find Local ... The American Lung,Association is making it a ... shot,this season with the availability of its 2008-2009 ... influenza vaccination clinics is now,available at http://www.flucliniclocator.org ...
... UCSF scientists are among the 31 nationwide who ... National Institutes of Health. The awards are designed ... that could transform biomedical and behavioral science." , ... costs over five years, were awarded to Yuriy ...
Cached Medicine News:Health News:LOH analysis on 4q in sporadic colorectal carcinoma 2Health News:Lions Taking to the Street Corners! 2Health News:Massage Therapy Use Holds Steady, Despite Lagging Economy 2Health News:Massage Therapy Use Holds Steady, Despite Lagging Economy 3Health News:American Lung Association Joins Health Officials to Prevent the Spread of Influenza by Urging People to Get Vaccinated 2Health News:American Lung Association Joins Health Officials to Prevent the Spread of Influenza by Urging People to Get Vaccinated 3Health News:American Lung Association Joins Health Officials to Prevent the Spread of Influenza by Urging People to Get Vaccinated 4Health News:2 UCSF scientists recognized for transformative research 2Health News:2 UCSF scientists recognized for transformative research 3
(Date:12/24/2014)... Dec. 24, 2014  Diplomat Pharmacy, Inc. (NYSE: ... is proud to announce Jennifer Hagerman , Pharm.D., ... will take office as the president of the Michigan ... ceremony will take place Feb. 28, 2015, at the ... at the Renaissance Center in Detroit, Michigan ...
(Date:12/24/2014)... Dec. 23, 2014 PuraMed BioScience®, Inc., (OTC ... (OTC) medicinal and healthcare products, announced it received the ... a hemp-based, advanced headache relief product, for planned distribution ... Colorado , Washington State ... With the MigraPure H Advanced headache relief gel formulation ...
(Date:12/24/2014)... DIEGO , Dec. 23, 2014 ResMed (NYSE: ... significant patent infringement action against Chinese medical device manufacturer BMC ... (ITC) ruled today that BMC,s masks listed below infringe ResMed,s ... or selling these masks in the United States ... iVolve N2 nasal mask , Willow nasal pillows mask ...
Breaking Medicine Technology:Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 2PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 3ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: