Navigation Links
ADHD medicine affects the brain's reward system
Date:11/9/2012

d punishment

In the brain, dopamine contributes to series of processes that control our behaviour. Actions such as eating, winning a competition, having sex or taking a narcotic drug increase dopamine release. Scientists think that dopamine helps motivate us to repeat actions that have previously been associated with reward.

"Control mechanisms in the brain help keep the dopamine signal in balance so we can register the tiny deviations that signal reward and punishment. We discovered while trying to describe these control mechanisms that our model can be used to examine the influence of Ritalin, for example, on the signal. Suddenly we could see that different pathways of the reward system are affected to different degrees by the medicine, and we could calculate at what dosage different parts of the signal would be changed or destroyed," says Jakob Kisbye Dreyer.

Different dosage, different effect

Drugs such as Ritalin can have paradoxical effects: high dosage increases the patient's activity while low dosage reduces it. Therefore it can be a laborious process to find the right dosage for a patient.

"We can explain this double effect using our theory. The dopamine signal in the part of the brain that controls our motor behaviour is only affected at a higher dose that the dose usually prescribed for treatment. Also, our model shows that the threshold between a clinically effective dose and too high a dose is very low. That may explain why the small individual differences between patients have a big impact on treatment," says Jakob Kisbye Dreyer.

In the long term, the scientists hope that their new insight will help doctors determine the correct dose for each patient. The model can also help us understand what signals in the brain affect not only ADHD, but schizophrenia, Parkinson's disease and drug abuse as well.


'/>"/>
Contact: Postdoc Jakob Kisbye Dreyer
jakobdr@sund.ku.dk
45-60-80-95-51
University of Copenhagen
Source:Eurekalert

Page: 1 2

Related medicine news :

1. First targeted nanomedicine to enter human clinical studies
2. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
3. AFAR announces the 2012 Hartford Centers of Excellence in Geriatric Medicine awards
4. DNA Testing Finds Allergens, Toxins in Traditional Chinese Medicines
5. Not taking gastroprotective drugs prescribed with anti-inflammatory medicines
6. Nearly 1 in 4 grandparents store prescription medicines where children can easily find them
7. Wilderness Medicine founder offers health tips for summer season
8. Internal medicine physician specialists release policy paper on reforming Medicaid
9. Awards to 5 IU School of Medicine physicians address critical need for geriatricians
10. Annals of Internal Medicine tip sheet for May 8, 2012, online issue
11. New twist on ancient math problem could improve medicine, microelectronics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Thompson HealthDay Reporter THURSDAY, ... with HIV who was thought to be cured by immediate ... detectable levels of the AIDS-causing virus in her bloodstream, disappointed ... 4 years old, had remained virus-free even though she stopped ... had hoped her remission would open the door to a ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 The Europe Well ... market in Europe with analysis and revenue forecast. The well ... around $2.4 billion in 2013 to $3.4 billion by 2018, ... Browse through the TOC of the Europe Well Intervention Market ... This also provides a glimpse of the segmentation in the ...
(Date:7/11/2014)... News) -- Children who have emergency surgery on ... potentially even death than those who have weekday ... the Johns Hopkins researchers noted that the risk ... data on nearly 440,000 simple emergency surgeries that ... 22-year period. The surgeries are considered generally ...
(Date:7/11/2014)... According to a new market research ... Communication Technology (ZigBee, Z-Wave, Bluetooth, Wi-Fi, NFC, RFID), Application ... Transportation, Agriculture) & Geography - Global Trends & Forecasts ... Things market was worth $1029.5 Billion in 2013, and ... an estimated CAGR of 4.08% from 2014 to 2020. ...
(Date:7/11/2014)... PROVIDENCE, R.I. -- Researchers from The Miriam ... under age 65 have significantly higher rates of ... with mobility impairments were less likely to attempt ... quit-smoking treatments may not be sufficient for this ... online in advance of print in the ...
Breaking Medicine News(10 mins):Health News:Mississippi Girl Thought Cured of HIV Shows Signs of Infection 2Health News:Mississippi Girl Thought Cured of HIV Shows Signs of Infection 3Health News:Europe Well Intervention Services Market is Expected to Reach $3.4 Billion by 2018 - New Report by MicroMarket Monitor 2Health News:Europe Well Intervention Services Market is Expected to Reach $3.4 Billion by 2018 - New Report by MicroMarket Monitor 3Health News:Emergency Surgeries on Weekends Riskier for Kids: Study 2Health News:Internet of Things Technology & Application Market Worth $1423.09 Billion by 2020 – New Report by MarketsandMarkets 2Health News:Internet of Things Technology & Application Market Worth $1423.09 Billion by 2020 – New Report by MarketsandMarkets 3Health News:Internet of Things Technology & Application Market Worth $1423.09 Billion by 2020 – New Report by MarketsandMarkets 4Health News:Miriam Hospital study examines smoking prevalence 2
... The Libyan Department of Relief and Humanitarian ... a significant capability for medical disaster response in ... experts from the American-based company BLU-MED Response Systems ... University where members of Libyan Aid erected the ...
... March 3 Sysmex America, Inc., a leading ... today announced the availability of the Sysmex WAM ... middleware user facilities across the U.S. Sysmex WAM ... tool for new Sysmex WAM users and as ...
... soles of their feet and the palms of their hands ... some types of chemotherapy. Patients, family members also can feel ... Both share a need for quick answers or more detailed ... or unexpected symptoms. , A new section of the ...
... Oxygen Community Welcomes New Leaders Known for Patient Advocacy, ... The Council for Quality Respiratory Care (CQRC), an alliance ... care for nearly one half of the 1.5 million ... for improved quality of life, today praised President Obama,s ...
... FRANKLIN, Mass., March 3 PLC Systems Inc. (OTC Bulletin ... the news wire its financial results for the fourth quarter ... on Thursday, March 12, 2009. The company plans to host ... ET on that same day. The call may be joined ...
... as Possible , ALEXANDRIA, Va., March 3 The ... to know that hospice delivers the highest quality care ... coping with life-limiting illness. A recent article carried by ... Greg Bluestein, 03/02/09) carries a misinformed quote from an ...
Cached Medicine News:Health News:Libyan Aid Tests 50-Bed BLU-MED Deployable Field Hospital 2Health News:Sysmex America Introduces On Demand Middleware Training Tool 2Health News:Walther Cancer Foundation grant funds new IU Simon Cancer Center Web site section 2Health News:Council for Quality Respiratory Care Applauds President Obama's Appointments of Governor Sebelius, DeParle to Lead Health Care Efforts 2Health News:NHPCO Comments on Misleading Quote in Associated Press Article and Provides Helpful Information 2
(Date:1/15/2014)... , Jan. 15, 2014 Sono-Tek Corporation (OTC BB: ... ended November 30, 2013, compared to sales of $2,202,000 for ... Once again, this quarter has also shown growth over the ... first quarter of this fiscal year. Markets that experienced sales ...
(Date:1/15/2014)... SAN ANTONIO , Jan. 15, 2014 Most ... take, according to a recent online survey* sponsored by ... among the National Osteoporosis Foundation online support community, ... to take medication that comes in a form other ...
(Date:1/15/2014)... 2014 As health officials across the Midwest warn against ... in Michigan will offer free diagnostic ... Meijer pharmacists to administer tests and, in some cases, fill ... participating in the study. The Grand ...
Breaking Medicine Technology:Sono-Tek Announces Third Quarter Results 2Sono-Tek Announces Third Quarter Results 3Sono-Tek Announces Third Quarter Results 4Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3
... from Medtronic is changing the way clinicians ... their Medtronic CareLink Monitor and a standard ... information from their home or while traveling. ... have the ability to review device data ...
... Innova 3100 lets you perform exams from ... one room. With no compromises. An ideal ... a wide range of cardiovascular and interventional ... suited for a variety of vascular and ...
... Service provides clinically valuable, device-derived information ... failure to help specialty physicians discern ... are stable or deteriorating. For example, ... a Medtronic InSync Sentry™ CRT-D system ...
... Arginine vasopressin (AVP), also known as Antidiurectic ... and is transported via exonal flow to ... release. AVP secretion is regulated by changes ... that respond to alterations in blood volume ...
Medicine Products: