Navigation Links
ADH2 and ALDH2 are associated with esophageal cancer

As the seventh leading cause of cancer death worldwide, the occurrence of esophageal cancer varies by geographic area, ethnic group and gender. Esophageal cancer is thought to be triggered by a variety of environmental factors which interact with the host genome. Researchers have long been seeking the etiology of esophageal cancer. Many studies have been conducted on gene-environment interaction and gene polymorphisms for esophageal cancer.

One research article was published on November 21 in the World Journal of Gastroenterology to clarify the impact of alcohol dehydrogenase 2 (ADH2) and aldehyde dehydrogenase 2 (ALDH2) polymorphisms on esophageal cancer risk. This research team led by Dr. Chun-Xia Yang collected a cohort of 191 patients and 198 controls in Yanting, a rural county of Sichuan Province in China. Each participant completed a questionnaire and provided 1 mL of blood, which gave the team enough information about environmental and genetic factors on esophageal cancer.

This research reported that the ALDH2*1/*2 and ADH2*1 allele potentiate the carcinogenic effects of alcohol on the esophagus, and the two genotypes could modulate individual differences in alcohol-oxidizing capacity and drinking behavior. The acetaldehyde concentrations in the blood of individuals with inactive ALDH2*1/*2 is much higher than in those with active ALDH2 after drinking. ADH2*1 allele carriers tend to have experienced binge-drinking and withdrawal symptoms earlier in life. Accordingly, alcohol drinkers carrying ALDH2*1/*2 or ADH2*1 allele had a higher risk of developing esophageal cancer.

Furthermore, both the ADH2* 1 and ALDH2* 2 allele indicate a longer exposure to alcohol and highly-concentrated acetaldehyde, thus greatly increasing the individuals susceptibility to esophageal cancer.

The ALDH2*2 allele genotype studied by Dr. Chun-Xia Yang is prevalent in Asians. The results of this study suggest the need for further exploration on the relationship between genetics and esophageal cancer and will certainly be helpful in creating prevention strategies against esophageal cancer in China.


Contact: You-De Chang
World Journal of Gastroenterology

Related medicine news :

1. Use of Cellular Phones associated with Increased risk of Brain Tumors
2. Moderate Use of Analgesics - Not Associated With Kidney Dysfunction
3. Bayer Voluntarily Withdraws BAYCOL - A Drug Associated With 50 Deaths
4. Depression is associated with high risk for heart disease
5. Memory loss associated with microbes
6. Osteoporosis associated with Childhood Cancer
7. Toxin injections support stroke associated spasticity
8. Associated therapy for multiple myeloma
9. Associated scan for detecting ovarian cancer spread
10. Migraine & Juvenile stroke could be associated
11. Ginseng Associated with Pregnancy Risks
Post Your Comments:
(Date:10/13/2017)... Fort Worth, TX (PRWEB) , ... October 13, ... ... and financial planning agency serving communities in the greater Dallas, Miami, and Raleigh ... a young boy fighting to overcome a rare and deadly chromosome abnormality. , ...
(Date:10/13/2017)... ... October 13, 2017 , ... The ... to promote standards of excellence for the field of eating disorders, announces the ... – 25, 2018 in Orlando, Florida at the Omni Resort at ChampionsGate. ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Many families have ... many long-term care insurance companies have a waiver for care if the client has ... period, when the family pays for care, is often waived, so the benefits from ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... be giving viewers the lowdown on sciatica in a new episode of "Success ... focuses on current events and innovation and investigates each subject in-depth with passion ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco ... using cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated ... in breathing. Oral appliances can offer significant relief to about 75 percent of ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... --  Montrium , an industry leader in powerful ... Trial Master Files & Inspection Readiness Conference ( ... Services has selected eTMF Connect to ... a leading European contract research organization (CRO), will ... enable greater collaboration with sponsors, improve compliance and ...
(Date:9/19/2017)... Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, ... tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek , PhD, ...
(Date:9/12/2017)... NEW YORK , Sept. 12, 2017   EcoVadis , the ... chains, has published the first annual edition of its Global CSR Risk ... 20,400 companies evaluated by EcoVadis, based on Scorecard Ratings that analyzed nearly ... ... Performance Index ...
Breaking Medicine Technology: