Navigation Links
ADH2 and ALDH2 are associated with esophageal cancer
Date:10/31/2007

As the seventh leading cause of cancer death worldwide, the occurrence of esophageal cancer varies by geographic area, ethnic group and gender. Esophageal cancer is thought to be triggered by a variety of environmental factors which interact with the host genome. Researchers have long been seeking the etiology of esophageal cancer. Many studies have been conducted on gene-environment interaction and gene polymorphisms for esophageal cancer.

One research article was published on November 21 in the World Journal of Gastroenterology to clarify the impact of alcohol dehydrogenase 2 (ADH2) and aldehyde dehydrogenase 2 (ALDH2) polymorphisms on esophageal cancer risk. This research team led by Dr. Chun-Xia Yang collected a cohort of 191 patients and 198 controls in Yanting, a rural county of Sichuan Province in China. Each participant completed a questionnaire and provided 1 mL of blood, which gave the team enough information about environmental and genetic factors on esophageal cancer.

This research reported that the ALDH2*1/*2 and ADH2*1 allele potentiate the carcinogenic effects of alcohol on the esophagus, and the two genotypes could modulate individual differences in alcohol-oxidizing capacity and drinking behavior. The acetaldehyde concentrations in the blood of individuals with inactive ALDH2*1/*2 is much higher than in those with active ALDH2 after drinking. ADH2*1 allele carriers tend to have experienced binge-drinking and withdrawal symptoms earlier in life. Accordingly, alcohol drinkers carrying ALDH2*1/*2 or ADH2*1 allele had a higher risk of developing esophageal cancer.

Furthermore, both the ADH2* 1 and ALDH2* 2 allele indicate a longer exposure to alcohol and highly-concentrated acetaldehyde, thus greatly increasing the individuals susceptibility to esophageal cancer.

The ALDH2*2 allele genotype studied by Dr. Chun-Xia Yang is prevalent in Asians. The results of this study suggest the need for further exploration on the relationship between genetics and esophageal cancer and will certainly be helpful in creating prevention strategies against esophageal cancer in China.


'/>"/>

Contact: You-De Chang
y.d.chang@wjgnet.com
86-108-538-1892
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Use of Cellular Phones associated with Increased risk of Brain Tumors
2. Moderate Use of Analgesics - Not Associated With Kidney Dysfunction
3. Bayer Voluntarily Withdraws BAYCOL - A Drug Associated With 50 Deaths
4. Depression is associated with high risk for heart disease
5. Memory loss associated with microbes
6. Osteoporosis associated with Childhood Cancer
7. Toxin injections support stroke associated spasticity
8. Associated therapy for multiple myeloma
9. Associated scan for detecting ovarian cancer spread
10. Migraine & Juvenile stroke could be associated
11. Ginseng Associated with Pregnancy Risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/18/2017)... (PRWEB) , ... February 18, 2017 , ... ... today provides the latest information and contact points to easily connect elderly veterans ... care, assisted living, and elder-care funding. It also conveys material on this year's ...
(Date:2/17/2017)... ... February 17, 2017 , ... ... for the electronic prescribing of controlled and non-controlled substances plus the ability to ... pharmacies in the United States now accept electronic prescriptions, according to the Office ...
(Date:2/17/2017)... Church, VA (PRWEB) , ... February 17, 2017 ... ... Implementing the Steps to Prevent a Warning Letter, **An FDAnews Webinar**, Feb. 23, ... , Do manufacturers distinguish between corrective action (CA) and preventive action (PA)? ...
(Date:2/17/2017)... Austin, Tx (PRWEB) , ... February 17, 2017 ... ... of revenue cycle management services, announced today that Karen Pilley has been promoted ... expenses is critical in today’s shifting healthcare paradigm – a shift that demands ...
(Date:2/17/2017)... ... February 17, 2017 , ... Like most hospitals across the nation, Onslow ... part by the Hospital Readmission Reduction Program (HRRP), the return of a patient to ... hospitals across the nation. While many providers are struggling to leverage limited resources and ...
Breaking Medicine News(10 mins):
(Date:2/16/2017)... (NYSE: DVA ) today announced results for the ... Net income attributable to DaVita Inc. for the quarter and ... per share and $880 million, or $4.29 per share, respectively. ... for the quarter and year ended December 31, 2016, excluding ... per share, and $789 million, or $3.85 per share, respectively. ...
(Date:2/16/2017)... ST. LOUIS , Feb. 16, 2017  Express Scripts (NASDAQ: ... one of the World,s Most Admired Companies within the Health Care: ... to be named one of the World,s Most Admired Companies," said ... is driven by the commitment and passion of our 26,000 employees ... people we serve." ...
(Date:2/16/2017)... Research and Markets has announced the addition of the "Global ... Cancer Type, Technology - Forecast to 2025" report to their ... The ... a CAGR of around 28.6% over the next decade to reach ... the prominent trends that the market is witnessing include increasing demand ...
Breaking Medicine Technology: