Navigation Links
ACE inhibitors may increase risk of recurrence in breast cancer survivors
Date:4/20/2011

ACE inhibitors, commonly used to control high blood pressure and heart failure in women, may be associated with an increased risk of recurrence in women who have had breast cancer, according to a study by researchers at UCLA's Jonsson Comprehensive Cancer Center.

Beta blockers, used to control high blood pressure and cardiac arrhythmias, appear to have a protective effect, helping to prevent recurrence. When used together, beta blockers appear to help ameliorate the negative affect of ACE inhibitors, said Dr. Patricia Ganz, director of cancer prevention and control research at UCLA's Jonsson Cancer Center and first author of the study.

Ganz characterized the results of the retrospective analysis done using data from the Life After Cancer Epidemiology (LACE) study, which includes 1,779 Kaiser patients diagnosed with early stage breast cancer, as "hypothesis-generating only." She underscored that the results need further corroboration in other, larger clinical data bases.

However, the surprising negative effect of the ACE inhibitors on chances for recurrence is, at the least, cause for caution.

"The message from this is we have to be aware of other chronic health problems and medications that patients take after their diagnosis of breast cancer," said Ganz, an international expert in the fields of quality of life after cancer and cancer survivorship. "We are learning that some medications, while they may be very helpful for treating cardiovascular disease and hypertension, may have an adverse effect on breast cancer survivors."

In the study, just published online in the journal Breast Cancer Research and Treatment, Ganz speculated that ACE inhibitors and beta blockers may work differently in the breast cancer microenvironment, affecting different pathways of inflammation, and that may be the key to their disparate impact on breast cancer recurrence.

It's long been thought that inflammation fuels c
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles Health Sciences
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Afatinib benefits lung cancer patients whose cancer progressed after treatment with EGFR inhibitors
2. JAK inhibitors producing significant response in myelofibrosis patients
3. Current smokers with early rheumatoid arthritis less responsive to TNF inhibitors, methotrexate
4. Combining 2 peptide inhibitors might block tumor growth
5. Combining MEK and PI3K inhibitors appears encouraging in a safety study with early signs of anti-tumor activity
6. Governor Rendell Proposes Budget With No Tax Increase, More Money for Public Schools, Strategy for Jobs, Plan to Address Future Deficits
7. Soft drinks may increase risk of pancreatic cancer
8. New Report: $1 Cigarette Tax Increase Would Raise $418.8 Million for Texas and Cut Youth Smoking
9. New Report: $1 Cigarette Tax Increase Would Raise $18.6 Million for Montana and Cut Youth Smoking
10. New Report: $1 Cigarette Tax Increase Would Raise $24.8 Million for Wyoming and Cut Youth Smoking
11. New Report: $1 Cigarette Tax Increase Would Raise $43.3 Million for Utah and Cut Youth Smoking
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... 2014 Eagerly embracing intended parents around ... and now offers the top male infertility programs — ... The fertility network of IVFinMexico.com continues to ... reproductive care, female and male infertility, advanced research and ... standards so eminently set by company CEO and Founder ...
(Date:8/22/2014)... August 22, 2014 The improved access ... specifically in the developing world, has led to the ... number of deaths due to AIDS globally. However, despite ... number of new patients becoming affected by the virus ... being undertaken by all related organisations and stakeholders, by ...
(Date:8/22/2014)... NJ. August 22, 2014. A new study ... persons with multiple sclerosis (MS) may be able ... The study was epublished ahead of print on ... Helen Genova, Hali Griswold, Nancy D. Chiaravalloti & ... persons with multiple sclerosis doi: 10.3233/NRE-141113). Self-awareness is ...
(Date:8/22/2014)... open blockages in the kidney arteries may benefit ... clinical trials, according to new recommendations for renal ... Interventions today by the Society for Cardiovascular ... Medical Center,s Sahil Parikh, MD, Director, Interventional Cardiology ... Reserve University School of Medicine was the lead ...
(Date:8/22/2014)... August 22, 2014 Home Care ... in-home care for seniors, is proud to announce the ... The upcoming webinar will feature Dr. Suzanne Steinbaum, attending ... Hill Hospital in New York City, National Spokesperson for ... The webinar will cover the issues surrounding women and ...
Breaking Medicine News(10 mins):Health News:Mexico Now Offers Top Program for Couples Suffering from Male Infertility 2Health News:Mexico Now Offers Top Program for Couples Suffering from Male Infertility 3Health News:Mexico Now Offers Top Program for Couples Suffering from Male Infertility 4Health News:Worldwide HIV Infection Drug Market Examined in New Kuick Research Report Published at MarketPublishers.com 2Health News:Worldwide HIV Infection Drug Market Examined in New Kuick Research Report Published at MarketPublishers.com 3Health News:Kessler Foundation study of self-awareness in MS has implications for rehabilitation 2Health News:UH Case Medical Center's Dr. Parikh authors SCAI paper on renal artery stenosis treatment 2Health News:UH Case Medical Center's Dr. Parikh authors SCAI paper on renal artery stenosis treatment 3Health News:Home Care Assistance of Centennial to Host Webinar on Heart Health, Featuring Dr. Suzanne Steinbaum 2Health News:Home Care Assistance of Centennial to Host Webinar on Heart Health, Featuring Dr. Suzanne Steinbaum 3
... Statins, a class of drugs used to lower cholesterol levels, ... study from Tel Aviv University has now found that the ... almost 40%. "Doctors have known for some time ... have against cataracts," says Dr. Gabriel Chodick of the Department ...
... , WASHINGTON , Feb. 9 ... and Deliver: Sex, Health and Young People in the ... children,s health, the importance of parents and the moral ... , (Logo:   http://www.newscom.com/cgi-bin/prnh/20080930/FRCLOGO  ) , The report ...
... genetic and clinical data for nearly 800 patients with non-small ... are associated with age and sex specific patterns of increased ... February 10 issue of JAMA . The five-year ... and it remains the leading cause of cancer-related death in ...
... life stress could be a risk factor for cardiovascular ... life stress increases sensitivity to a hormone known to ... in adult life," said Dr. Jennifer Pollock, biochemist in ... Georgia and corresponding author on the study published online ...
... ... increases patient safety through accuracy and timeliness , ... (PRWEB) February 9, 2010 -- ... announced today that the University of Virginia Health System Medical Laboratories, in Charlottesville, ...
... hospitals more likely to insert them , TUESDAY, Feb. 9 ... up to make a profit are more likely to use ... the practice does not prolong life or help with bed ... about feeding tubes are more about which hospital you go ...
Cached Medicine News:Health News:A common cholesterol drug fights cataracts, too 2Health News:Family Research Council: Planned Parenthood Report Oversexualizes Ten-Year-Olds, Undermines Parental Authority 2Health News:Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer 2Health News:Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer 3Health News:Early life stress may predict cardiovascular disease 2Health News:University of Virginia Health System Medical Laboratories Selects Sunquest's Specimen Collection Solution 2Health News:University of Virginia Health System Medical Laboratories Selects Sunquest's Specimen Collection Solution 3Health News:Too Many With End-Stage Dementia Get Feeding Tubes 2Health News:Too Many With End-Stage Dementia Get Feeding Tubes 3
(Date:8/21/2014)... 2014 Nektar Therapeutics (NASDAQ: ... positive results from its Phase 3 pivotal clinical ... recombinant factor VIII (rFVIII) treatment for hemophilia A ... its primary endpoint in reducing annualized bleed rates ... on-demand arm. Top-line results from the ...
(Date:8/21/2014)... , Aug. 21, 2014  Publicis Groupe ... Hartley , Managing Partner and Healthcare Industry Group Leader, ... 100, which recognizes the most inspiring people in the ... leaders in research and development, marketing, technology, creativity, strategy ... in 2006 as a partner in its leading Rosetta ...
(Date:8/21/2014)... BURLINGTON, Mass. , Aug. 21, 2014 /PRNewswire/ ... of COPD,  physicians in Brazil ... to follow clinical guidelines and commonly prescribe long-acting ... regimens, although they do so within current severe ... combinations (FDCs) that are expected to launch in ...
Breaking Medicine Technology:Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 2Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 3Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 4Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 5Shannon Hartley Shines in PharmaVOICE 100 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 3
... Anpath Group, Inc.,(OTC Bulletin Board: ANPG), reported ... announced the selection of its,disinfectant, EnviroTru(TM) for ... (Metro). EnviroTru(TM) is a multi-purpose disinfectant ... also meets EPA requirements for,Toxicity Category IV ...
... of statins treated for 3 months with 200 mg/week mipomersen experienced ... continues to support mipomersen,s ... safety profile,- Isis hosting Analyst & Investor Day today - webcast live at 9:00 ... at http://www.isispharm.com , ...
Cached Medicine Technology:Anpath Group, Inc. Announces Selection of its Disinfectant by the Washington Metropolitan Area Transit Authority (Metro) 2Anpath Group, Inc. Announces Selection of its Disinfectant by the Washington Metropolitan Area Transit Authority (Metro) 3Isis Reports New Data for Mipomersen in Routine High Cholesterol Patients and Provides Cumulative Safety Summary 2Isis Reports New Data for Mipomersen in Routine High Cholesterol Patients and Provides Cumulative Safety Summary 3Isis Reports New Data for Mipomersen in Routine High Cholesterol Patients and Provides Cumulative Safety Summary 4Isis Reports New Data for Mipomersen in Routine High Cholesterol Patients and Provides Cumulative Safety Summary 5Isis Reports New Data for Mipomersen in Routine High Cholesterol Patients and Provides Cumulative Safety Summary 6Isis Reports New Data for Mipomersen in Routine High Cholesterol Patients and Provides Cumulative Safety Summary 7
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: