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ACCORD: Intensive BP, combined lipid therapies do not help adults with diabetes
Date:3/14/2010

n therapy with a fibrate and a statin to reduce cardiovascular disease in most high-risk adults with type 2 diabetes," said lead author Henry N. Ginsberg, M.D., director of the Irving Institute for Clinical and Translational Research at Columbia University College of Physicians and Surgeons, New York City. "Although our analysis suggests that certain patients may benefit from combination therapy, this study provides important information that should spare many people with diabetes unneeded therapy with fibrates."

"The lack of benefit from fibrates should not obscure the proven value of statins in preventing cardiovascular disease, which is well established from earlier studies," Ginsberg added. "Patients should discuss with their health care provider the implications of this research for their lipid therapy management."

An estimated 24 million Americans have diabetes, which is the seventh leading cause of death in the United States. Adults with type 2 diabetes are two to four times more likely than adults without diabetes to die from heart disease, and 65 percent of deaths in people with diabetes are from cardiovascular causes.

"These new ACCORD results indicate that we do not generally need to treat even more intensively than standard practice," said Denise G. Simons-Morton, M.D., Ph.D., co-author and former NHLBI project officer for ACCORD. Simons-Morton now directs the NHLBI's Division for the Application of Research Discoveries. "The treatment strategies used in the ACCORD standard control groups have previously been shown to be effective. So the findings in no way detract from the important point that controlling blood pressure and LDL cholesterol levels reduce cardiovascular risk not only in patients with diabetes, but in all patients with elevated levels."

The researchers caution that the results from the ACCORD clinical trial might not apply to patients who are at lower risk of cardiovascular disease than the ACCORD
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Contact: NHLBI Communications Office
nhlbi_news@nhlbi.nih.gov
301-496-4236
NIH/National Heart, Lung and Blood Institute
Source:Eurekalert

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