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AAI honors Chen Dong for breakthrough T lymphocyte research
Date:4/16/2009

ymposia gather top experts across disciplines to generate new ideas, exchange information and accelerate development of beneficial scientific applications.

Unleashing IL-17 on cancer

While Dong's research has been crucial to launching a new attack on autoimmune diseases, he's exploring one instance where autoimmunity would be desirable - when it's turned against cancer.

"There's always an immune response to tumors, but it's not strong enough," Dong said. "You need the right type of response. If you can help immune cells target cancer cells, it would be very beneficial." Preliminary data in a mouse model of autoimmunity against cancer are "very encouraging."

Dong directs the new Center for Inflammation and Cancer at M. D. Anderson, whose mission is to understand and improve the good inflammatory responses to cancer and dampen the chronic "bad" inflammation associated with many tumors.

"There are always good Th17 cells and bad Th17 cells. Everything is designed for a purpose. To little of that or too much of that is always the problem," Dong said.

Dr. Dong has made a host of important contributions to the competitive fields of co-stimulation and peripheral T cell differentiation, most recently in the description of the inflammatory Th17 cell subset. This award recognizes Dr. Dong, already a leader in his field at an early stage of his career, for both his impressive accomplishments to date and for his clear promise of continued success in the future.


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Contact: Scott Merville
smerville@mdanderson.org
713-516-4855
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

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