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AACR and Landon Foundation support the next generation of researchers with INNOVATOR Awards
Date:3/25/2011

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Huse's project is Personalizing PI3K/AKT pathway inhibitor therapy in malignant glioma. The PI3K/AKT signaling network has been repeatedly implicated in the pathogenesis of malignant glioma and represents a promising therapeutic target. However, the extent to which PI3K/AKT pathway activity fluctuates across the molecularly heterogeneous landscape of malignant glioma has not been established. Moreover, the relevance of such variability to pharmaceutical inhibition and treatment responsiveness is unclear.

Huse will address these questions using an innovative approach centered on the direct analysis of human glioma tissue. Using a panel of validated immunohistochemical, genomic, and transcriptional methods, he will perform extensive molecular profiling on more than 200 samples from the Memorial Sloan-Kettering Cancer Center Department of Pathology.

In doing so, he will establish connections between PI3K/AKT pathway activity, glioma-relevant genomic anomalies and recently established molecular subclasses. He will also directly translate findings to patient care by performing correlative molecular analysis for clinical trials with PI3K/AKT pathway inhibitors. Huse's goals are grounded in the development and application of the molecular pathology infrastructure necessary for personalized care advancement in neuro-oncology.


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Contact: Michele Sharp
Michele.Sharp@aacr.org
267-646-0622
American Association for Cancer Research
Source:Eurekalert

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