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AACR and Landon Foundation support the next generation of researchers with INNOVATOR Awards
Date:3/25/2011

ncreased the biologic and health care factors associated with cervical cancer. This has been seen most dramatically in sub-Saharan African countries such as Kenya, where cervical cancer is the most common cancer killer among women. Novel testing and treatment strategies that can be carried out in low-resource settings are urgently needed, especially among the growing population of women with HIV.

Testing for protein biomarkers expressed in the presence of cervical dysplasia has shown the potential to increase accuracy of detection of cervical intraepithelial neoplasia (CIN). One such protein, p16INK4a, has been identified as a biomarker with high sensitivity and specificity for CIN. Huchko's research team is in the final phase of a pilot study to test the feasibility of a 16INK4a biochemical assay collected from a cervical swab among women with HIV in western Kenya.

If shown to have a high specificity and sensitivity for CIN, a biochemical assay could be developed as of a point-of-care screening test, which would be ideal for a low-resource setting. This is the first study examining the performance of p16INK4a in women with HIV and the first to look at the performance of the biochemical assay in a low-resource setting.

Huchko will perform a validation trial to assess the capacity of a clinical laboratory in an outpatient clinic in western Kenya to independently analyze the p16INK4a specimens. In addition, she will use the cut-off values determined in the pilot study to evaluate the sensitivity and specificity of the p16INK4a biochemical assay to screen for CIN among women with HIV. This research could exponentially increase options for cervical cancer screening in low-resource settings and add another choice for screening women in all parts of the world.

2011 Landon Foundation-AACR INNOVATOR Award for International Collaboration in Cancer Research

Rebbeck's project, African Centers of Excellence in prostate can
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Contact: Michele Sharp
Michele.Sharp@aacr.org
267-646-0622
American Association for Cancer Research
Source:Eurekalert

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