Navigation Links
A versatile mouse that can teach us about many diseases and drugs
Date:3/13/2014

as been published in the prestigious journal Cell Reports.

"The great thing about this mouse is its flexibility and potential for looking at a broad range of diseases and molecular targets," said Dr Paul Timpson.

"It allows us to watch and map, in real time, parts of a cell or organ where Rac is active and driving invasion. In cancers, a lot of blue indicates an aggressive tumour that is in the process of spreading."

"You can literally watch parts of a tumour turn from blue to yellow as a drug hits its target. This can be an hour or more after the drug is administered, and the effect can wane quickly or slowly. Drug companies need to know these details - specifically how much, how often and how long to administer drugs."

Dr Heidi Welch is very modest about her role in creating the mouse, viewing it mostly as a tool that will help other scientists to understand Rac and work out how to stop cancer cells from moving.

"The credit must go to Professor Miki Matsuda, the genius who invented the biosensor in the first place 12 years ago," she said.

"He made his discovery freely available to the scientific community, and has been very open about his findings since."

"Miki Matsuda was super-helpful in suggesting the expression levels we should be looking for, and in recommending the exact biosensor we should use, out of many he developed. He was superb."

According to Welch, competition is growing rapidly in this area, with Matsuda himself making biosensor mice for a variety of target molecules.


'/>"/>

Contact: Alison Heather
a.heather@garvan.org.au
61-292-958-128
Garvan Institute of Medical Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Versatile microRNAs choke off cancer blood supply, suppress metastasis
2. Blade Runner Golf Announces a Tour Model Chipper That Is Versatile from 7 Iron Distances and Provides Success for Any Players Skill Level
3. Mouse Study Hints at New Path for Diabetes Treatment
4. This mousetrap may save lives
5. Its Not Just What You Eat, Its When You Eat, Mouse Study Finds
6. Belly Membrane May Regulate Immune System, Mouse Study Finds
7. Mouse Study Suggests Certain Fats Could Trigger Crohns, Colitis
8. New mouse model helps explain gene discovery in congenital heart disease
9. TB treatment paradox: Mouse studies show bodys own response helps TB bacteria survive
10. Scientists develop mouse model that could lead to new therapies for liver cancer
11. Mouse With Human-Like Immune System Could Advance AIDS Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... NY (PRWEB) , ... September 01, 2015 , ... ... non-profit organization devoted exclusively to funding innovative lymphoma research and serving the lymphoma ... – today announced its annual Light it Red for Lymphoma awareness initiative, the ...
(Date:9/1/2015)... ... September 01, 2015 , ... Philanthropic giving in the U.S. has been stuck ... Money for Good 2015, released today by Camber Collective, goes to the root of ... mobilize up to $22B in new philanthropic giving and shift $25B that’s already being ...
(Date:9/1/2015)... ... September 01, 2015 , ... Consumers overwhelmingly prefer to ... Dermatologic Surgery, according to a new survey that also offers insight on why ... Procedures – which reflects views on cosmetic medical treatments and ratings for 10 ...
(Date:9/1/2015)... ... 01, 2015 , ... Virginia entrepreneur Marcella Ellis, CEO and ... her firm’s success in the hair care and distribution industry through her combination ... will be providing “Look and learn” live demonstrations, as well as promoting her ...
(Date:9/1/2015)... ... ... The Jerry Segal Classic to benefit the patients of Magee Rehabilitation Hospital returns ... Hill, PA. Over the past 26 years, the Classic, organized by the Friends of ... support patients and their families during their time at Magee Rehabilitation Hospital. , ...
Breaking Medicine News(10 mins):Health News:Lymphoma Research Foundation Recognizes National Blood Cancer Awareness Month with Light it Red for Lymphoma Campaign 2Health News:Lymphoma Research Foundation Recognizes National Blood Cancer Awareness Month with Light it Red for Lymphoma Campaign 3Health News:Camber Collective Releases Money for Good 2015 - Revealing Root Causes to Why Charitable Giving Has Been Stuck at 2% GDP Since the 70s 2Health News:Camber Collective Releases Money for Good 2015 - Revealing Root Causes to Why Charitable Giving Has Been Stuck at 2% GDP Since the 70s 3Health News:Survey: Consumers Prefer ASDS Members 2Health News:Survey: Consumers Prefer ASDS Members 3Health News:Beauty Entrepreneur creates hair extension smart machine and mobile app inspired by UBER technology 2Health News:The 26th Jerry Segal Classic Returns to Benefit Patients of Magee Rehabilitation Hospital 2Health News:The 26th Jerry Segal Classic Returns to Benefit Patients of Magee Rehabilitation Hospital 3
... babies each day for hearing tests so that all parents ... New-born Hearing Screening // Programme will screen for hearing defects ... ,"Over 1,000 babies are born each year in ... ears," said Professor Adrian Davis, director of the screening programme. ...
... of Madhya Pradesh, which has been facing the death of ... has alerted the authorities, who in turn has started investigating ... ,Suraj Damor, the district magistrate of Burhanpur, said 80 ... ,Other reports, however, said some 400 chickens had died ...
... tobacco comes a substitute by researchers. // ,According ... at The University of Auckland's School of Population Health Smokers people ... they have is to adopt replacement nicotine patches or gum in ... funded by the Health Research Council and National Heart Foundation. ...
... has claimed the lives of two children in Mumbai and ... treated at various hospitals. // Health authorities said that more ... people who are undergoing treatment. ,Around 50 people ... the infection was detected. "At the last count, 90 people ...
... with bated breath to hear the announcement from Health Net ... what it has in store for those who wish to ... States. // ,The company has novel schemes on ... little as $75 a month, paid directly by individuals and ...
... the University Of Minnesota Medical School in Minneapolis said that ... memory loss. // ,This could be a new ... The team of scientists used genetically engineered mice that suffered ... ,Statistics show that about 12 million people worldwide suffer from ...
Cached Medicine News:Health News:Bird Flu Fear Grips Madhya Pradesh 2Health News:A great hope for quitters of smoking by researchers 2
(Date:9/1/2015)... 1, 2015 The global ... basis of sectors, products & services and application. And ... with the increasing demand of advanced drugs for ... propel the growth for bioinformatics market. The implementation ... is known as bioinformatics. Decreasing cost of DNA ...
(Date:9/1/2015)... DUBLIN , Aug. 31, 2015 ... the addition of the "Introduction to Veterinary ... to their offering. This course ... a good introduction to those concerned with Veterinary ... experienced personnel who reqire a better understanding of ...
(Date:9/1/2015)... , Sept. 1, 2015  Abbott (NYSE: ABT ... a multi-center, randomized trial comparing the safety and effectiveness ... ® , Abbott,s market-leading, permanent drug eluting stent. ... Japan and enrolled 400 people with ... disease. The results will be featured at a late-breaking ...
Breaking Medicine Technology:Global Bioinformatics Market Valued at Over $1.3 Billion in 2013 and is Expected to Grow at CAGR of 20.3% From 2014 to 2020: Hexa Research 2Global Bioinformatics Market Valued at Over $1.3 Billion in 2013 and is Expected to Grow at CAGR of 20.3% From 2014 to 2020: Hexa Research 3Global Bioinformatics Market Valued at Over $1.3 Billion in 2013 and is Expected to Grow at CAGR of 20.3% From 2014 to 2020: Hexa Research 4Introduction to Veterinary Pharmacovigilance Seminar (London, UK - September 23-24) 2Abbott Announces Positive Results of Its Naturally Dissolving Stent from ABSORB Japan Study 2Abbott Announces Positive Results of Its Naturally Dissolving Stent from ABSORB Japan Study 3Abbott Announces Positive Results of Its Naturally Dissolving Stent from ABSORB Japan Study 4
... has released an updated AutoLabel solution with enhanced customized ... virtually 100% of medications have a scan-ready bar code ... AutoLabel is a complete barcoding solution that provides color-coded ... improve patient safety at the bedside. New features include ...
... ("CTI") (NASDAQ and MTA: CTIC) announced that final results ... relapsed or refractory acute myeloid leukemia ("AML") was selected ... of Hematology ("ASH") Annual Meeting, which will be held ... Jorge Cortes, M.D., of The University of ...
Cached Medicine Technology:Talyst Updates Its AutoLabel® Solution 2Tosedostat OPAL Study Final Results Selected for Oral Presentation at the 2011 American Society of Hematology (ASH) Annual Meeting 2Tosedostat OPAL Study Final Results Selected for Oral Presentation at the 2011 American Society of Hematology (ASH) Annual Meeting 3Tosedostat OPAL Study Final Results Selected for Oral Presentation at the 2011 American Society of Hematology (ASH) Annual Meeting 4
... ergonomic chairs with concave seats ... support • Select options like ... and glides. • BTT/1P chairs ... environments: industry, education, laboratory, clean ...
... with concave seats and standard-sized ... Select options like seats, backrests, ... • BTT/1P chairs are recommended ... education, laboratory, clean room, static ...
... chairs with concave seats and large ... options like seats, backrests, armrests, and ... BE Series for top performance in ... education, laboratory, clean room, static control, ...
... ergonomic chairs with concave seats and ... Select options like seats, backrests, armrests, ... the BE Series for top performance ... industry, education, laboratory, clean room, static ...
Medicine Products: