Navigation Links
A tricky tumor virus
Date:1/17/2008

Epstein-Barr virus (EBV) is a human-pathogenic virus which belongs to the herpes virus family. Almost every adult carries EBV inside. With an infestation rate of more than 90 %, EBV is one of the most successful human viruses. Its viral genome consists of double-stranded DNA, and it is one of the few known viruses which cause cancer in humans under certain circumstances. EBV-associated cancers include lymphomas (cancer of the lymph nodes), nasopharyngeal carcinoma and gastric cancer.

A protein encoded by the virus, the latent membrane protein 1 (LMP1), is required for the uncontrolled proliferation of EBV-infected cells and, thus, the formation of cancer. Arnd Kieser and his team are studying the molecular mode of action of this EBV protein. LMP1 is a membrane-bound oncoprotein that binds certain signal molecules of its host cell and thereby critically contributes to the oncogenic transformation of the cells. One of these signal proteins is the factor TRADD. TRADD stands for TNF-receptor 1-associated death domain protein. The scientists used TRADD knockout cell lines which they had established by removing the TRADD gene from the genome of human B-cells in order to demonstrate that TRADD is an essential factor for LMP1 function. They found that in the absence of TRADD, LMP1 can no longer activate a cellular communication (also called: signal transduction) pathway which is crucial for cell transformation. However, TRADD's normal function within the cell includes the induction of programmed cell death which would be fatal for the virus. In fact, the scientists made the surprising observation that TRADD can no longer induce apoptosis if it is activated by the viral protein LMP1.

How does Epstein-Barr virus manage to switch off the apoptosis function of TRADD? Kieser and his colleagues discovered that the LMP1 protein possesses a unique TRADD binding domain which dictates an unusual TRADD interaction and prevents TRADD from transmitting cell deat
'/>"/>

Contact: Dr. Arnd Kieser
a.kieser@helmholtz-muenchen.de
0049-897-099-535
GSF - National Research Center for Environment and Health
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Findings point to molecular Achilles heel for half of breast cancer tumors
2. Transplant Drug Shrinks Tumors in Women With Rare Lung Disease
3. High-energy ultrasound sharpens view of liver tumors
4. Forever young: Differentiation blocked in tumor stem cells
5. Some Immature Brain Cells May Promote Tumors
6. Hormone may be new drug target for preventing lymphedema, tumor spread
7. Area Around Breast Tumor May Predict Cancers Spread
8. Microchip Spots Stray Tumor Cells in the Bloodstream
9. Microchip-based device can detect rare tumor cells in bloodstream
10. Even Tiny Breast Tumors May Need Aggressive Treatment
11. Even tiny breast tumors can be aggressive and may require maximum therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2014)... nearly half of all injuries aboard commercial freezer-trawlers and ... operating off the coast of Alaska, new research from ... and others aboard the two types of vessels could ... methods used in the study could help identify and ... fishing, said researcher Devin Lucas. His findings were published ...
(Date:4/15/2014)... Diego School of Medicine have identified a mechanism that ... liver disease and why the virus is able to ... The hard-to-kill pathogen, which infects an estimated 200 million ... the mitochondria dismantling the cell,s innate ability to ... dynamics. , The study, published in today,s issue of ...
(Date:4/14/2014)... Doctors at Henry Ford Hospital reached a medical ... valve replacement using a novel way to access ... hospital in the United States performing the unique ... heart by temporarily connecting major blood vessels. , ... Ford,s first transcaval procedure on July 3, 2013 ...
(Date:4/14/2014)... shows that moderate to severe obstructive sleep apnea is ... and death. , Results of the 20-year follow-up study ... apnea were four times more likely to die (hazard ... have a stroke (HR = 3.7), three times more ... 2.5 times more likely to develop cancer. Results were ...
(Date:4/14/2014)... Popular web information on colorectal cancer is too ... address the appropriate risks to and concerns of patients, ... , In a review of a dozen popular websites, ... cancer screening were written beyond the recommended sixth-grade reading ... key risks, as well as the barriers to and ...
Breaking Medicine News(10 mins):Health News:Changes in processing, handling could reduce commercial fishing injuries 2Health News:Breaking bad mitochondria 2Health News:Henry Ford Hospital hits new heart valve surgery milestone 2Health News:Study links severe sleep apnea to increased risk of stroke, cancer and death 2Health News:Website information on colon cancer too complex, fails to address key concerns 2Health News:Website information on colon cancer too complex, fails to address key concerns 3
... Feb. 25 Omnicell, Inc.,(Nasdaq: OMCL ), a ... today that its Board of Directors has approved the,repurchase ... its Common Stock over,the next 12 months. The Company,s ... after a review of the Company,s financial position and,investment ...
... -- Up to 20 percent of patients taking aspirin ... event do not have an antiplatelet response from aspirin, ... at the University at Buffalo have shown. , ... of a second stroke, second heart attack or second ...
... HILL Bacteria mutate for a living, evading antibiotic drugs ... States each year. But as concern about drug-resistant bacteria grows, ... Carolina at Chapel Hill seeks to thwart the bug without ... Mark Schoenfisch and his lab of analytical chemists at UNC ...
... GmbH, a Systems Biology company focussed on high quality ... showcasing its abilities in the analysis of data generated ... Boyle et al published in the January 2008 issue ... of Open Chromatin across the Genome where they identified ...
... 25 Danaher Corporation,(NYSE: DHR ) announced ... Jr. will be presenting at the Citigroup Global ... March 5 at 8:00,a.m. EST. The audio will ... will be archived on, http://www.danaher.com for one ...
... new blockages within 3 years, study finds , , ... a blood clot in their legs (deep vein thrombosis) ... of developing another blood clot within three years, a ... embolism are known collectively as venous thromboembolism. , Researchers ...
Cached Medicine News:Health News:Omnicell Announces Common Stock Repurchase Program; Reaffirms Earnings Forecast 2Health News:Omnicell Announces Common Stock Repurchase Program; Reaffirms Earnings Forecast 3Health News:Many stroke, heart attack patients may not benefit from aspirin 2Health News:Many stroke, heart attack patients may not benefit from aspirin 3Health News:Silica smart bombs deliver knock-out to bacteria 2Health News:Genomatix integrates genome-wide open chromatin from next generation sequencing 2Health News:Blood Clots in Legs, Lungs Predispose Patients to Repeat Episodes 2
(Date:1/15/2014)... -- Echo Therapeutics, Inc. (Nasdaq: ECTE ) ... CGM System as a non-invasive, wireless continuous glucose ... Doman , Executive Chairman and Interim CEO of ... Capital Markets, Tenth Annual Equity Conference. ... to prospective corporate partners and investors at 9:00 ...
(Date:1/15/2014)... , Jan. 15, 2014 Reportlinker.com ... is available in its catalogue: ... – Worldwide Analysis http://www.reportlinker.com/p01957812/Insulin-Pump-Market--Forecast-–-Worldwide-Analysis.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Equipment_and_Supply ... Analysis Insulin Pumps ... as insulin delivery systems especially for type ...
(Date:1/15/2014)... 2014 Reportlinker.com announces that a ... its catalogue: Global ... Systems -- Focus on End Users ... OBJECTIVES A drug delivery system ... in today,s growth in the pharmaceutical industry. ...
Breaking Medicine Technology:Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3Insulin Pump Market & Forecast - Worldwide Analysis 2Insulin Pump Market & Forecast - Worldwide Analysis 3Insulin Pump Market & Forecast - Worldwide Analysis 4Insulin Pump Market & Forecast - Worldwide Analysis 5Insulin Pump Market & Forecast - Worldwide Analysis 6Insulin Pump Market & Forecast - Worldwide Analysis 7Insulin Pump Market & Forecast - Worldwide Analysis 8Insulin Pump Market & Forecast - Worldwide Analysis 9Insulin Pump Market & Forecast - Worldwide Analysis 10Insulin Pump Market & Forecast - Worldwide Analysis 11Insulin Pump Market & Forecast - Worldwide Analysis 12Insulin Pump Market & Forecast - Worldwide Analysis 13Insulin Pump Market & Forecast - Worldwide Analysis 14Insulin Pump Market & Forecast - Worldwide Analysis 15Insulin Pump Market & Forecast - Worldwide Analysis 16Insulin Pump Market & Forecast - Worldwide Analysis 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 16Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 18
... 2011 Solos Endoscopy, Inc. (OTCPK: SNDY) is pleased to ... switching to Google Apps, will be able to expand and ... help its employees communicate efficiently.  Solos will now have the ... connected computer or mobile device, helping the Company reduce its ...
... Community Pharmacists Association (NCPA) CEO, B. Douglas Hoey, ... the Preserve Community Pharmacy Access NOW! ... culminating an advocacy push that brought community pharmacists to ... Federal Trade Commission (FTC) to reject the proposed mega-merger ...
Cached Medicine Technology:Solos Endoscopy Goes Google 2Solos Endoscopy Goes Google 3Lawmakers, Pharmacists Rally Against Express Scripts-Medco Merger Proposal at U.S. Capitol 2Lawmakers, Pharmacists Rally Against Express Scripts-Medco Merger Proposal at U.S. Capitol 3
Thin and smooth jaws, cross action....
Angled shafts, smooth jaws, polished finish....
... This direct-acting inserter grasps the thinnest ... rim, resulting in a minimum incision requirement. ... around the thicker center of the optic ... optic, resulting in delivery of an implant ...
... This reverseacting inserter allows insertion of second ... as small as 2.8 millimeters, and is ... tunnels. The highly polished rounded blades provide ... providing a slow and controlled release of ...
Medicine Products: