Navigation Links
A thought-provoking new therapeutic target for brain cancer?
Date:2/1/2012

Glioblastoma multiforme (GBM) is the most common of all malignant brain tumors that originate in the brain. Patients with GBM have a poor prognosis because it is a highly aggressive form of cancer that is commonly resistant to current therapies. New therapeutic approaches are therefore much needed. Joanna Phillips, Zena Werb, and colleagues, at the University of California, San Francisco, have now identified a potential new therapeutic target for the treatment of GBM.

A substantial proportion of GBMs show evidence of abnormal activation of signaling pathways triggered by a cell surface protein known as PDGFR-alpha, and this is thought to drive the tumor. PDGFR-alpha triggers activation of signaling pathways when it binds the growth factor PDGF. Phillips, Werb, and colleagues found that the protein SULF2, which is known to regulate the availability of growth factors such as PDGF, was expressed in primary human GBM tumors and cell lines. Moreover, GBMs characterized by abnormal activation of signaling pathways downstream of PDGFR-alpha showed the strongest SULF2 expression. Importantly, knocking down expression of SULF2 in human GBM cell lines decreased the growth of these cells upon transplantation into mice. Phillips, Werb, and colleagues therefore suggest that SULF2 is a candidate therapeutic target for the treatment of GBM and that assessing its levels could identify tumors dependent on growth factors such as PDGF. The latter is important as PDGFR-alpha and other molecules to which growth factors bind are themselves good therapeutic targets.


'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. New therapeutic target to combat liver cancer discovered
2. Researchers identify a novel therapeutic approach for liver cancer
3. BRAF addiction of thyroid cancers makes them therapeutically vulnerable
4. Researchers help in search for new ways to image, therapeutically target melanoma
5. Wayne State therapeutic marijuana use study could impact state policies, guide treatment
6. Novel therapeutic target identified to decrease triglycerides and increase good cholesterol
7. Mayo Clinic study guides physicians using therapeutic cooling to treat cardiac arrest patients
8. NIH funds development of new broad-spectrum therapeutics
9. New potential therapeutic target for breast cancer
10. AACR hosts molecular targets and cancer therapeutics conference
11. OGI and MaRS Innovation invest in peptide therapeutics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... March 24, 2017 , ... The iaedp Foundation, the ... medical professionals caring for those suffering from the full spectrum of disordered eating, announced ... eating disorders professionals from nearly all 50 states and several countries converged on the ...
(Date:3/24/2017)... ... 2017 , ... Shamanic healer and teacher Anahata Ananda of ... Awakening, proudly presents her Sacred Peru retreat with world famous shaman and ... during the Summer Solstice will also be her final international retreat, Anahata announced ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... wanted to create a communications platform that positions them as the go-to thought ... ONS reinvented their online publication as an always-on, always-fresh news, views and advocacy ...
(Date:3/24/2017)... ... March 24, 2017 , ... On June 9, 2017, ... Claims Litigation seminar in Chicago, Illinois. She will present on: , Filing ... litigated under ERISA involve claims for long-term disability benefits. This session will ...
(Date:3/24/2017)... ... ... Viewers who like to educate themselves on current issues and who enjoy gaining knowledge ... tend to appreciate and love the "Informed" series, hosted by Rob Lowe. A ... around the world. , Running for charity has become a multi-million dollar ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... -- Research and Markets has announced the addition of the ... offering. ... the worldwide markets for Dental Implants in US$ Million. The report provides ... Japan , Europe , Asia-Pacific ... Annual estimates and forecasts are provided for the period ...
(Date:3/24/2017)... FinancialBuzz.com News Commentary   ... Medical cannabis products around the world are projected to gain popularity. ... cannabis market will reach a value of USD 55.8 billion by 2025. ... new growing industry. By the end of 2016, 28 states have now ... More conservative states like Arkansas and ...
(Date:3/24/2017)... 2017 Global Ampoules Market report ... classifications, applications and industry chain structure. The Ampoules market ... history, competitive landscape analysis, and major regions, development status. ... ... pages providing 10 company profiles and 183 tables and ...
Breaking Medicine Technology: