Navigation Links
A taxing issue: How human T-lymphotropic virus
Date:1/30/2008

Researchers have identified a potential new mechanism through which human T-lymphotropic virus type-1 (HTLV-1) causes leukemia in adults. The findings, published this week in the online open access journal Retrovirology, represent the first time that a reduction in histone protein levels has been linked to viral infection and the development of cancer.

HTLV-1 is a retrovirus that causes adult T-cell leukaemia/lymphoma (ATLL). A single protein made by the virus, Tax, is thought to be enough to trigger cancer development. Tax has a number of effects in the cell, including promoting inappropriate cell division, repressing DNA repair mechanisms and causing genomic instability. These effects are thought to combine and cause cancer, although the exact details of the process are unclear.

James Bogenberger and Paul Laybourn from Colorado State University, USA found that the levels of histone proteins and histone transcripts were lower in T-cell lines infected with HTLV-1 than in uninfected cell lines. They also showed that Tax could cause a drop in the levels of histone transcript in uninfected cells.

Histone proteins are required for the packaging of DNA in cell nuclei and are involved in many key processes associated with DNA, including transcription, repair and replication. The authors suggest that Tax uncouples cell division and replication-dependent histone gene expression, allowing cell division to continue while the levels of histone protein fall.

They write: We suggest Tax repression of replication-dependent histone gene expression will result in reactivation of viral gene expression, deregulation of cellular gene expression and genomic instability. All of these effects may contribute to the development of adult T-cell leukemia/lymphoma. To our knowledge, this is the first example of a reduction of histone levels correlating with viral infection and cancer development.


'/>"/>

Contact: Charlotte Webber
press@biomedcentral.com
44-020-763-19980
BioMed Central
Source:Eurekalert

Page: 1

Related medicine news :

1. Study finds genetic link to human herpes susceptibility
2. Common human viruses threaten endangered great apes
3. Humanities Texas Announces Winners of The First Humanities Texas Award
4. Evolutionary phenomenon in mice may explain human infertility
5. Can hantavirus infection spread among humans?
6. Unique Gift for Valentines Day: Canine Cancer Campaign Customized Dog Tag - for Your Dog or as a Beautiful Piece of Jewelry for a Special Human
7. Bankers Life and Casualty Company Joins LifePlans, Inc. and the Department of Health and Human Services to Launch Fall Prevention Program Study For Americas Seniors
8. Contact lenses with circuits, lights a possible platform for superhuman vision
9. Wachovia Foundation Announces $1 Million Each for Atlanta BeltLine Partnership, Center for Civil and Human Rights
10. Evolution of human genomes guardian gives people unique protections from DNA damage
11. A new significance of LVD and angiogenic MVD is identified in human primary SCRC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/26/2017)... Barcelona, Spain (PRWEB) , ... September 26, 2017 ... ... exciting nutritional ingredient that is not only entirely new and different, it is ... extracts, announced today that the company has received an exclusive license agreement with ...
(Date:9/26/2017)... ... September 26, 2017 , ... Data Integrity: , The ... **, Dec. 5-6, 2017 – Arlington, VA, http://www.fdanews.com/fdadataintegrity , ... indicate the firm’s electronic records may not be trustworthy and reliable … a more ...
(Date:9/26/2017)... ... September 26, 2017 , ... The 2017 American Academy ... “The Magic of Fat,” revealed not only the latest about cosmetic procedures to remove ... an evolution in cosmetic medicine. , “Fat really is magical, especially when it comes ...
(Date:9/26/2017)... ... ... “Good Morning Sunshine!: Finding Strength and Comfort in God”: a hopeful and ... Comfort in God” is the creation of published author, Terri Braun, a mother of ... at a local mental health center for over twenty years, helping the severely and ...
(Date:9/26/2017)... ... September 26, 2017 , ... “Sonflower Submission”: a relatable and concise reality ... destinations of negativity, complaining and the need to always be correct. There comes a ... for a lesson in stress-less living to be learned. “Sonflower Submission” is the ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... PROVIDENCE, R.I. , Sept. 25, 2017 /PRNewswire/ ... immunogenicity assessment, vaccine design, and immune-engineering today announced ... focused on the development of personalized therapeutic cancer ... and has provided exclusive access to enabling technologies ... MSc Eng., MBA will lead EpiVax Oncology as ...
(Date:9/22/2017)... Md. , Sept. 22, 2017  As the ... Republican Senators Bill Cassidy (R-LA) and ... Information notes that the medical device industry is in ... medical device tax, the 2.3% excise tax on medical ... But they also want covered patients, increased visits and ...
(Date:9/19/2017)... Inc., a venture-backed medical device company developing a non-invasive, robotically assisted, platform therapy that uses ... today:   ... Jim ... Tom Tefft ... Veteran medical device executive Josh Stopek , PhD, who has led R&D and business ...
Breaking Medicine Technology: