Navigation Links
A taxing issue: How human T-lymphotropic virus
Date:1/30/2008

Researchers have identified a potential new mechanism through which human T-lymphotropic virus type-1 (HTLV-1) causes leukemia in adults. The findings, published this week in the online open access journal Retrovirology, represent the first time that a reduction in histone protein levels has been linked to viral infection and the development of cancer.

HTLV-1 is a retrovirus that causes adult T-cell leukaemia/lymphoma (ATLL). A single protein made by the virus, Tax, is thought to be enough to trigger cancer development. Tax has a number of effects in the cell, including promoting inappropriate cell division, repressing DNA repair mechanisms and causing genomic instability. These effects are thought to combine and cause cancer, although the exact details of the process are unclear.

James Bogenberger and Paul Laybourn from Colorado State University, USA found that the levels of histone proteins and histone transcripts were lower in T-cell lines infected with HTLV-1 than in uninfected cell lines. They also showed that Tax could cause a drop in the levels of histone transcript in uninfected cells.

Histone proteins are required for the packaging of DNA in cell nuclei and are involved in many key processes associated with DNA, including transcription, repair and replication. The authors suggest that Tax uncouples cell division and replication-dependent histone gene expression, allowing cell division to continue while the levels of histone protein fall.

They write: We suggest Tax repression of replication-dependent histone gene expression will result in reactivation of viral gene expression, deregulation of cellular gene expression and genomic instability. All of these effects may contribute to the development of adult T-cell leukemia/lymphoma. To our knowledge, this is the first example of a reduction of histone levels correlating with viral infection and cancer development.


'/>"/>

Contact: Charlotte Webber
press@biomedcentral.com
44-020-763-19980
BioMed Central
Source:Eurekalert

Page: 1

Related medicine news :

1. Study finds genetic link to human herpes susceptibility
2. Common human viruses threaten endangered great apes
3. Humanities Texas Announces Winners of The First Humanities Texas Award
4. Evolutionary phenomenon in mice may explain human infertility
5. Can hantavirus infection spread among humans?
6. Unique Gift for Valentines Day: Canine Cancer Campaign Customized Dog Tag - for Your Dog or as a Beautiful Piece of Jewelry for a Special Human
7. Bankers Life and Casualty Company Joins LifePlans, Inc. and the Department of Health and Human Services to Launch Fall Prevention Program Study For Americas Seniors
8. Contact lenses with circuits, lights a possible platform for superhuman vision
9. Wachovia Foundation Announces $1 Million Each for Atlanta BeltLine Partnership, Center for Civil and Human Rights
10. Evolution of human genomes guardian gives people unique protections from DNA damage
11. A new significance of LVD and angiogenic MVD is identified in human primary SCRC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2017)... Indianapolis, IN (PRWEB) , ... April 25, 2017 ... ... Washington, D.C., CEOs, CFOs and HR decision-makers are preparing for how his administration ... Life Financial will provide insight into what changes are most likely to make ...
(Date:4/25/2017)... ... April 25, 2017 , ... Patients ... that achieves results in a fraction of the time as traditional braces – ... Significance Dental Specialists, now offers this revolutionary treatment with or without a referral. ...
(Date:4/25/2017)... ... 2017 , ... Buyers and sellers in the thriving multi-billion dollar cannabis marketplace ... help but be heartened by the industry’s current surge. But another thing that unifies ... smell.” At last they can simply, safely and effectively end their aroma anguish ...
(Date:4/25/2017)... ... , ... There is no better place in South Florida to undergo two ... May issue of Consumer Reports focused on heart health. , The magazine gave ... after coronary bypass and aortic valve replacement procedures. , Consumer Reports rated ...
(Date:4/24/2017)... ORLANDO, FLORIDA (PRWEB) , ... April 24, 2017 ... ... of telehealth technology yesterday, featuring Bring Your Own Device (BYOD) capabilities at Telehealth ... compliment LG CNS’ pre-packaged telehealth bundles, which pairs medical devices with a pre-programmed ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... 19, 2017  New research provides evidence that an old ... to a study released today that will be presented at ... in Boston , April 22 to 28, ... of Parkinson,s disease, the oral drug levodopa has long been ... But as the disease progresses, the effects of the medication ...
(Date:4/19/2017)... , April 19, 2017  SARES•REGIS Group leased ... is developing at Conejo Spectrum Business Park in ... Atara Biotherapeutics, Inc. , a biopharmaceutical company ... life-threatening diseases that have been underserved by scientific ... therapies for cancer, autoimmune and infectious disease. ...
(Date:4/18/2017)... , April 18, 2017 Cogentix Medical, ... on providing the Urology, Uro/Gyn and Gynecology markets with ... the first quarter ended March 31, 2017 after the ... The Company will host a conference call and ... on Tuesday, May 2, 2017 at 4:30 p.m. Eastern ...
Breaking Medicine Technology: