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A surprise 'spark' for pre-cancerous colon polyps
Date:5/14/2009

e. Before the new study, scientists believed that following APC mutation, faulty cell communication caused by a particular protein known as beta-catenin resulted in colon polyp formation. Colon polyp formation precedes the development of colon cancer.

While considerable evidence implicates dysregulated Wnt/beta-catenin signaling as the initiating event underlying colon adenoma formation following loss of APC, several studies examining human FAP adenomas raised the possibility that APC loss alone is insufficient to promote aberrant Wnt/beta-catenin signaling. These findings suggest that beta-catenin dependent intestinal cell proliferation may contribute to adenoma progression, rather than initiation following loss of APC.

According to the National Cancer Institute, there are about 108,070 new cases of colon cancer and 40,740 new cases of rectal cancer each year in the United States. Colon and rectal cancers together claim 49,960 lives in the country annually.


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Contact: Linda Aagard
linda.aagard@hci.utah.edu
801-587-7639
University of Utah
Source:Eurekalert

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