Navigation Links
A surprise 'spark' for pre-cancerous colon polyps
Date:5/14/2009

SALT LAKE CITY Researchers at Huntsman Cancer Institute (HCI) at the University of Utah studied the events leading to colon cancer and found that an unexpected protein serves as the "spark" that triggers formation of colon polyps, the precursors to cancerous tumors.

"Our findings will certainly raise some eyebrows," says oncological sciences graduate student Reid Phelps, first author of the study, which will be published Friday, May 15 in the journal Cell. "We expect the conventional wisdom regarding colon tumor development to be reconsidered, together with some resistance to our alternative explanation."

The study in zebrafish and human cells discovered that a protein, known as C-terminal binding protein 1, or CTBP1, was the spark that initiated colon polyp formation, not the protein beta-catenin, as previously thought. With this new information, future treatments that prevent tumor progression can be developed.

The research centered on the mutation of a tumor-suppressor gene called APC a mutation previously found to be present in 85 percent of all colon cancers. Since then, research labs around the world have developed theories about how the gene works in colon cancer development.

"Our work reveals new information about how the APC protein functions to prevent colon tumor formation. This new information opens new possibilities treating and preventing colon cancer. " says David Jones, Ph.D., a professor of oncological sciences at the University of Utah and senior director of early translational research at HCI. "We want to know what happens immediately following mutation of the APC gene mutation as a way of understanding how we might intervene. If you're trying to match therapies with a specific genetic mutation, it helps to understand the earliest steps in tumor formation, as well as the downstream consequences."

APC stands for adenomatous polyposis coli. It is classified as a tumor suppressor gene. Before the new study, scientists believed that following APC mutation, faulty cell communication caused by a particular protein known as beta-catenin resulted in colon polyp formation. Colon polyp formation precedes the development of colon cancer.

While considerable evidence implicates dysregulated Wnt/beta-catenin signaling as the initiating event underlying colon adenoma formation following loss of APC, several studies examining human FAP adenomas raised the possibility that APC loss alone is insufficient to promote aberrant Wnt/beta-catenin signaling. These findings suggest that beta-catenin dependent intestinal cell proliferation may contribute to adenoma progression, rather than initiation following loss of APC.

According to the National Cancer Institute, there are about 108,070 new cases of colon cancer and 40,740 new cases of rectal cancer each year in the United States. Colon and rectal cancers together claim 49,960 lives in the country annually.


'/>"/>

Contact: Linda Aagard
linda.aagard@hci.utah.edu
801-587-7639
University of Utah
Source:Eurekalert

Related medicine news :

1. Sweet Surprise: Even Former Critics Dispel Long-Held Myths About High Fructose Corn Syrup
2. Surprise discovery made in cancer research
3. Blue Cross/Blue Shield Christmas Gift to Federal Employees: Surprise, Were Cutting Your Benefits!; Patients, Doctors and Health Care Providers Outraged
4. Hey fever! The surprise benefit of allergies
5. NARALS CHOICE: Is Anyone Surprised About Out-of-the-Mainstream NARALs Choice of Barack Obama for President?
6. This Mothers Day, Surprise Mom With a New Way to Give
7. Easter Eggs May Hold Some Unwanted Surprises
8. Surprise Orgasms Baffle Women Undergoing New Infertility Treatment
9. Surprise U.S. Supreme Court Decision Helps Michigan Citizens
10. Surprise in Lab Helps ID Drug to Fight ALS
11. Swine Flu Pandemic Sparks Travel Insurance Panic Buying, Says Confused.com
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids ... sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited ... all ages; it is a non-competitive, non-timed event, which is all about having fun ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and the ... published author, William Nowers. Captain Nowers and his wife, Millie, have six children, ... in the Navy. Following his career as a naval aviator and carrier pilot, ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), ... of an innovative new design of the shoulder pad. The shoulder pad provides ... while controlling your pain while using cold therapy. By utilizing ice and water that ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... HMP ... the recipient of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare ... City on October 11, 2017. , The annual award competition recognizes editorial and design ...
(Date:10/12/2017)... BALTIMORE (PRWEB) , ... October 12, 2017 , ... ... average of $3,296 in property taxes a year. In some states—like New York, ... higher. , By contrast, many overseas retirement havens have extremely low property-tax rates, ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017 Diplomat Pharmacy, ... 8th Day Software and Consulting, LLC , and named ... 8th Day Software, based in Tennessee , ... 8th Day expands EnvoyHealth,s service offerings for health care ... "In an interoperable ...
(Date:9/28/2017)... 2017 Hill-Rom Holdings, Inc. (NYSE: HRC), will ... and webcast on Friday, November 3, 2017, beginning at ... at approximately 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... financial performance and guidance for 2018, Hill-Rom executives will ... operational performance, and long-range financial outlook through 2020. ...
(Date:9/25/2017)... 2017  EpiVax, Inc., a leader in the ... today announced the launch of EpiVax Oncology Inc., ... therapeutic cancer vaccines. EpiVax has provided $500,000 in ... enabling technologies to the new precision immunotherapy venture. ... Oncology as Chief Executive Officer. Gad brings over ...
Breaking Medicine Technology: