Navigation Links
A surprise 'spark' for pre-cancerous colon polyps
Date:5/14/2009

SALT LAKE CITY Researchers at Huntsman Cancer Institute (HCI) at the University of Utah studied the events leading to colon cancer and found that an unexpected protein serves as the "spark" that triggers formation of colon polyps, the precursors to cancerous tumors.

"Our findings will certainly raise some eyebrows," says oncological sciences graduate student Reid Phelps, first author of the study, which will be published Friday, May 15 in the journal Cell. "We expect the conventional wisdom regarding colon tumor development to be reconsidered, together with some resistance to our alternative explanation."

The study in zebrafish and human cells discovered that a protein, known as C-terminal binding protein 1, or CTBP1, was the spark that initiated colon polyp formation, not the protein beta-catenin, as previously thought. With this new information, future treatments that prevent tumor progression can be developed.

The research centered on the mutation of a tumor-suppressor gene called APC a mutation previously found to be present in 85 percent of all colon cancers. Since then, research labs around the world have developed theories about how the gene works in colon cancer development.

"Our work reveals new information about how the APC protein functions to prevent colon tumor formation. This new information opens new possibilities treating and preventing colon cancer. " says David Jones, Ph.D., a professor of oncological sciences at the University of Utah and senior director of early translational research at HCI. "We want to know what happens immediately following mutation of the APC gene mutation as a way of understanding how we might intervene. If you're trying to match therapies with a specific genetic mutation, it helps to understand the earliest steps in tumor formation, as well as the downstream consequences."

APC stands for adenomatous polyposis coli. It is classified as a tumor suppressor gene. Before the new study, scientists believed that following APC mutation, faulty cell communication caused by a particular protein known as beta-catenin resulted in colon polyp formation. Colon polyp formation precedes the development of colon cancer.

While considerable evidence implicates dysregulated Wnt/beta-catenin signaling as the initiating event underlying colon adenoma formation following loss of APC, several studies examining human FAP adenomas raised the possibility that APC loss alone is insufficient to promote aberrant Wnt/beta-catenin signaling. These findings suggest that beta-catenin dependent intestinal cell proliferation may contribute to adenoma progression, rather than initiation following loss of APC.

According to the National Cancer Institute, there are about 108,070 new cases of colon cancer and 40,740 new cases of rectal cancer each year in the United States. Colon and rectal cancers together claim 49,960 lives in the country annually.


'/>"/>

Contact: Linda Aagard
linda.aagard@hci.utah.edu
801-587-7639
University of Utah
Source:Eurekalert

Related medicine news :

1. Sweet Surprise: Even Former Critics Dispel Long-Held Myths About High Fructose Corn Syrup
2. Surprise discovery made in cancer research
3. Blue Cross/Blue Shield Christmas Gift to Federal Employees: Surprise, Were Cutting Your Benefits!; Patients, Doctors and Health Care Providers Outraged
4. Hey fever! The surprise benefit of allergies
5. NARALS CHOICE: Is Anyone Surprised About Out-of-the-Mainstream NARALs Choice of Barack Obama for President?
6. This Mothers Day, Surprise Mom With a New Way to Give
7. Easter Eggs May Hold Some Unwanted Surprises
8. Surprise Orgasms Baffle Women Undergoing New Infertility Treatment
9. Surprise U.S. Supreme Court Decision Helps Michigan Citizens
10. Surprise in Lab Helps ID Drug to Fight ALS
11. Swine Flu Pandemic Sparks Travel Insurance Panic Buying, Says Confused.com
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... ... February 24, 2017 , ... Only two months after ... Travel Market (ILTM) show in Cannes (France), XO Private has initiated a second print-run ... 420-page book measures almost a metre across when open, weighs in at more than ...
(Date:2/24/2017)... , ... February 24, 2017 , ... An in-depth computational ... the University of Pittsburgh points to eight genes that may explain why susceptibility to ... to the results of a study published today in the journal npj Schizophrenia. ...
(Date:2/24/2017)... ... 2017 , ... The Smart Machine Age is here, and it’s disrupting everything. ... of all jobs in the United States may be taken over by technology in ... aggressive know-it-all who steamrolls over colleagues is drawing to a close. Success will belong ...
(Date:2/24/2017)... ... 2017 , ... With millions of Americans and people worldwide ... all are aware of our options and are empowered with strength and information ... of its newest edition of "Vision and Hearing" in USA Today, that will ...
(Date:2/24/2017)... ... February 24, 2017 , ... The narrative in “ Signal 8: An Australian ... account of his paramedic experiences. Schanssema describes the tragedies he saw, as well as ... overcome them. , Schanssema, initially unsure of the career path he wanted to take, ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... 2017 Zimmer Biomet Holdings, Inc. (NYSE and ... present at the Cowen and Company 37 th ... Place on Tuesday, March 7, 2017 at 11:20 a.m. ... the presentation can be accessed at http://wsw.com/webcast/cowen38/zbh .  ... conference via Zimmer Biomet,s Investor Relations website at ...
(Date:2/24/2017)... , Feb. 24, 2017  In conjunction with ... 2016 financial results press release, you are invited to ... live over the internet on Tuesday, March 14, 2017 ... A live audio webcast of the presentation ... www.durect.com and clicking "Investor Relations."  If you are ...
(Date:2/24/2017)... ITL Limited, ( ASX: ITD ), ... für das zum 31. Dezember 2016 endende Halbjahr ... vorlegen zu können. Eine vollständige Präsentation „Ergebnisse von ... Sie hier . Glanzpunkte ... 2015: 1,04 Millionen USD; +104 %) Gewinn je ...
Breaking Medicine Technology: